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    Myom1 myomesin 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 316740, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Myom1provided by RGD
    Official Full Name
    myomesin 1provided by RGD
    Primary source
    RGD:631436
    See related
    EnsemblRapid:ENSRNOG00000057701 AllianceGenome:RGD:631436
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable kinase binding activity and protein homodimerization activity. Involved in extraocular skeletal muscle development. Located in M band. Orthologous to human MYOM1 (myomesin 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Muscle (RPKM 1896.5) and Heart (RPKM 1389.6) See more
    Orthologs
    human mouse all
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    Genomic context

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    See Myom1 in Genome Data Viewer
    Location:
    9q38
    Exon count:
    39
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (118362547..118485954)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (110916156..111039344)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (119353840..119469196)

    Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene myosin light chain 12B Neighboring gene uncharacterized LOC102555687 Neighboring gene myosin light chain 12A Neighboring gene uncharacterized LOC102555849 Neighboring gene U6 spliceosomal RNA

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Superhelical architecture of the myosin filament-linking protein myomesin with unusual elastic properties. Pinotsis N, et al. PLoS Biol, 2012 Feb. PMID 22347812, Free PMC Article
    2. Molecular basis of the C-terminal tail-to-tail assembly of the sarcomeric filament protein myomesin. Pinotsis N, et al. EMBO J, 2008 Jan 9. PMID 18059477, Free PMC Article
    3. Nuclear localization of Myomesin-1: possible functions. Reddy KB, et al. J Muscle Res Cell Motil, 2008. PMID 18521710
    4. Postnatal suppression of myomesin, muscle creatine kinase and the M-line in rat extraocular muscle. Porter JD, et al. J Exp Biol, 2003 Sep. PMID 12878677
    5. Sarcosin (Krp1) in skeletal muscle differentiation: gene expression profiling and knockdown experiments. du Puy L, et al. Int J Dev Biol, 2012. PMID 22562206

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables kinase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables kinase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in extraocular skeletal muscle development IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in positive regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of protein secretion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein kinase A signaling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in sarcomere organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in M band IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in M band IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in M band ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in sarcomere ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    myomesin-1
    Names
    myomesin 1 (skelemin) 185kDa

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001191584.2 → NP_001178513.1  myomesin-1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000009
      UniProtKB/TrEMBL
      A0A0G2K5P5, A0A8I6GBP8
      Conserved Domains (4) summary
      cd00063
      Location:641 → 734
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00096
      Location:1576 → 1579
      Ig; Ig strand A [structural motif]
      cd20951
      Location:281 → 374
      IgI_titin_I1-like; Immunoglobulin domain I1 of the titin I-band and similar proteins; a member of the I-set of IgSF domains
      cl11960
      Location:1576 → 1667
      Ig; Immunoglobulin domain

    2. NM_001432105.1 → NP_001419034.1  myomesin-1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000009
      UniProtKB/TrEMBL
      A0A0G2K5P5, A0A8I6GFM8

    3. NM_001432106.1 → NP_001419035.1  myomesin-1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000009
      UniProtKB/TrEMBL
      A0A0G2K5P5, A0A8I6GFM8

    4. NM_001432107.1 → NP_001419036.1  myomesin-1 isoform 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000009
      UniProtKB/TrEMBL
      A0A0G2K5P5

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086027.1 Reference GRCr8

      Range
      118362547..118485954
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039083797.2 → XP_038939725.1  myomesin-1 isoform X1

      Related
      ENSRNOP00000101346.1, ENSRNOT00000173417.1
      Conserved Domains (4) summary
      cd00063
      Location:641 → 734
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00096
      Location:1479 → 1482
      Ig; Ig strand A [structural motif]
      cd20951
      Location:281 → 374
      IgI_titin_I1-like; Immunoglobulin domain I1 of the titin I-band and similar proteins; a member of the I-set of IgSF domains
      cl11960
      Location:1479 → 1570
      Ig; Immunoglobulin domain

    2. XM_039083799.2 → XP_038939727.1  myomesin-1 isoform X2

      Related
      ENSRNOP00000085118.1, ENSRNOT00000112958.2
      Conserved Domains (4) summary
      cd00063
      Location:641 → 734
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00096
      Location:1576 → 1579
      Ig; Ig strand A [structural motif]
      cd20951
      Location:281 → 374
      IgI_titin_I1-like; Immunoglobulin domain I1 of the titin I-band and similar proteins; a member of the I-set of IgSF domains
      cl11960
      Location:1576 → 1667
      Ig; Immunoglobulin domain

    3. XM_039083798.2 → XP_038939726.1  myomesin-1 isoform X1

      Conserved Domains (4) summary
      cd00063
      Location:641 → 734
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00096
      Location:1479 → 1482
      Ig; Ig strand A [structural motif]
      cd20951
      Location:281 → 374
      IgI_titin_I1-like; Immunoglobulin domain I1 of the titin I-band and similar proteins; a member of the I-set of IgSF domains
      cl11960
      Location:1479 → 1570
      Ig; Immunoglobulin domain
    Nucleotide Protein Strain
    Heading Accession and Version

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