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    Aasdh aminoadipate-semialdehyde dehydrogenase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 364136, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Aasdhprovided by RGD
    Official Full Name
    aminoadipate-semialdehyde dehydrogenaseprovided by RGD
    Primary source
    RGD:1311135
    See related
    EnsemblRapid:ENSRNOG00000002137 AllianceGenome:RGD:1311135
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1311135
    Summary
    Predicted to enable nucleotide binding activity. Predicted to be involved in amino acid activation for nonribosomal peptide biosynthetic process. Predicted to act upstream of or within beta-alanine metabolic process. Orthologous to human AASDH (aminoadipate-semialdehyde dehydrogenase). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 54.7), Spleen (RPKM 50.4) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Aasdh in Genome Data Viewer
    Location:
    14p11
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (31609488..31636066)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (31255019..31281802)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (33619990..33647268)

    Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120096737 Neighboring gene signal recognition particle 72 Neighboring gene phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthase Neighboring gene phosphoribosyl pyrophosphate amidotransferase Neighboring gene uncharacterized LOC120096736 Neighboring gene capping protein inhibiting regulator of actin dynamics Neighboring gene ribosomal protein L23a, pseudogene 19

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Vertebrate Acyl CoA synthetase family member 4 (ACSF4-U26) is a β-alanine-activating enzyme homologous to bacterial non-ribosomal peptide synthetase. Drozak J, et al. FEBS J, 2014 Mar. PMID 24467666
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in amino acid activation for nonribosomal peptide biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within amino acid activation for nonribosomal peptide biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within beta-alanine metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    beta-alanine-activating enzyme
    Names
    acyl-CoA synthetase family member 4
    NP_001385951.1
    XP_038948856.1
    XP_038948857.1
    XP_038948859.1
    XP_038948861.1
    XP_038948862.1
    XP_038948863.1
    XP_038948864.1
    XP_063129488.1
    XP_063129489.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001399022.1 → NP_001385951.1  beta-alanine-activating enzyme

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000014
      UniProtKB/TrEMBL
      D4A5F5
      Conserved Domains (4) summary
      COG1520
      Location:753 → 1048
      PQQ; Outer membrane protein assembly factor BamB, contains PQQ-like beta-propeller repeat [Cell wall/membrane/envelope biogenesis]
      sd00039
      Location:751 → 786
      7WD40; WD40 repeat [structural motif]
      cd17654
      Location:16 → 532
      A_NRPS_acs4; acyl-CoA synthetase family member 4
      pfam13570
      Location:1059 → 1091
      PQQ_3; PQQ-like domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086032.1 Reference GRCr8

      Range
      31609488..31636066
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039092935.2 → XP_038948863.1  beta-alanine-activating enzyme isoform X4

      Conserved Domains (3) summary
      sd00039
      Location:751 → 786
      7WD40; WD40 repeat [structural motif]
      cd17654
      Location:16 → 532
      A_NRPS_acs4; acyl-CoA synthetase family member 4
      pfam13360
      Location:791 → 971
      PQQ_2; PQQ-like domain

    2. XM_039092928.2 → XP_038948856.1  beta-alanine-activating enzyme isoform X1

      UniProtKB/TrEMBL
      D4A5F5
      Related
      ENSRNOP00000002907.5, ENSRNOT00000002907.7
      Conserved Domains (4) summary
      COG1520
      Location:753 → 1048
      PQQ; Outer membrane protein assembly factor BamB, contains PQQ-like beta-propeller repeat [Cell wall/membrane/envelope biogenesis]
      sd00039
      Location:751 → 786
      7WD40; WD40 repeat [structural motif]
      cd17654
      Location:16 → 532
      A_NRPS_acs4; acyl-CoA synthetase family member 4
      pfam13570
      Location:1059 → 1091
      PQQ_3; PQQ-like domain

    3. XM_039092934.2 → XP_038948862.1  beta-alanine-activating enzyme isoform X3

      Conserved Domains (3) summary
      sd00039
      Location:751 → 786
      7WD40; WD40 repeat [structural motif]
      cd17654
      Location:16 → 532
      A_NRPS_acs4; acyl-CoA synthetase family member 4
      pfam13360
      Location:791 → 973
      PQQ_2; PQQ-like domain

    4. XM_039092933.2 → XP_038948861.1  beta-alanine-activating enzyme isoform X2

      Related
      ENSRNOP00000108559.1, ENSRNOT00000144479.1
      Conserved Domains (4) summary
      COG1520
      Location:753 → 1029
      PQQ; Outer membrane protein assembly factor BamB, contains PQQ-like beta-propeller repeat [Cell wall/membrane/envelope biogenesis]
      sd00039
      Location:751 → 786
      7WD40; WD40 repeat [structural motif]
      cd17654
      Location:16 → 532
      A_NRPS_acs4; acyl-CoA synthetase family member 4
      pfam13570
      Location:1015 → 1047
      PQQ_3; PQQ-like domain

    5. XM_039092936.2 → XP_038948864.1  beta-alanine-activating enzyme isoform X5

      Conserved Domains (3) summary
      COG1520
      Location:553 → 793
      PQQ; Outer membrane protein assembly factor BamB, contains PQQ-like beta-propeller repeat [Cell wall/membrane/envelope biogenesis]
      cd17654
      Location:16 → 528
      A_NRPS_acs4; acyl-CoA synthetase family member 4
      pfam01011
      Location:525 → 555
      PQQ; PQQ enzyme repeat

    6. XM_039092931.2 → XP_038948859.1  beta-alanine-activating enzyme isoform X1

      UniProtKB/TrEMBL
      D4A5F5
      Conserved Domains (4) summary
      COG1520
      Location:753 → 1048
      PQQ; Outer membrane protein assembly factor BamB, contains PQQ-like beta-propeller repeat [Cell wall/membrane/envelope biogenesis]
      sd00039
      Location:751 → 786
      7WD40; WD40 repeat [structural motif]
      cd17654
      Location:16 → 532
      A_NRPS_acs4; acyl-CoA synthetase family member 4
      pfam13570
      Location:1059 → 1091
      PQQ_3; PQQ-like domain

    7. XM_039092929.1 → XP_038948857.1  beta-alanine-activating enzyme isoform X1

      UniProtKB/TrEMBL
      D4A5F5
      Conserved Domains (4) summary
      COG1520
      Location:753 → 1048
      PQQ; Outer membrane protein assembly factor BamB, contains PQQ-like beta-propeller repeat [Cell wall/membrane/envelope biogenesis]
      sd00039
      Location:751 → 786
      7WD40; WD40 repeat [structural motif]
      cd17654
      Location:16 → 532
      A_NRPS_acs4; acyl-CoA synthetase family member 4
      pfam13570
      Location:1059 → 1091
      PQQ_3; PQQ-like domain

    8. XM_063273419.1 → XP_063129489.1  beta-alanine-activating enzyme isoform X6

      UniProtKB/TrEMBL
      A6JCX1

    9. XM_063273418.1 → XP_063129488.1  beta-alanine-activating enzyme isoform X6

      UniProtKB/TrEMBL
      A6JCX1
    Nucleotide Protein Strain
    Heading Accession and Version

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