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    Fam98c family with sequence similarity 98, member C [ Rattus norvegicus (Norway rat) ]

    Gene ID: 292764, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Fam98cprovided by RGD
    Official Full Name
    family with sequence similarity 98, member Cprovided by RGD
    Primary source
    RGD:1303117
    See related
    EnsemblRapid:ENSRNOG00000024036 AllianceGenome:RGD:1303117
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1303117
    Summary
    Predicted to be part of tRNA-splicing ligase complex. Orthologous to human FAM98C (family with sequence similarity 98 member C). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 74.2), Spleen (RPKM 63.3) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Fam98c in Genome Data Viewer
    Location:
    1q21
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (93580286..93583894, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (84452806..84456414, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (88095240..88098828, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene MARCKS-related protein-like Neighboring gene mitogen activated protein kinase kinase kinase kinase 1 Neighboring gene ryanodine receptor 1 Neighboring gene RAS guanyl releasing protein 4 Neighboring gene sprouty-related, EVH1 domain containing 3 Neighboring gene gametogenetin

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Gene expression profile of the rat eye iridocorneal angle: NEIBank expressed sequence tag analysis. Ahmed F, et al. Invest Ophthalmol Vis Sci, 2004 Sep. PMID 15326124
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC94040

    Gene Ontology Provided by RGD

    Component Evidence Code Pubs
    part_of tRNA-splicing ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    protein FAM98C

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001198584.1 → NP_001185513.1  protein FAM98C

      See identical proteins and their annotated locations for NP_001185513.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes a 344aa protein.
      Source sequence(s)
      BC079080, CO564588, CO570848
      UniProtKB/TrEMBL
      F1LQ27
      Related
      ENSRNOP00000053799.4, ENSRNOT00000056964.5
      Conserved Domains (1) summary
      pfam10239
      Location:10 → 325
      DUF2465; Protein of unknown function (DUF2465)

    RNA

    1. NR_037147.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) has an additional segment in the 5' region, as compared to variant 1. The transcript is a nonsense-mediated mRNA decay candidate and probably does not make a protein.
      Source sequence(s)
      BC079080, CO570848

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      93580286..93583894 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006228717.4 → XP_006228779.1  protein FAM98C isoform X1

      See identical proteins and their annotated locations for XP_006228779.1

      UniProtKB/TrEMBL
      F1LQ27
      Conserved Domains (1) summary
      pfam10239
      Location:10 → 325
      DUF2465; Protein of unknown function (DUF2465)

    2. XM_063283452.1 → XP_063139522.1  protein FAM98C isoform X3

    3. XM_063283450.1 → XP_063139520.1  protein FAM98C isoform X2

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001004219.1: Suppressed sequence

      Description
      NM_001004219.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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