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    Cdc45 cell division cycle 45 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 287961, updated on 27-Dec-2024

    Summary

    Official Symbol
    Cdc45provided by RGD
    Official Full Name
    cell division cycle 45provided by RGD
    Primary source
    RGD:1590928
    See related
    EnsemblRapid:ENSRNOG00000070046 AllianceGenome:RGD:1590928
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Cdc45l
    Summary
    Predicted to be involved in DNA unwinding involved in DNA replication. Predicted to be located in centrosome; ciliary basal body; and nucleoplasm. Predicted to be part of CMG complex. Human ortholog(s) of this gene implicated in Meier-Gorlin syndrome 7. Orthologous to human CDC45 (cell division cycle 45). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 75.7), Spleen (RPKM 37.8) and 8 other tissues See more
    Orthologs
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    Genomic context

    See Cdc45 in Genome Data Viewer
    Location:
    11q23
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 11 NC_086029.1 (95689702..95714980)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 11 NC_051346.1 (82185427..82210630)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (86328785..86354099)

    Chromosome 11 - NC_086029.1Genomic Context describing neighboring genes Neighboring gene similar to human chromosome 22 open reading frame 39 Neighboring gene ubiquitin recognition factor in ER associated degradation 1 Neighboring gene claudin 5 Neighboring gene protein phosphatase 2 catalytic subunit alpha like 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Pathways from PubChem

    General gene information

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in DNA unwinding involved in DNA replication  
    involved_in cell division  
    involved_in establishment of blood-retinal barrier  
    involved_in maintenance of blood-brain barrier  
    involved_in negative regulation of angiogenesis  
    involved_in negative regulation of cell migration  
    involved_in negative regulation of gene expression  
    involved_in negative regulation of vascular permeability  
    involved_in positive regulation of bicellular tight junction assembly  
    involved_in positive regulation of cell population proliferation  
    involved_in positive regulation of establishment of endothelial barrier  
    involved_in positive regulation of gene expression  
    involved_in tight junction assembly  
    involved_in transforming growth factor beta receptor signaling pathway  
    Component Evidence Code Pubs
    part_of CMG complex  
    located_in apicolateral plasma membrane  
    located_in bicellular tight junction  
    located_in centrosome  
    located_in centrosome  
    located_in ciliary basal body  
    located_in cortical actin cytoskeleton  
    located_in nucleoplasm  
    located_in nucleus  

    General protein information

    Preferred Names
    cell division control protein 45 homolog
    Names
    CDC45 cell division cycle 45-like
    CDC45-related protein
    cell division cycle 45 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001105866.2NP_001099336.1  cell division control protein 45 homolog

      See identical proteins and their annotated locations for NP_001099336.1

      Status: PROVISIONAL

      Source sequence(s)
      BC161946
      UniProtKB/TrEMBL
      A0A8I6AEM5, A0A8I6AH40, A6JSE8, B1WBZ4
      Conserved Domains (1) summary
      pfam02724
      Location:19565
      CDC45; CDC45-like protein

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086029.1 Reference GRCr8

      Range
      95689702..95714980
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063270326.1XP_063126396.1  cell division control protein 45 homolog isoform X1

      UniProtKB/TrEMBL
      A0A8I6AEM5, A0A8I6AH40, A6JSE8, B1WBZ4
      Related
      ENSRNOP00000092824.2, ENSRNOT00000106544.2

    RNA

    1. XR_005490996.1 RNA Sequence

    2. XR_005490997.2 RNA Sequence

    3. XR_005490998.2 RNA Sequence

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