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    Gtf2e1 general transcription factor IIE subunit 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 303918, updated on 9-Dec-2024

    Summary

    Official Symbol
    Gtf2e1provided by RGD
    Official Full Name
    general transcription factor IIE subunit 1provided by RGD
    Primary source
    RGD:1306851
    See related
    EnsemblRapid:ENSRNOG00000026008 AllianceGenome:RGD:1306851
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable RNA polymerase II general transcription initiation factor activity. Predicted to be involved in transcription initiation at RNA polymerase II promoter. Predicted to be located in cytosol and nucleoplasm. Predicted to be part of transcription factor TFIID complex and transcription factor TFIIE complex. Orthologous to human GTF2E1 (general transcription factor IIE subunit 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 46.1), Kidney (RPKM 40.7) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Gtf2e1 in Genome Data Viewer
    Location:
    11q21
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 11 NC_086029.1 (76687382..76720253)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 11 NC_051346.1 (63182073..63215349)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (66078786..66111394)

    Chromosome 11 - NC_086029.1Genomic Context describing neighboring genes Neighboring gene keratin, type II cytoskeletal 8-like Neighboring gene homogentisate 1, 2-dioxygenase Neighboring gene RAB, member of RAS oncogene family-like 3 Neighboring gene U2 spliceosomal RNA Neighboring gene syntaxin binding protein 5L Neighboring gene ring finger protein 138, pseudogene 4 Neighboring gene DNA polymerase theta

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Pathways from PubChem

    General gene information

    Gene Ontology Provided by RGD

    Component Evidence Code Pubs
    located_in cytosol  
    located_in cytosol  
    located_in nucleoplasm  
    located_in nucleus  
    part_of transcription factor TFIID complex  
    part_of transcription factor TFIIE complex  

    General protein information

    Preferred Names
    general transcription factor IIE subunit 1
    Names
    general transcription factor IIE, polypeptide 1 (alpha subunit)
    general transcription factor IIE, polypeptide 1, alpha

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001100556.1NP_001094026.1  general transcription factor IIE subunit 1

      See identical proteins and their annotated locations for NP_001094026.1

      Status: VALIDATED

      Source sequence(s)
      BC099237, CA509437, DY311373
      UniProtKB/TrEMBL
      A6IR94, G3V992
      Related
      ENSRNOP00000039601.3, ENSRNOT00000042864.6
      Conserved Domains (2) summary
      smart00531
      Location:28175
      TFIIE; Transcription initiation factor IIE
      pfam11521
      Location:393438
      TFIIE-A_C; C-terminal general transcription factor TFIIE alpha

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086029.1 Reference GRCr8

      Range
      76687382..76720253
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039088355.2XP_038944283.1  general transcription factor IIE subunit 1 isoform X1

      UniProtKB/TrEMBL
      A6IR94, G3V992
      Conserved Domains (2) summary
      smart00531
      Location:28175
      TFIIE; Transcription initiation factor IIE
      pfam11521
      Location:393438
      TFIIE-A_C; C-terminal general transcription factor TFIIE alpha
    2. XM_017597999.3XP_017453488.1  general transcription factor IIE subunit 1 isoform X1

      UniProtKB/TrEMBL
      A6IR94, G3V992
      Conserved Domains (2) summary
      smart00531
      Location:28175
      TFIIE; Transcription initiation factor IIE
      pfam11521
      Location:393438
      TFIIE-A_C; C-terminal general transcription factor TFIIE alpha
    3. XM_039088354.2XP_038944282.1  general transcription factor IIE subunit 1 isoform X1

      UniProtKB/TrEMBL
      A6IR94, G3V992
      Conserved Domains (2) summary
      smart00531
      Location:28175
      TFIIE; Transcription initiation factor IIE
      pfam11521
      Location:393438
      TFIIE-A_C; C-terminal general transcription factor TFIIE alpha
    4. XM_008768731.4XP_008766953.1  general transcription factor IIE subunit 1 isoform X1

      See identical proteins and their annotated locations for XP_008766953.1

      UniProtKB/TrEMBL
      A6IR94, G3V992
      Conserved Domains (2) summary
      smart00531
      Location:28175
      TFIIE; Transcription initiation factor IIE
      pfam11521
      Location:393438
      TFIIE-A_C; C-terminal general transcription factor TFIIE alpha
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