Eya1 EYA transcriptional coactivator and phosphatase 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Eya1provided by RGD
Full Name: EYA transcriptional coactivator and phosphatase 1provided by RGD
Primary source: RGD:1584849
See related: EnsemblRapid:ENSRNOG00000007590 AllianceGenome:RGD:1584849
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable RNA binding activity; histone H2AXY142 phosphatase activity; and protein tyrosine phosphatase activity. Predicted to be involved in several processes, including mesodermal cell fate specification; positive regulation of nucleobase-containing compound metabolic process; and protein sumoylation. Predicted to act upstream of or within several processes, including embryonic organ morphogenesis; epithelial cell differentiation; and positive regulation of cell population proliferation. Predicted to be located in cytoplasm and nuclear body. Predicted to be part of protein-DNA complex. Human ortholog(s) of this gene implicated in branchiootorenal syndrome and branchiootorenal syndrome 1. Orthologous to human EYA1 (EYA transcriptional coactivator and phosphatase 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Muscle (RPKM 57.7), Thymus (RPKM 31.9) and 6 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 5q11

Exon count:: 23

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	5	NC_086023.1 (9646599..9884609)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	5	NC_051340.1 (4863501..5101483)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	5	NC_005104.4 (4275728..4495525)

Chromosome 5 - NC_086023.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Downregulation of Eya1 and Six1 gene expression in nitrofen-induced PH suggests that decreased Eya1 and Six1 expression during the late pseudoglandular stage may interfere with epithelial branching and distal airway maturation, thus resulting in PH.
Title: Expression of Eya1 and Six1 is decreased in distal airways of rats with experimental pulmonary hypoplasia.

Submit: New GeneRIF Correction

General gene information

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Markers

BE118841 (e-PCR)
- UniSTS:248896

Eya1 (e-PCR), detects polymorphism
- UniSTS:234058

Eya1 (e-PCR), detects polymorphism
- UniSTS:531335

RH131160 (e-PCR)
- UniSTS:214443

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables RNA binding	ISO Inferred from Sequence Orthology more info
enables histone H2AXY142 phosphatase activity	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables non-membrane spanning protein tyrosine phosphatase activity	IEA Inferred from Electronic Annotation more info
enables protein tyrosine phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein tyrosine phosphatase activity	ISO Inferred from Sequence Orthology more info
enables protein tyrosine phosphatase activity, metal-dependent	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within animal organ morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within aorta morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in biological_process	ND No biological Data available more info
acts_upstream_of_or_within branching involved in ureteric bud morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cell fate commitment	ISO Inferred from Sequence Orthology more info
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cochlea morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in double-strand break repair	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within embryonic skeletal system morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of epithelial cell proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of extrinsic apoptotic signaling pathway in absence of ligand	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within inner ear morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in mesodermal cell fate specification	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within metanephros development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within middle ear morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of extrinsic apoptotic signaling pathway in absence of ligand	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative regulation of extrinsic apoptotic signaling pathway in absence of ligand	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within neuron fate specification	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within otic vesicle development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within otic vesicle morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within outer ear morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within outflow tract morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within pattern specification process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within pharyngeal system development	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA repair	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of DNA repair	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of epithelial cell proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of secondary heart field cardioblast proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein dephosphorylation	ISO Inferred from Sequence Orthology more info
involved_in protein sumoylation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of neuron differentiation	ISO Inferred from Sequence Orthology more info
involved_in response to ionizing radiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within semicircular canal morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within striated muscle tissue development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within ureteric bud development	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in nuclear body	IEA Inferred from Electronic Annotation more info
located_in nuclear body	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
part_of protein-DNA complex	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: eyes absent homolog 1

Names: eyes absent 1 homolog

NP_001413950.1

EC 3.1.3.48

XP_038966833.1

EC 3.1.3.48

XP_038966834.1

EC 3.1.3.48

XP_038966835.1

EC 3.1.3.48

XP_038966836.1

EC 3.1.3.48

XP_038966837.1

EC 3.1.3.48

XP_038966839.1

EC 3.1.3.48

XP_038966840.1

EC 3.1.3.48

XP_038966841.1

EC 3.1.3.48

XP_038966842.1

EC 3.1.3.48

XP_038966844.1

EC 3.1.3.48

XP_063144376.1

EC 3.1.3.48

XP_063144377.1

EC 3.1.3.48

XP_063144378.1

EC 3.1.3.48

XP_063144379.1

EC 3.1.3.48

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001427021.1 → NP_001413950.1 eyes absent homolog 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000005

UniProtKB/TrEMBL

A0A0G2JWT3

Related

ENSRNOP00000063439.5, ENSRNOT00000064946.6

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086023.1 Reference GRCr8

Range

9646599..9884609

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039110907.2 → XP_038966835.1 eyes absent homolog 1 isoform X3

UniProtKB/TrEMBL

A0A0G2JWT3

Conserved Domains (2) summary

cd02601
Location:382 → 653

HAD_Eya; protein tyrosine phosphatase domain of the nuclear transcription factor of Eyes absent (Eya) and related phosphatase domains

pfam15967
Location:149 → 286

Nucleoporin_FG2; Nucleoporin FG repeated region
XM_039110905.2 → XP_038966833.1 eyes absent homolog 1 isoform X1

UniProtKB/TrEMBL

A0A0G2JWT3

Related

ENSRNOP00000098325.2, ENSRNOT00000120693.2

Conserved Domains (1) summary

cd02601
Location:387 → 658

HAD_Eya; protein tyrosine phosphatase domain of the nuclear transcription factor of Eyes absent (Eya) and related phosphatase domains
XM_039110909.2 → XP_038966837.1 eyes absent homolog 1 isoform X5

UniProtKB/TrEMBL

A0A0G2JWT3

Related

ENSRNOP00000098324.2, ENSRNOT00000120692.2

Conserved Domains (1) summary

cd02601
Location:389 → 630

HAD_Eya; protein tyrosine phosphatase domain of the nuclear transcription factor of Eyes absent (Eya) and related phosphatase domains
XM_039110906.2 → XP_038966834.1 eyes absent homolog 1 isoform X2

UniProtKB/TrEMBL

A0A0G2JWT3

Conserved Domains (1) summary

cd02601
Location:386 → 657

HAD_Eya; protein tyrosine phosphatase domain of the nuclear transcription factor of Eyes absent (Eya) and related phosphatase domains
XM_039110908.2 → XP_038966836.1 eyes absent homolog 1 isoform X4

UniProtKB/TrEMBL

A0A0G2JWT3

Conserved Domains (2) summary

pfam05109
Location:98 → 339

Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)

cd02601
Location:381 → 652

HAD_Eya; protein tyrosine phosphatase domain of the nuclear transcription factor of Eyes absent (Eya) and related phosphatase domains
XM_039110913.2 → XP_038966841.1 eyes absent homolog 1 isoform X6

UniProtKB/TrEMBL

A0A0G2JWT3, D3ZVI5

Conserved Domains (2) summary

pfam05109
Location:31 → 279

Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)

cd02601
Location:321 → 592

HAD_Eya; protein tyrosine phosphatase domain of the nuclear transcription factor of Eyes absent (Eya) and related phosphatase domains
XM_039110911.2 → XP_038966839.1 eyes absent homolog 1 isoform X7

UniProtKB/TrEMBL

A0A0G2JWT3

Related

ENSRNOP00000070005.3, ENSRNOT00000082717.4

Conserved Domains (2) summary

pfam05109
Location:11 → 246

Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)

cd02601
Location:288 → 559

HAD_Eya; protein tyrosine phosphatase domain of the nuclear transcription factor of Eyes absent (Eya) and related phosphatase domains
XM_063288309.1 → XP_063144379.1 eyes absent homolog 1 isoform X9

UniProtKB/TrEMBL

A0A0G2JWT3
XM_063288308.1 → XP_063144378.1 eyes absent homolog 1 isoform X8

UniProtKB/TrEMBL

A0A0G2JWT3

Related

ENSRNOP00000098327.2, ENSRNOT00000120695.2
XM_039110912.2 → XP_038966840.1 eyes absent homolog 1 isoform X7

UniProtKB/TrEMBL

A0A0G2JWT3

Conserved Domains (2) summary

pfam05109
Location:11 → 246

Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)

cd02601
Location:288 → 559

HAD_Eya; protein tyrosine phosphatase domain of the nuclear transcription factor of Eyes absent (Eya) and related phosphatase domains
XM_063288306.1 → XP_063144376.1 eyes absent homolog 1 isoform X6

UniProtKB/TrEMBL

A0A0G2JWT3, D3ZVI5

Related

ENSRNOP00000098326.2, ENSRNOT00000120694.2
XM_063288307.1 → XP_063144377.1 eyes absent homolog 1 isoform X7

UniProtKB/TrEMBL

A0A0G2JWT3
XM_039110914.2 → XP_038966842.1 eyes absent homolog 1 isoform X10

UniProtKB/TrEMBL

A0A0G2JWT3

Conserved Domains (1) summary

cd02601
Location:204 → 475

HAD_Eya; protein tyrosine phosphatase domain of the nuclear transcription factor of Eyes absent (Eya) and related phosphatase domains
XM_039110916.2 → XP_038966844.1 eyes absent homolog 1 isoform X11

UniProtKB/TrEMBL

A0A0G2JWT3

Conserved Domains (1) summary

cd02601
Location:199 → 470

HAD_Eya; protein tyrosine phosphatase domain of the nuclear transcription factor of Eyes absent (Eya) and related phosphatase domains