Sh3glb1 SH3 domain -containing GRB2-like endophilin B1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Sh3glb1provided by RGD
Official Full Name: SH3 domain -containing GRB2-like endophilin B1provided by RGD
Primary source: RGD:1304859
See related: EnsemblRapid:ENSRNOG00000012957 AllianceGenome:RGD:1304859
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable several functions, including lysophosphatidic acid acyltransferase activity; phosphatidylinositol 3-kinase activator activity; and protein homodimerization activity. Involved in positive regulation of neurotrophin TRK receptor signaling pathway; regulation of cell morphogenesis; and regulation of early endosome to late endosome transport. Located in early endosome; neuronal cell body; and synaptic vesicle. Orthologous to human SH3GLB1 (SH3 domain containing GRB2 like, endophilin B1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Muscle (RPKM 645.7), Heart (RPKM 635.2) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 2q44

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	2	NC_086020.1 (236411194..236445225, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	2	NC_051337.1 (233750838..233784817, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	2	NC_005101.4 (250709812..250744216, complement)

Chromosome 2 - NC_086020.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Bif-1 was implicated as a novel target of cerebral ischemia reperfusion injury and played a neuroprotective role by promoting cell survival.
Title: Overexpression Bax interacting factor-1 protects cortical neurons against cerebral ischemia-reperfusion injury through regulation of ERK1/2 pathway.
DLP1 also caused global morphological changes in mitochondrial outer membrane-like liposomes, but DLP1 did not stimulate BAX-permeabilizing function in the absence or presence of Bif-1.
Title: Endophilin B1/Bif-1 stimulates BAX activation independently from its capacity to produce large scale membrane morphological rearrangements.
We propose syndapin and endophilin function either at different stages during SVE or in mechanistically distinct types of SVE.
Title: Syndapin I and endophilin I bind overlapping proline-rich regions of dynamin I: role in synaptic vesicle endocytosis.
N-BAR domains of endophilin function as low-affinity dimers regulating binding partner recruitment to areas of high membrane curvature.
Title: Mechanism of endophilin N-BAR domain-mediated membrane curvature.
Overall, the discovery of endophilin as a partner for VGLUT1 in nerve terminals strongly suggests the existence of functional differences between VGLUT1 and -2 terminals in their abilities to replenish vesicle pools.
Title: Interaction between the vesicular glutamate transporter type 1 and endophilin A1, a protein essential for endocytosis.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables fatty acid binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables lipid binding	IEA Inferred from Electronic Annotation more info
enables lysophosphatidic acid acyltransferase activity	ISO Inferred from Sequence Orthology more info
enables phosphatidylinositol 3-kinase activator activity	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein homodimerization activity	IEA Inferred from Electronic Annotation more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within 'de novo' post-translational protein folding	ISO Inferred from Sequence Orthology more info
involved_in apoptotic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in autophagic cell death	IEA Inferred from Electronic Annotation more info
involved_in autophagic cell death	ISO Inferred from Sequence Orthology more info
involved_in cellular response to amino acid starvation	IEA Inferred from Electronic Annotation more info
involved_in cellular response to amino acid starvation	ISO Inferred from Sequence Orthology more info
involved_in cellular response to glucose starvation	IEA Inferred from Electronic Annotation more info
involved_in cellular response to glucose starvation	ISO Inferred from Sequence Orthology more info
involved_in membrane fission	IEA Inferred from Electronic Annotation more info
involved_in membrane fission	ISO Inferred from Sequence Orthology more info
involved_in membrane organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitochondrion organization	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within phosphatidic acid biosynthetic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within phospholipid biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of autophagosome assembly	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of autophagosome assembly	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of autophagy	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of dendrite extension	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of dendrite morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of establishment of protein localization to mitochondrion	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of membrane tubulation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of membrane tubulation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of neurotrophin TRK receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of protein targeting to mitochondrion	ISO Inferred from Sequence Orthology more info	PubMed
involved_in positive regulation of protein-containing complex assembly	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of protein-containing complex assembly	ISO Inferred from Sequence Orthology more info
involved_in protein localization to vacuolar membrane	IEA Inferred from Electronic Annotation more info
involved_in protein localization to vacuolar membrane	ISO Inferred from Sequence Orthology more info
involved_in receptor catabolic process	IEA Inferred from Electronic Annotation more info
involved_in receptor catabolic process	ISO Inferred from Sequence Orthology more info
involved_in regulation of cytokinesis	IEA Inferred from Electronic Annotation more info
involved_in regulation of cytokinesis	ISO Inferred from Sequence Orthology more info
involved_in regulation of early endosome to late endosome transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of protein stability	ISO Inferred from Sequence Orthology more info	PubMed

Component	Evidence Code	Pubs
located_in Golgi membrane	IEA Inferred from Electronic Annotation more info
located_in autophagosome membrane	IEA Inferred from Electronic Annotation more info
located_in autophagosome membrane	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in early endosome	IDA Inferred from Direct Assay more info	PubMed
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in midbody	IEA Inferred from Electronic Annotation more info
located_in midbody	ISO Inferred from Sequence Orthology more info
located_in mitochondrial outer membrane	IEA Inferred from Electronic Annotation more info
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
part_of protein-containing complex	IEA Inferred from Electronic Annotation more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info
located_in synapse	IEA Inferred from Electronic Annotation more info
located_in synaptic vesicle	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: endophilin-B1

Names: SH3 domain-containing GRB2-like protein B1; SH3-domain GRB2-like B1 (endophilin); SH3-domain GRB2-like endophilin B1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001011929.1 → NP_001011929.1 endophilin-B1

See identical proteins and their annotated locations for NP_001011929.1

Status: PROVISIONAL

Source sequence(s)

BC079085

UniProtKB/Swiss-Prot

Q6AYE2

UniProtKB/TrEMBL

A0A8I6ADA0

Related

ENSRNOP00000092051.1, ENSRNOT00000098552.2

Conserved Domains (2) summary

cd07616
Location:24 → 252

BAR_Endophilin_B1; The Bin/Amphiphysin/Rvs (BAR) domain of Endophilin-B1

cd11945
Location:305 → 365

SH3_Endophilin_B1; Src homology 3 domain of Endophilin-B1

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086020.1 Reference GRCr8

Range

236411194..236445225 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039101876.2 → XP_038957804.1 endophilin-B1 isoform X7

UniProtKB/TrEMBL

A0A0G2K714, A0A8I6ADA0

Related

ENSRNOP00000017771.5, ENSRNOT00000017770.7

Conserved Domains (2) summary

cd07616
Location:24 → 252

BAR_Endophilin_B1; The Bin/Amphiphysin/Rvs (BAR) domain of Endophilin-B1

cl17036
Location:305 → 355

SH3; Src Homology 3 domain superfamily
XM_006233435.5 → XP_006233497.1 endophilin-B1 isoform X8

UniProtKB/TrEMBL

A0A8I5ZL78, A0A8I6ADA0

Related

ENSRNOP00000078654.1, ENSRNOT00000109147.2

Conserved Domains (2) summary

cd07616
Location:24 → 252

BAR_Endophilin_B1; The Bin/Amphiphysin/Rvs (BAR) domain of Endophilin-B1

cl17036
Location:305 → 330

SH3; Src Homology 3 domain superfamily
XM_017590682.3 → XP_017446171.1 endophilin-B1 isoform X5

UniProtKB/TrEMBL

A0A8I6ADA0

Conserved Domains (2) summary

cd07616
Location:24 → 289

BAR_Endophilin_B1; The Bin/Amphiphysin/Rvs (BAR) domain of Endophilin-B1

cl17036
Location:342 → 367

SH3; Src Homology 3 domain superfamily
XM_017590681.3 → XP_017446170.1 endophilin-B1 isoform X3

UniProtKB/TrEMBL

A0A8I6ADA0

Conserved Domains (2) summary

cd07616
Location:24 → 289

BAR_Endophilin_B1; The Bin/Amphiphysin/Rvs (BAR) domain of Endophilin-B1

cl17036
Location:342 → 392

SH3; Src Homology 3 domain superfamily
XM_006233433.5 → XP_006233495.1 endophilin-B1 isoform X4

UniProtKB/TrEMBL

A0A8I6ADA0

Conserved Domains (2) summary

cd07616
Location:24 → 273

BAR_Endophilin_B1; The Bin/Amphiphysin/Rvs (BAR) domain of Endophilin-B1

cd11945
Location:326 → 386

SH3_Endophilin_B1; Src homology 3 domain of Endophilin-B1
XM_006233431.5 → XP_006233493.1 endophilin-B1 isoform X2

UniProtKB/TrEMBL

A0A8I6ADA0, A0A8I6AKY2

Related

ENSRNOP00000093719.1, ENSRNOT00000104475.2

Conserved Domains (2) summary

cd07616
Location:24 → 289

BAR_Endophilin_B1; The Bin/Amphiphysin/Rvs (BAR) domain of Endophilin-B1

cd11945
Location:342 → 402

SH3_Endophilin_B1; Src homology 3 domain of Endophilin-B1
XM_063281446.1 → XP_063137516.1 endophilin-B1 isoform X6

UniProtKB/TrEMBL

A6HW96
XM_063281445.1 → XP_063137515.1 endophilin-B1 isoform X1

UniProtKB/TrEMBL

A0A8I6ADA0