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    Doc2g double C2-like domains, gamma [ Rattus norvegicus (Norway rat) ]

    Gene ID: 293654, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Doc2gprovided by RGD
    Official Full Name
    double C2-like domains, gammaprovided by RGD
    Primary source
    RGD:1307473
    See related
    EnsemblRapid:ENSRNOG00000018029 AllianceGenome:RGD:1307473
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Doc2gp
    Summary
    Predicted to enable metal ion binding activity. Predicted to be involved in calcium-dependent activation of synaptic vesicle fusion and positive regulation of calcium ion-dependent exocytosis. Predicted to be located in membrane and presynapse. Predicted to be active in synapse. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Heart (RPKM 184.2), Muscle (RPKM 22.8) and 6 other tissues See more
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    Genomic context

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    See Doc2g in Genome Data Viewer
    Location:
    1q43
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (210724868..210729352)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (201295377..201299867)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (219249253..219253790)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene aminoacylase 3 Neighboring gene T-box transcription factor 10 Neighboring gene nudix hydrolase 8 Neighboring gene NADH:ubiquinone oxidoreductase core subunit V1 Neighboring gene uncharacterized LOC134483955 Neighboring gene glutathione S-transferase pi 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in presynapse IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    double C2-like domain-containing protein gamma
    Names
    double C2, gamma

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001011937.1 → NP_001011937.1  double C2-like domain-containing protein gamma

      See identical proteins and their annotated locations for NP_001011937.1

      Status: PROVISIONAL

      Source sequence(s)
      BC083779
      UniProtKB/TrEMBL
      A6HYQ9, A6HYR0, F7ES77, Q5XIA7
      Related
      ENSRNOP00000101101.1, ENSRNOT00000147649.1
      Conserved Domains (2) summary
      cd04035
      Location:84 → 209
      C2A_Rabphilin_Doc2; C2 domain first repeat present in Rabphilin and Double C2 domain
      cl14603
      Location:246 → 378
      C2; C2 domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      210724868..210729352
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006230735.5 → XP_006230797.1  double C2-like domain-containing protein gamma isoform X1

      UniProtKB/TrEMBL
      A6HYR0
      Related
      ENSRNOP00000024353.5, ENSRNOT00000024353.7
      Conserved Domains (2) summary
      cd04035
      Location:84 → 211
      C2A_Rabphilin_Doc2; C2 domain first repeat present in Rabphilin and Double C2 domain
      cl14603
      Location:248 → 380
      C2; C2 domain
    Nucleotide Protein Strain
    Heading Accession and Version

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