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    Clic4 chloride intracellular channel 4 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 83718, updated on 9-Dec-2024

    Summary

    Official Symbol
    Clic4provided by RGD
    Official Full Name
    chloride intracellular channel 4provided by RGD
    Primary source
    RGD:61857
    See related
    EnsemblRapid:ENSRNOG00000018109 AllianceGenome:RGD:61857
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables chloride channel activity. Predicted to be involved in several processes, including cellular response to calcium ion; chloride transport; and keratinocyte differentiation. Predicted to act upstream of or within several processes, including endothelial cell morphogenesis; vacuolar acidification; and vasculature development. Located in mitochondrial outer membrane. Orthologous to human CLIC4 (chloride intracellular channel 4). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Heart (RPKM 1064.7), Kidney (RPKM 906.2) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Clic4 in Genome Data Viewer
    Location:
    5q36
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (152737371..152797118, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (147453702..147513455, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (153568937..153625669, complement)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene RUNX family transcription factor 3 Neighboring gene uncharacterized LOC134487009 Neighboring gene uncharacterized LOC134479039 Neighboring gene uncharacterized LOC120103007 Neighboring gene serine and arginine repetitive matrix 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables chloride channel activity  
    enables chloride channel activity PubMed 
    enables chloride channel activity  
    enables oxidoreductase activity  
    enables protein binding PubMed 
    enables protein-containing complex binding PubMed 
    Process Evidence Code Pubs
    involved_in angiogenesis  
    acts_upstream_of_or_within angiogenesis  
    involved_in branching morphogenesis of an epithelial tube  
    acts_upstream_of_or_within branching morphogenesis of an epithelial tube  
    involved_in cellular response to calcium ion  
    involved_in chloride transmembrane transport  
    involved_in chloride transport  
    involved_in chloride transport PubMed 
    involved_in endothelial cell morphogenesis  
    acts_upstream_of_or_within endothelial cell morphogenesis  
    involved_in fertilization  
    acts_upstream_of_or_within fertilization  
    involved_in keratinocyte differentiation  
    involved_in keratinocyte differentiation  
    involved_in multicellular organism growth  
    acts_upstream_of_or_within multicellular organism growth  
    involved_in negative regulation of cell migration  
    involved_in negative regulation of cell migration  
    involved_in retina vasculature morphogenesis in camera-type eye  
    acts_upstream_of_or_within retina vasculature morphogenesis in camera-type eye  
    involved_in vacuolar acidification  
    acts_upstream_of_or_within vacuolar acidification  
    Items 1 - 20 of 27
    Component Evidence Code Pubs
    located_in anchoring junction  
    located_in apical part of cell  
    located_in cell surface  
    located_in cell-cell junction  
    located_in centrosome  
    located_in centrosome  
    part_of chloride channel complex  
    is_active_in cytoplasm  
    located_in cytoplasm  
    located_in cytoplasm  
    located_in cytoplasmic vesicle membrane  
    located_in cytosol  
    located_in endoplasmic reticulum PubMed 
    located_in endoplasmic reticulum membrane  
    is_active_in membrane  
    located_in microtubule cytoskeleton  
    located_in microvillus  
    located_in midbody  
    located_in mitochondrial outer membrane PubMed 
    located_in mitochondrion  
    located_in mitochondrion  
    located_in nuclear matrix  
    located_in nucleus  
    located_in perinuclear region of cytoplasm  
    located_in plasma membrane  
    located_in plasma membrane  
    located_in vesicle PubMed 
    Items 1 - 20 of 27

    General protein information

    Preferred Names
    chloride intracellular channel protein 4
    Names
    chloride intracellular channel 4 (mitochondrial)
    glutaredoxin-like oxidoreductase CLIC4
    intracellular chloride ion channel protein p64H1
    mitochondrial chloride intracellular channel 4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_031818.2NP_114006.2  chloride intracellular channel protein 4

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/Swiss-Prot
      Q9Z0W7
      UniProtKB/TrEMBL
      A3FM27, A6IT49, G3V8C4
      Related
      ENSRNOP00000024464.1, ENSRNOT00000024464.6

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      152737371..152797118 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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