U.S. flag

An official website of the United States government

Links from GEO Profiles

    • Showing Current items.

    Il10ra interleukin 10 receptor subunit alpha [ Rattus norvegicus (Norway rat) ]

    Gene ID: 117539, updated on 9-Dec-2024

    Summary

    Official Symbol
    Il10raprovided by RGD
    Official Full Name
    interleukin 10 receptor subunit alphaprovided by RGD
    Primary source
    RGD:620138
    See related
    EnsemblRapid:ENSRNOG00000016308 AllianceGenome:RGD:620138
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables interleukin-10 binding activity and interleukin-10 receptor activity. Involved in regulation of synapse organization and response to lipopolysaccharide. Predicted to be located in cytosol. Predicted to be active in apical plasma membrane. Human ortholog(s) of this gene implicated in inflammatory bowel disease 28. Orthologous to human IL10RA (interleukin 10 receptor subunit alpha). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Spleen (RPKM 128.7), Lung (RPKM 47.2) and 8 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Il10ra in Genome Data Viewer
    Location:
    8q22
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (54459754..54474786, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (45563009..45578041, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (49558062..49573891, complement)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene transmembrane serine protease 4 Neighboring gene small integral membrane protein 35 Neighboring gene uncharacterized LOC120094136 Neighboring gene glutathione S-transferase pi 1, pseudogene 4 Neighboring gene transmembrane serine protease 13

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables interleukin-10 binding PubMed 
    enables interleukin-10 binding PubMed 
    enables interleukin-10 receptor activity  
    enables interleukin-10 receptor activity PubMed 
    enables interleukin-10 receptor activity  
    Component Evidence Code Pubs
    is_active_in apical plasma membrane  
    located_in cytosol  
    located_in cytosol  
    is_active_in plasma membrane  
    located_in plasma membrane  

    General protein information

    Preferred Names
    interleukin-10 receptor subunit alpha
    Names
    interleukin 10 receptor, alpha

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_057193.2 → NP_476541.2  interleukin-10 receptor subunit alpha

      See identical proteins and their annotated locations for NP_476541.2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/TrEMBL
      A6J435, G3V830, Q99ND6
      Related
      ENSRNOP00000021926.2, ENSRNOT00000021926.6
      Conserved Domains (1) summary
      pfam01108
      Location:5 → 113
      Tissue_fac; Tissue factor

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      54459754..54474786 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039080716.2 → XP_038936644.1  interleukin-10 receptor subunit alpha isoform X1

    External link. Please review our privacy policy.