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    Derl1 derlin 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 362912, updated on 9-Dec-2024

    Summary

    Official Symbol
    Derl1provided by RGD
    Official Full Name
    derlin 1provided by RGD
    Primary source
    RGD:1311835
    See related
    EnsemblRapid:ENSRNOG00000005551 AllianceGenome:RGD:1311835
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1311835
    Summary
    Predicted to enable several functions, including enzyme binding activity; identical protein binding activity; and signal recognition particle binding activity. Predicted to be involved in several processes, including endoplasmic reticulum unfolded protein response; proteasomal protein catabolic process; and protein destabilization. Predicted to act upstream of or within cellular response to unfolded protein and retrograde protein transport, ER to cytosol. Predicted to be located in endoplasmic reticulum quality control compartment; endosome; and membrane. Predicted to be part of Derlin-1 retrotranslocation complex and Derlin-1-VIMP complex. Predicted to be active in endoplasmic reticulum membrane. Orthologous to human DERL1 (derlin 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Adrenal (RPKM 221.4), Liver (RPKM 216.3) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Derl1 in Genome Data Viewer
    Location:
    7q33
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (91293963..91316639, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (89404413..89427095, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (97737176..97759852, complement)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene U6 spliceosomal RNA Neighboring gene zinc fingers and homeoboxes 2 Neighboring gene uncharacterized LOC102553568 Neighboring gene uncharacterized LOC134479907 Neighboring gene ribosomal protein L37A, pseudogene 14 Neighboring gene TBC1 domain family, member 31

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Interactions

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATPase binding  
    enables MHC class I protein binding  
    enables identical protein binding  
    enables protease binding  
    enables protein-containing complex binding  
    enables signal recognition particle binding  
    enables ubiquitin protein ligase binding  
    enables ubiquitin-specific protease binding  
    Component Evidence Code Pubs
    part_of Derlin-1 retrotranslocation complex  
    part_of Derlin-1-VIMP complex  
    located_in early endosome  
    located_in endoplasmic reticulum  
    located_in endoplasmic reticulum membrane  
    located_in endoplasmic reticulum quality control compartment  
    located_in late endosome  
    located_in membrane  

    General protein information

    Preferred Names
    derlin-1
    Names
    Der1-like domain family, member 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001014202.1NP_001014224.1  derlin-1

      See identical proteins and their annotated locations for NP_001014224.1

      Status: PROVISIONAL

      Source sequence(s)
      BC085877
      UniProtKB/TrEMBL
      A0A8I6AIT0, A0A9K3Y8E4, F7FNS3, Q5RKH9
      Related
      ENSRNOP00000007484.5, ENSRNOT00000007484.7
      Conserved Domains (1) summary
      pfam04511
      Location:11204
      DER1; Der1-like family

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      91293963..91316639 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039079517.2XP_038935445.1  derlin-1 isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZMS4
      Conserved Domains (1) summary
      cl21536
      Location:1104
      Rhomboid; Rhomboid family
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