Zfp133 zinc finger protein 133 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Zfp133provided by RGD
Official Full Name: zinc finger protein 133provided by RGD
Primary source: RGD:1566283
See related: EnsemblRapid:ENSRNOG00000027955 AllianceGenome:RGD:1566283
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Znf133
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Orthologous to human ZNF133 (zinc finger protein 133). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Muscle (RPKM 69.1), Lung (RPKM 67.4) and 9 other tissues See more
Orthologs: human all
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Genomic context

Location:: 3q41

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (152282744..152300892)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (131829404..131847552)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (138597638..138616133)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: zinc finger protein 133

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001024313.1 → NP_001019484.2 zinc finger protein 133

Status: VALIDATED

Source sequence(s)

BC079070

UniProtKB/TrEMBL

F7FQD8

Related

ENSRNOP00000038318.4, ENSRNOT00000031623.5

Conserved Domains (6) summary

smart00349
Location:21 → 80

KRAB; krueppel associated box

COG5048
Location:235 → 530

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:292 → 312

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam00096
Location:487 → 508

zf-C2H2; Zinc finger, C2H2 type

pfam01352
Location:21 → 60

KRAB; KRAB box

pfam13465
Location:332 → 357

zf-H2C2_2; Zinc-finger double domain