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    Notch4 notch receptor 4 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 406162, updated on 9-Dec-2024

    Summary

    Official Symbol
    Notch4provided by RGD
    Official Full Name
    notch receptor 4provided by RGD
    Primary source
    RGD:1303282
    See related
    EnsemblRapid:ENSRNOG00000000442 AllianceGenome:RGD:1303282
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific; Notch binding activity; and cis-regulatory region sequence-specific DNA binding activity. Involved in endothelial cell morphogenesis and luteolysis. Predicted to be located in cell surface; cytoplasmic vesicle; and endoplasmic reticulum. Human ortholog(s) of this gene implicated in autoimmune disease (multiple); dementia; ductal carcinoma in situ; schizophrenia; and systemic scleroderma. Orthologous to human NOTCH4 (notch receptor 4). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Lung (RPKM 59.6), Heart (RPKM 41.6) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Notch4 in Genome Data Viewer
    Location:
    20p12
    Exon count:
    30
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 20 NC_086038.1 (4164969..4189072, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 20 NC_051355.1 (4160362..4184466, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 20 NC_005119.4 (4329794..4353868)

    Chromosome 20 - NC_086038.1Genomic Context describing neighboring genes Neighboring gene PBX homeobox 2 Neighboring gene G-protein signaling modulator 3 Neighboring gene serine/threonine kinase 19 pseudogene Neighboring gene complement C4B

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    General gene information

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in Notch signaling pathway  
    involved_in branching involved in blood vessel morphogenesis  
    involved_in endothelial cell differentiation PubMed 
    involved_in endothelial cell morphogenesis PubMed 
    involved_in epithelial to mesenchymal transition  
    involved_in luteolysis PubMed 
    involved_in mammary gland development  
    involved_in morphogenesis of a branching structure  
    acts_upstream_of_or_within negative regulation of Notch signaling pathway  
    involved_in negative regulation of cell adhesion molecule production  
    involved_in negative regulation of cell-cell adhesion mediated by cadherin  
    involved_in negative regulation of endothelial cell differentiation  
    involved_in negative regulation of transcription by RNA polymerase II  
    acts_upstream_of_or_within positive regulation of angiogenesis  
    acts_upstream_of_or_within positive regulation of aorta morphogenesis  
    involved_in positive regulation of smooth muscle cell differentiation  
    involved_in positive regulation of transcription by RNA polymerase II  
    acts_upstream_of_or_within regulation of Notch signaling pathway  
    acts_upstream_of_or_within regulation of protein localization  
    acts_upstream_of_or_within regulation of protein processing  
    involved_in vasculature development  
    acts_upstream_of_or_within venous blood vessel morphogenesis  
    Component Evidence Code Pubs
    located_in cell surface  
    located_in cytoplasmic vesicle  
    located_in endoplasmic reticulum  
    located_in nucleus  
    located_in plasma membrane  

    General protein information

    Preferred Names
    neurogenic locus notch homolog protein 4
    Names
    notch 4

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001002827.1 → NP_001002827.1  neurogenic locus notch homolog protein 4 precursor

      See identical proteins and their annotated locations for NP_001002827.1

      Status: PROVISIONAL

      Source sequence(s)
      BX883044
      UniProtKB/TrEMBL
      A6KTE6, A6KTE7, F7EQS6, Q6MG89
      Related
      ENSRNOP00000000513.4, ENSRNOT00000000513.6
      Conserved Domains (8) summary
      cd00054
      Location:429 → 470
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      cd00204
      Location:1625 → 1732
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam00066
      Location:1245 → 1281
      Notch; LNR domain
      pfam06816
      Location:1291 → 1337
      NOD; NOTCH protein
      pfam07645
      Location:191 → 224
      EGF_CA; Calcium-binding EGF domain
      pfam07684
      Location:1376 → 1415
      NODP; NOTCH protein
      pfam12796
      Location:1630 → 1723
      Ank_2; Ankyrin repeats (3 copies)
      sd00045
      Location:1626 → 1656
      ANK; ANK repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086038.1 Reference GRCr8

      Range
      4164969..4189072 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039098929.1 → XP_038954857.1  neurogenic locus notch homolog protein 4 isoform X4

      Conserved Domains (9) summary
      smart00004
      Location:771 → 809
      NL; Domain found in Notch and Lin-12
      COG0666
      Location:1205 → 1387
      ANKYR; Ankyrin repeat [Signal transduction mechanisms]
      cd00054
      Location:116 → 152
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      sd00045
      Location:1194 → 1224
      ANK; ANK repeat [structural motif]
      pfam00008
      Location:298 → 328
      EGF; EGF-like domain
      pfam00066
      Location:819 → 848
      Notch; LNR domain
      pfam06816
      Location:859 → 908
      NOD; NOTCH protein
      pfam12796
      Location:1198 → 1291
      Ank_2; Ankyrin repeats (3 copies)
      cd21705
      Location:1004 → 1079
      JMTM_Notch4; juxtamembrane and transmembrane (JMTM) domain found in neurogenic locus notch homolog protein 4 (Notch4) and similar proteins
    2. XM_039098927.1 → XP_038954855.1  neurogenic locus notch homolog protein 4 isoform X2

      Conserved Domains (10) summary
      smart00004
      Location:779 → 817
      NL; Domain found in Notch and Lin-12
      COG0666
      Location:1213 → 1395
      ANKYR; Ankyrin repeat [Signal transduction mechanisms]
      PRK07003
      Location:10 → 183
      PRK07003; DNA polymerase III subunit gamma/tau
      cd00054
      Location:542 → 576
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      sd00045
      Location:1202 → 1232
      ANK; ANK repeat [structural motif]
      pfam00008
      Location:306 → 336
      EGF; EGF-like domain
      pfam00066
      Location:827 → 856
      Notch; LNR domain
      pfam06816
      Location:867 → 916
      NOD; NOTCH protein
      pfam12796
      Location:1206 → 1299
      Ank_2; Ankyrin repeats (3 copies)
      cd21705
      Location:1012 → 1087
      JMTM_Notch4; juxtamembrane and transmembrane (JMTM) domain found in neurogenic locus notch homolog protein 4 (Notch4) and similar proteins
    3. XM_039098930.2 → XP_038954858.1  neurogenic locus notch homolog protein 4 isoform X5

      Conserved Domains (9) summary
      smart00004
      Location:736 → 774
      NL; Domain found in Notch and Lin-12
      COG0666
      Location:1170 → 1352
      ANKYR; Ankyrin repeat [Signal transduction mechanisms]
      cd00054
      Location:499 → 533
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      sd00045
      Location:1159 → 1189
      ANK; ANK repeat [structural motif]
      pfam00008
      Location:263 → 293
      EGF; EGF-like domain
      pfam00066
      Location:784 → 813
      Notch; LNR domain
      pfam06816
      Location:824 → 873
      NOD; NOTCH protein
      pfam12796
      Location:1163 → 1256
      Ank_2; Ankyrin repeats (3 copies)
      cd21705
      Location:969 → 1044
      JMTM_Notch4; juxtamembrane and transmembrane (JMTM) domain found in neurogenic locus notch homolog protein 4 (Notch4) and similar proteins
    4. XM_039098926.2 → XP_038954854.1  neurogenic locus notch homolog protein 4 isoform X1

      UniProtKB/TrEMBL
      A6KTE7
      Conserved Domains (8) summary
      smart00004
      Location:1203 → 1241
      NL; Domain found in Notch and Lin-12
      cd00054
      Location:429 → 470
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      sd00045
      Location:1626 → 1656
      ANK; ANK repeat [structural motif]
      pfam07645
      Location:191 → 224
      EGF_CA; Calcium-binding EGF domain
      pfam00066
      Location:1251 → 1280
      Notch; LNR domain
      pfam06816
      Location:1291 → 1340
      NOD; NOTCH protein
      pfam12796
      Location:1630 → 1723
      Ank_2; Ankyrin repeats (3 copies)
      cd21705
      Location:1436 → 1511
      JMTM_Notch4; juxtamembrane and transmembrane (JMTM) domain found in neurogenic locus notch homolog protein 4 (Notch4) and similar proteins
    5. XM_039098928.2 → XP_038954856.1  neurogenic locus notch homolog protein 4 isoform X3

      UniProtKB/TrEMBL
      A6KTE7
      Conserved Domains (6) summary
      smart00004
      Location:1203 → 1241
      NL; Domain found in Notch and Lin-12
      cd00054
      Location:429 → 470
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      pfam07645
      Location:191 → 224
      EGF_CA; Calcium-binding EGF domain
      pfam00066
      Location:1251 → 1280
      Notch; LNR domain
      pfam06816
      Location:1291 → 1340
      NOD; NOTCH protein
      cd21705
      Location:1436 → 1511
      JMTM_Notch4; juxtamembrane and transmembrane (JMTM) domain found in neurogenic locus notch homolog protein 4 (Notch4) and similar proteins
    6. XM_039098931.2 → XP_038954859.1  neurogenic locus notch homolog protein 4 isoform X6

      UniProtKB/TrEMBL
      A6KTE8
      Conserved Domains (5) summary
      smart00004
      Location:1203 → 1241
      NL; Domain found in Notch and Lin-12
      cd00054
      Location:429 → 470
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      pfam07645
      Location:191 → 224
      EGF_CA; Calcium-binding EGF domain
      pfam00066
      Location:1251 → 1280
      Notch; LNR domain
      pfam06816
      Location:1291 → 1340
      NOD; NOTCH protein
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