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    Tra2a transformer 2 alpha [ Rattus norvegicus (Norway rat) ]

    Gene ID: 500116, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Tra2aprovided by RGD
    Official Full Name
    transformer 2 alphaprovided by RGD
    Primary source
    RGD:1562563
    See related
    EnsemblRapid:ENSRNOG00000009156 AllianceGenome:RGD:1562563
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1562563
    Summary
    Predicted to enable RNA binding activity and identical protein binding activity. Predicted to be involved in mRNA splicing, via spliceosome and positive regulation of mRNA splicing, via spliceosome. Predicted to be located in nucleolus and nucleoplasm. Predicted to be part of spliceosomal complex. Orthologous to human TRA2A (transformer 2 alpha homolog). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 205.6), Spleen (RPKM 152.9) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Tra2a in Genome Data Viewer
    Location:
    4q24
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (79551699..79570621, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (78220838..78239737, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (78905380..78924203, complement)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene mitochondrial assembly of ribosomal large subunit 1 Neighboring gene insulin-like growth factor 2 mRNA binding protein 3 Neighboring gene gem (nuclear organelle) associated protein 7-like 1 Neighboring gene prothymosin alpha, pseudogene 6

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Human Tra2 proteins are sequence-specific activators of pre-mRNA splicing. Tacke R, et al. Cell, 1998 Apr 3. PMID 9546399
    2. Identification of evolutionarily conserved exons as regulated targets for the splicing activator tra2β in development. Grellscheid S, et al. PLoS Genet, 2011 Dec. PMID 22194695, Free PMC Article
    3. Androgens regulate the mammalian homologues of invertebrate sex determination genes tra-2 and fox-1. Lieberman AP, et al. Biochem Biophys Res Commun, 2001 Mar 30. PMID 11401487
    4. Cooperative actions of Tra2alpha with 9G8 and SRp30c in the RNA splicing of the gonadotropin-releasing hormone gene transcript. Park E, et al. J Biol Chem, 2006 Jan 6. PMID 16249178
    5. The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts. Baltz AG, et al. Mol Cell, 2012 Jun 8. PMID 22681889

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		  
    Process Evidence Code Pubs
    involved_in mRNA splicing, via spliceosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of mRNA splicing, via spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within positive regulation of mRNA splicing, via spliceosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of spliceosomal complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    transformer-2 protein homolog alpha
    Names
    transformer 2 alpha homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001126296.2 → NP_001119768.2  transformer-2 protein homolog alpha

      See identical proteins and their annotated locations for NP_001119768.2

      Status: VALIDATED

      Source sequence(s)
      BC161978, JAXUCZ010000004
      UniProtKB/TrEMBL
      B1WC25, F7ESB6
      Related
      ENSRNOP00000012325.9, ENSRNOT00000012325.9
      Conserved Domains (1) summary
      cd12363
      Location:116 → 195
      RRM_TRA2; RNA recognition motif (RRM) found in transformer-2 protein homolog TRA2-alpha, TRA2-beta and similar proteins

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      79551699..79570621 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006236465.5 → XP_006236527.1  transformer-2 protein homolog alpha isoform X4

      See identical proteins and their annotated locations for XP_006236527.1

      Conserved Domains (1) summary
      cd12363
      Location:116 → 195
      RRM_TRA2; RNA recognition motif (RRM) found in transformer-2 protein homolog TRA2-alpha, TRA2-beta and similar proteins

    2. XM_063286511.1 → XP_063142581.1  transformer-2 protein homolog alpha isoform X7

    3. XM_063286510.1 → XP_063142580.1  transformer-2 protein homolog alpha isoform X6

    4. XM_063286509.1 → XP_063142579.1  transformer-2 protein homolog alpha isoform X3

      UniProtKB/TrEMBL
      A0A8J8Y9E0
      Related
      ENSRNOP00000082266.2, ENSRNOT00000096480.2

    5. XM_039108127.2 → XP_038964055.1  transformer-2 protein homolog alpha isoform X1

      Conserved Domains (1) summary
      cd12363
      Location:116 → 195
      RRM_TRA2; RNA recognition motif (RRM) found in transformer-2 protein homolog TRA2-alpha, TRA2-beta and similar proteins

    6. XM_006236466.4 → XP_006236528.1  transformer-2 protein homolog alpha isoform X5

      Conserved Domains (1) summary
      cd12363
      Location:116 → 195
      RRM_TRA2; RNA recognition motif (RRM) found in transformer-2 protein homolog TRA2-alpha, TRA2-beta and similar proteins

    7. XM_006236464.4 → XP_006236526.1  transformer-2 protein homolog alpha isoform X2

      Conserved Domains (1) summary
      cd12363
      Location:116 → 195
      RRM_TRA2; RNA recognition motif (RRM) found in transformer-2 protein homolog TRA2-alpha, TRA2-beta and similar proteins

    8. XM_017592792.3 → XP_017448281.1  transformer-2 protein homolog alpha isoform X8

      Conserved Domains (1) summary
      cd12363
      Location:17 → 96
      RRM_TRA2; RNA recognition motif (RRM) found in transformer-2 protein homolog TRA2-alpha, TRA2-beta and similar proteins
    Nucleotide Protein Strain
    Heading Accession and Version

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