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    Icam5 intercellular adhesion molecule 5 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 313785, updated on 9-Dec-2024

    Summary

    Official Symbol
    Icam5provided by RGD
    Official Full Name
    intercellular adhesion molecule 5provided by RGD
    Primary source
    RGD:1305039
    See related
    EnsemblRapid:ENSRNOG00000020694 AllianceGenome:RGD:1305039
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable integrin binding activity. Predicted to be involved in cell adhesion and regulation of synapse assembly. Predicted to act upstream of or within phagocytosis. Predicted to be active in glutamatergic synapse; plasma membrane; and postsynapse. Orthologous to human ICAM5 (intercellular adhesion molecule 5). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 197.9) and Liver (RPKM 10.7) See more
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    Genomic context

    See Icam5 in Genome Data Viewer
    Location:
    8q13
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (27843563..27851767)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (19567390..19575588)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (22050222..22057209)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene intercellular adhesion molecule 1 Neighboring gene intercellular adhesion molecule 4, Landsteiner-Wiener blood group Neighboring gene zinc finger, GATA-like protein 1 Neighboring gene ferredoxin 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    Interactions

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables integrin binding  
    Process Evidence Code Pubs
    involved_in cell adhesion  
    involved_in cell-cell adhesion  
    acts_upstream_of_or_within phagocytosis  
    involved_in regulation of synapse assembly  
    Component Evidence Code Pubs
    is_active_in glutamatergic synapse  
    is_active_in plasma membrane  
    located_in plasma membrane  
    is_active_in postsynapse  

    General protein information

    Preferred Names
    intercellular adhesion molecule 5
    Names
    intercellular adhesion molecule 5, telencephalin

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001172079.1NP_001165550.1  intercellular adhesion molecule 5

      See identical proteins and their annotated locations for NP_001165550.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/TrEMBL
      A6JNN4, D4A435
      Related
      ENSRNOP00000028096.4, ENSRNOT00000028096.8
      Conserved Domains (7) summary
      cd00096
      Location:687738
      Ig; Immunoglobulin domain
      cd05755
      Location:120219
      Ig2_ICAM-1_like; Second immunoglobulin (Ig)-like domain of intercellular cell adhesion molecule-1 (ICAM-1, CD54) and similar proteins
      smart00408
      Location:759819
      IGc2; Immunoglobulin C-2 Type
      smart00410
      Location:756829
      IG_like; Immunoglobulin like
      pfam03921
      Location:32103
      ICAM_N; Intercellular adhesion molecule (ICAM), N-terminal domain
      pfam07679
      Location:572659
      I-set; Immunoglobulin I-set domain
      cl11960
      Location:323399
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      27843563..27851767
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. XR_005487805.2 RNA Sequence

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