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    Ptprr protein tyrosine phosphatase, receptor type, R [ Rattus norvegicus (Norway rat) ]

    Gene ID: 94202, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Ptprrprovided by RGD
    Official Full Name
    protein tyrosine phosphatase, receptor type, Rprovided by RGD
    Primary source
    RGD:620780
    See related
    EnsemblRapid:ENSRNOG00000004483 AllianceGenome:RGD:620780
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Pcptp1; R-PTP-R; PC12-PTP1
    Summary
    Predicted to enable protein kinase binding activity and protein tyrosine phosphatase activity. Involved in neuron differentiation. Predicted to be located in endomembrane system. Predicted to be active in cell junction; cytosol; and plasma membrane. Orthologous to human PTPRR (protein tyrosine phosphatase receptor type R). [provided by Alliance of Genome Resources, Dec 2024]
    Annotation information
    Note: There is an assembly problem in the Rnor_6.0 reference genome assembly, and therefore, annotation of this gene is split across NW_007905857.1 and NW_007905858.1 in NCBI's Rattus norvegicus Annotation Release 105. [17 Jun 2015]
    Expression
    Biased expression in Brain (RPKM 85.0), Heart (RPKM 53.3) and 5 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ptprr in Genome Data Viewer
    Location:
    7q22
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (53548611..53815632)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (51662595..51929605)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (59039717..59325925)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134479872 Neighboring gene uncharacterized LOC102551482 Neighboring gene uncharacterized LOC120093592 Neighboring gene TAF7-like RNA polymerase II, TATA box binding protein (TBP)-associated factor, pseudogene 1 Neighboring gene uncharacterized LOC120093594 Neighboring gene uncharacterized LOC120093595 Neighboring gene protein tyrosine phosphatase, receptor type, B Neighboring gene potassium calcium-activated channel subfamily M regulatory beta subunit 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Interaction between chicken protein tyrosine phosphatase 1 (CPTP1)-like rat protein phosphatase 1 (PTP1) and p60(v-src) in v-src-transformed Rat-1 fibroblasts. Jung EJ, et al. Exp Mol Med, 2002 Dec 31. PMID 12526090
    2. A neuronal protein tyrosine phosphatase induced by nerve growth factor. Sharma E, et al. J Biol Chem, 1995 Jan 6. PMID 7814416
    3. Cloning and expression of PCPTP1 encoding protein tyrosine phosphatase. Shiozuka K, et al. Gene, 1995 Sep 11. PMID 7557444
    4. A novel regulatory mechanism of MAP kinases activation and nuclear translocation mediated by PKA and the PTP-SL tyrosine phosphatase. Blanco-Aparicio C, et al. J Cell Biol, 1999 Dec 13. PMID 10601328, Free PMC Article
    5. Identification of PTPN23 as a novel regulator of cell invasion in mammary epithelial cells from a loss-of-function screen of the 'PTP-ome'. Lin G, et al. Genes Dev, 2011 Jul 1. PMID 21724833, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables histone H2AXY142 phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables non-membrane spanning protein tyrosine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein kinase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein kinase binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein tyrosine phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein tyrosine phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein tyrosine phosphatase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables protein tyrosine phosphatase activity, metal-dependent IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in ERBB2 signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ERBB2 signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in in utero embryonic development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in in utero embryonic development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in in utero embryonic development ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in negative regulation of ERK1 and ERK2 cascade IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of ERK1 and ERK2 cascade ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of epithelial cell migration IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of epithelial cell migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in nervous system development IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in neuron differentiation IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within protein dephosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    NOT involved_in regulation of homophilic cell adhesion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cell junction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cell junction IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cell junction ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endomembrane system IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    receptor-type tyrosine-protein phosphatase R
    Names
    protein-tyrosine phosphatase PCPTP1
    tyrosine phosphatase CBPTP
    NP_001106861.1
    NP_446046.2
    XP_063120425.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001113390.1 → NP_001106861.1  receptor-type tyrosine-protein phosphatase R isoform 2

      See identical proteins and their annotated locations for NP_001106861.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks two 5' exons but has an alternate 5' UTR exon, which results in a downstream AUG start codon, as compared to variant 1. The resulting isoform (2) has a shorter N-terminus, as compared to isoform 1.
      Source sequence(s)
      BC089186, D64050
      UniProtKB/TrEMBL
      A0A0G2JYG7, A6IGM2
      Related
      ENSRNOP00000070648.2, ENSRNOT00000085073.3
      Conserved Domains (2) summary
      smart00194
      Location:270 → 522
      PTPc; Protein tyrosine phosphatase, catalytic domain
      cd00047
      Location:295 → 522
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

    2. NM_053594.2 → NP_446046.2  receptor-type tyrosine-protein phosphatase R isoform 1 precursor

      See identical proteins and their annotated locations for NP_446046.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      BC089186, D38292, D64050
      UniProtKB/Swiss-Prot
      O08617, Q62695, Q63419
      UniProtKB/TrEMBL
      A6IGM0, G3V6L5
      Related
      ENSRNOP00000006401.3, ENSRNOT00000006401.6
      Conserved Domains (2) summary
      smart00194
      Location:391 → 643
      PTPc; Protein tyrosine phosphatase, catalytic domain
      cd00047
      Location:416 → 643
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      53548611..53815632
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063264355.1 → XP_063120425.1  receptor-type tyrosine-protein phosphatase R isoform X1

      UniProtKB/Swiss-Prot
      O08617, Q62695, Q63419
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O08617.2 GenPept UniProtKB/Swiss-Prot:O08617

    Gene LinkOut

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