Zp1 zona pellucida glycoprotein 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Zp1provided by RGD
Official Full Name: zona pellucida glycoprotein 1provided by RGD
Primary source: RGD:620604
See related: EnsemblRapid:ENSRNOG00000020907 AllianceGenome:RGD:620604
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: ZP1-202
Summary: Predicted to enable acrosin binding activity. Predicted to be a structural constituent of egg coat. Predicted to be involved in binding activity of sperm to zona pellucida and prevention of polyspermy. Predicted to be located in extracellular region and plasma membrane. Predicted to be active in collagen-containing extracellular matrix and egg coat. Orthologous to human ZP1 (zona pellucida glycoprotein 1). [provided by Alliance of Genome Resources, Jan 2025]
Expression: Biased expression in Uterus (RPKM 1.3), Testes (RPKM 0.5) and 6 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q43

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (216984343..216993882, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (207560881..207567261, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (226966366..226972746, complement)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Mutant Zp1 impedes incorporation of ZP3 and ZP4 in the zona pellucida, resulting in zona absence and female infertility in ratsdagger.
Title: Mutant Zp1 impedes incorporation of ZP3 and ZP4 in the zona pellucida, resulting in zona absence and female infertility in rats†.

Submit: New GeneRIF Correction

General gene information

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Markers

Zp1 (e-PCR), detects polymorphism
- UniSTS:525727

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables acrosin binding	IBA Inferred from Biological aspect of Ancestor more info
enables structural constituent of egg coat	IBA Inferred from Biological aspect of Ancestor more info
enables structural constituent of egg coat	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in binding of sperm to zona pellucida	IBA Inferred from Biological aspect of Ancestor more info
involved_in prevention of polyspermy	IBA Inferred from Biological aspect of Ancestor more info
involved_in single fertilization	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in collagen-containing extracellular matrix	IBA Inferred from Biological aspect of Ancestor more info
located_in collagen-containing extracellular matrix	IEA Inferred from Electronic Annotation more info
located_in collagen-containing extracellular matrix	ISO Inferred from Sequence Orthology more info
is_active_in egg coat	IBA Inferred from Biological aspect of Ancestor more info
located_in egg coat	IEA Inferred from Electronic Annotation more info
located_in egg coat	ISO Inferred from Sequence Orthology more info
located_in egg coat	ISS Inferred from Sequence or Structural Similarity more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: zona pellucida sperm-binding protein 1

Names: zona pellucida glycoprotein 1 (sperm receptor); zp-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_053509.1 → NP_445961.1 zona pellucida sperm-binding protein 1 precursor

Status: VALIDATED

Source sequence(s)

AB000928

UniProtKB/Swiss-Prot

O54766

UniProtKB/TrEMBL

A6I072, G3V8U5

Related

ENSRNOP00000028396.1, ENSRNOT00000028396.4

Conserved Domains (3) summary

smart00018
Location:224 → 266

PD; P or trefoil or TFF domain

smart00241
Location:269 → 539

ZP; Zona pellucida (ZP) domain

pfam00100
Location:402 → 537

Zona_pellucida; Zona pellucida-like domain