Arf6 ARF GTPase 6 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Arf6provided by RGD
Official Full Name: ARF GTPase 6provided by RGD
Primary source: RGD:621279
See related: EnsemblRapid:ENSRNOG00000070951 AllianceGenome:RGD:621279
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable several functions, including G protein activity; guanyl ribonucleotide binding activity; and thioesterase binding activity. Involved in several processes, including maintenance of postsynaptic density structure; negative regulation of dendrite development; and regulation of presynapse assembly. Located in early endosome; recycling endosome; and ruffle. Is active in glutamatergic synapse; postsynapse; and presynapse. Orthologous to human ARF6 (ARF GTPase 6). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: 6q24

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	6	NC_086024.1 (93589777..93590925)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	6	NC_051341.1 (87853742..87854890)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	6	NC_005105.4 (91697109..91698257)

Chromosome 6 - NC_086024.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The small GTPase ARF6 regulates GABAergic synapse development.
Title: The small GTPase ARF6 regulates GABAergic synapse development.
High glucose-induced cholesterol accumulation and cellular injury in podocytes may be related to the recycling disorder of ABCA1 caused by the downexpression of Arf6 in diabetic kidney disease.
Title: Small GTPase Arf6 regulates diabetes-induced cholesterol accumulation in podocytes.
both Arf6 activation through GluN2B-BRAG1 during early development and the transition from BRAG1- to BRAG2-dependent Arf6 signaling induced by the GluN2 subunit switch are critical for the development of mature glutamatergic synapses.
Title: Subunit-selective N-Methyl-d-aspartate (NMDA) Receptor Signaling through Brefeldin A-resistant Arf Guanine Nucleotide Exchange Factors BRAG1 and BRAG2 during Synapse Maturation.
The authors propose that Arf6 acts at the presynapse to define the fate of an endocytosed synaptic vesicle.
Title: Arf6 regulates the cycling and the readily releasable pool of synaptic vesicles at hippocampal synapse.
Ang II promotes activation of ARF6 to controls reactive oxygen species production by regulating Rac1 activation and Nox1 expression.
Title: The GTPase ARF6 Controls ROS Production to Mediate Angiotensin II-Induced Vascular Smooth Muscle Cell Proliferation.
Developmental upregulation of Arf6 enhanced retrograde transport in CNS axons.
Title: Exclusion of integrins from CNS axons is regulated by Arf6 activation and the AIS.
blocking neuronal activity in developing neurons using tetrodotoxin or enhancing the activity in mature neurons using picrotoxin or chemical long term potentiation reversed the effect of ARF6 on each stage
Title: ADP-ribosylation factor 6 (ARF6) bidirectionally regulates dendritic spine formation depending on neuronal maturation and activity.
Rab35/ACAP2 and cytohesin-2 antagonistically control oligodendrocyte differentiation and myelination through Arf6 regulation.
Title: Rab35, acting through ACAP2 switching off Arf6, negatively regulates oligodendrocyte differentiation and myelination.
hERG undergoes clathrin-independent endocytosis via a mechanism involving Arf6
Title: Endocytosis of HERG is clathrin-independent and involves arf6.
findings demonstrate an essential role of TBC1D24 in neuronal migration and maturation and highlight the physiological relevance of the ARF6-dependent membrane-trafficking pathway in brain development.
Title: TBC1D24 regulates neuronal migration and maturation through modulation of the ARF6-dependent pathway.

Submit: New GeneRIF Correction See all GeneRIFs (25)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

ARF6_719 (e-PCR)
- UniSTS:277010

AW496366 (e-PCR)
- UniSTS:180401

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables G protein activity	ISO Inferred from Sequence Orthology more info
enables G protein activity	ISS Inferred from Sequence or Structural Similarity more info
enables GDP binding	ISO Inferred from Sequence Orthology more info
enables GDP binding	ISS Inferred from Sequence or Structural Similarity more info
enables GTP binding	IBA Inferred from Biological aspect of Ancestor more info
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables GTP binding	ISO Inferred from Sequence Orthology more info
enables GTP binding	ISS Inferred from Sequence or Structural Similarity more info
enables GTPase activity	IEA Inferred from Electronic Annotation more info
enables signaling adaptor activity	ISO Inferred from Sequence Orthology more info
enables thioesterase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in actin cytoskeleton organization	TAS Traceable Author Statement more info	PubMed
involved_in cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in cellular response to nerve growth factor stimulus	IDA Inferred from Direct Assay more info	PubMed
involved_in cortical actin cytoskeleton organization	ISO Inferred from Sequence Orthology more info
involved_in endocytic recycling	IDA Inferred from Direct Assay more info	PubMed
involved_in endocytic recycling	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within erythrocyte apoptotic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within establishment of epithelial cell polarity	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within hepatocyte apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in intracellular protein transport	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within liver development	ISO Inferred from Sequence Orthology more info
involved_in maintenance of postsynaptic density structure	IDA Inferred from Direct Assay more info	PubMed
involved_in maintenance of postsynaptic density structure	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of dendrite development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of protein localization to cell surface	ISO Inferred from Sequence Orthology more info
involved_in nervous system development	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of actin filament polymerization	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of focal adhesion disassembly	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of keratinocyte migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of mitotic cytokinetic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of neuron projection development	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein localization to plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein secretion	ISO Inferred from Sequence Orthology more info
involved_in protein localization to cell surface	ISO Inferred from Sequence Orthology more info
involved_in protein localization to cleavage furrow	ISO Inferred from Sequence Orthology more info
involved_in protein localization to endosome	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein localization to endosome	ISO Inferred from Sequence Orthology more info
involved_in protein localization to endosome	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein localization to plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in regulation of Rac protein signal transduction	ISO Inferred from Sequence Orthology more info
involved_in regulation of dendritic spine development	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of dendritic spine development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of dendritic spine development	ISO Inferred from Sequence Orthology more info
involved_in regulation of filopodium assembly	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of neuron projection development	ISO Inferred from Sequence Orthology more info
involved_in regulation of presynapse assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of presynapse assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ruffle assembly	ISO Inferred from Sequence Orthology more info
involved_in synaptic vesicle endocytosis	IDA Inferred from Direct Assay more info	PubMed
involved_in synaptic vesicle endocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in vesicle-mediated transport	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in Flemming body	ISO Inferred from Sequence Orthology more info
located_in Flemming body	ISS Inferred from Sequence or Structural Similarity more info
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
located_in cell cortex	ISO Inferred from Sequence Orthology more info
is_active_in cleavage furrow	ISO Inferred from Sequence Orthology more info
located_in cleavage furrow	ISO Inferred from Sequence Orthology more info
located_in cleavage furrow	ISS Inferred from Sequence or Structural Similarity more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in cytosol	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
is_active_in cytosol	ISS Inferred from Sequence or Structural Similarity more info
located_in early endosome	IDA Inferred from Direct Assay more info	PubMed
located_in early endosome membrane	IEA Inferred from Electronic Annotation more info
is_active_in endocytic vesicle	IBA Inferred from Biological aspect of Ancestor more info
located_in endocytic vesicle	ISO Inferred from Sequence Orthology more info
located_in endocytic vesicle	ISS Inferred from Sequence or Structural Similarity more info
located_in endosome	ISO Inferred from Sequence Orthology more info
located_in exocytic vesicle	ISO Inferred from Sequence Orthology more info
located_in filopodium membrane	ISO Inferred from Sequence Orthology more info
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
located_in membrane	ISO Inferred from Sequence Orthology more info
is_active_in midbody	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in postsynapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in presynapse	IDA Inferred from Direct Assay more info	PubMed
located_in recycling endosome	IDA Inferred from Direct Assay more info	PubMed
is_active_in recycling endosome membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in recycling endosome membrane	ISO Inferred from Sequence Orthology more info
located_in recycling endosome membrane	ISS Inferred from Sequence or Structural Similarity more info
is_active_in ruffle	IBA Inferred from Biological aspect of Ancestor more info
located_in ruffle	IDA Inferred from Direct Assay more info	PubMed
located_in ruffle	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: ADP-ribosylation factor 6

NP_077066.1

EC 3.6.5.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.