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    Mybpc1 myosin binding protein C1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 362867, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Mybpc1provided by RGD
    Official Full Name
    myosin binding protein C1provided by RGD
    Primary source
    RGD:735102
    See related
    EnsemblRapid:ENSRNOG00000056493 AllianceGenome:RGD:735102
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable myosin binding activity. Predicted to be involved in cardiac muscle tissue development and sarcomere organization. Predicted to be located in intracellular membraneless organelle and myosin filament. Predicted to be active in M band. Human ortholog(s) of this gene implicated in congenital myopathy 16; distal arthrogryposis type 1B; and lethal congenital contracture syndrome 4. Orthologous to human MYBPC1 (myosin binding protein C1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward (RPKM 7577.9) See more
    Orthologs
    human mouse all
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    Genomic context

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    See Mybpc1 in Genome Data Viewer
    Location:
    7q13
    Exon count:
    33
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (24817770..24903681, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (22930350..23015981, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (29086159..29171909, complement)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene choline phosphotransferase 1 Neighboring gene synaptonemal complex protein 3 Neighboring gene uncharacterized LOC102554140 Neighboring gene uncharacterized LOC120093549 Neighboring gene Glyceraldehyde-3-phosphate dehydrogenase, pseudogene 33 Neighboring gene Spi-C transcription factor

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Characterization of pathogenic T cells and autoantibodies in C-protein-induced autoimmune polymyositis. Matsumoto Y, et al. J Neuroimmunol, 2007 Oct. PMID 17900708
    2. Myosin-binding protein C (MyBP-C) in cardiac muscle and contractility. Winegrad S. Adv Exp Med Biol, 2003. PMID 15098652
    3. Peripheral nervous system-specific genes identified by subtractive cDNA cloning. Akopian AN, et al. J Biol Chem, 1995 Sep 8. PMID 7673161
    4. Understanding the organisation and role of myosin binding protein C in normal striated muscle by comparison with MyBP-C knockout cardiac muscle. Luther PK, et al. J Mol Biol, 2008 Dec 5. PMID 18817784, Free PMC Article
    5. Obscurin interacts with a novel isoform of MyBP-C slow at the periphery of the sarcomeric M-band and regulates thick filament assembly. Ackermann MA, et al. Mol Biol Cell, 2009 Jun. PMID 19403693, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. A new ligand of obscurin at the M-band, MyBP-C slow variant-1 and suggest that their interaction contributes to the assembly of M-and A-bands, is identified.
      Title: Obscurin interacts with a novel isoform of MyBP-C slow at the periphery of the sarcomeric M-band and regulates thick filament assembly.
    2. The distribution of MyBP-C in the A-bands of cardiac and skeletal muscles and compare this to the A-band structure in cardiac muscle of MyBP-C-deficient mice, was investigated.
      Title: Understanding the organisation and role of myosin binding protein C in normal striated muscle by comparison with MyBP-C knockout cardiac muscle.
    3. These findings suggest that C-protein-induced EAM is formed by activation of C-protein-specific T cells along with antibodies against conformational epitopes in C-protein but that there are undetermined factors related to the disease progression.
      Title: Characterization of pathogenic T cells and autoantibodies in C-protein-induced autoimmune polymyositis.
    4. Myosin-binding protein C (MyBP-C) has roles in cardiac muscle and contractility [review]
      Title: Myosin-binding protein C (MyBP-C) in cardiac muscle and contractility.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables actin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables myosin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables myosin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables myosin binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables myosin binding TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cardiac muscle tissue development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in muscle contraction TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in sarcomere organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in M band IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in intracellular membraneless organelle IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in myosin filament IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    myosin-binding protein C, slow-type
    Names
    muscle C-protein
    myosin binding protein C, slow type
    slow MyBP-C

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001100758.3 → NP_001094228.3  myosin-binding protein C, slow-type

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000007
      UniProtKB/TrEMBL
      A0A0G2K7Q0, A0A8I5ZT65
      Related
      ENSRNOP00000074295.2, ENSRNOT00000079235.3
      Conserved Domains (6) summary
      cd00063
      Location:646 → 735
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:1073 → 1162
      I-set; Immunoglobulin I-set domain
      pfam18362
      Location:235 → 268
      THB; Tri-helix bundle domain
      cd00096
      Location:86 → 89
      Ig; Ig strand A [structural motif]
      cd05894
      Location:557 → 642
      Ig_C5_MyBP-C; C5 immunoglobulin (Ig) domain of cardiac myosin binding protein C (MyBP-C)
      cl11960
      Location:85 → 185
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      24817770..24903681 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063263768.1 → XP_063119838.1  myosin-binding protein C, slow-type isoform X16

      UniProtKB/TrEMBL
      A0A8I5ZTA0, A0A8I6ATF3
      Related
      ENSRNOP00000081963.2, ENSRNOT00000108545.2

    2. XM_008765256.4 → XP_008763478.1  myosin-binding protein C, slow-type isoform X12

      UniProtKB/TrEMBL
      A0A8I6ATF3
      Related
      ENSRNOP00000089644.2, ENSRNOT00000096740.2
      Conserved Domains (7) summary
      cd00096
      Location:1051 → 1116
      Ig; Immunoglobulin domain
      cd05894
      Location:518 → 603
      Ig_C5_MyBP-C; C5 immunoglobulin (Ig) domain of cardiac myosin binding protein C (MyBP-C)
      smart00410
      Location:521 → 603
      IG_like; Immunoglobulin like
      cd00063
      Location:607 → 696
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:1034 → 1123
      I-set; Immunoglobulin I-set domain
      pfam00047
      Location:51 → 135
      ig; Immunoglobulin domain
      cl11960
      Location:844 → 901
      Ig; Immunoglobulin domain

    3. XM_063263767.1 → XP_063119837.1  myosin-binding protein C, slow-type isoform X14

      UniProtKB/TrEMBL
      A0A8I6GG51
      Related
      ENSRNOP00000081596.2, ENSRNOT00000099906.2

    4. XM_063263764.1 → XP_063119834.1  myosin-binding protein C, slow-type isoform X7

      UniProtKB/TrEMBL
      A0A8I6GG51

    5. XM_063263766.1 → XP_063119836.1  myosin-binding protein C, slow-type isoform X10

      UniProtKB/TrEMBL
      A0A8I5ZWN5
      Related
      ENSRNOP00000083276.2, ENSRNOT00000113153.2

    6. XM_008765249.4 → XP_008763471.1  myosin-binding protein C, slow-type isoform X4

      UniProtKB/TrEMBL
      A0A8I5ZWN5
      Conserved Domains (7) summary
      cd00096
      Location:1076 → 1141
      Ig; Immunoglobulin domain
      cd05894
      Location:543 → 628
      Ig_C5_MyBP-C; C5 immunoglobulin (Ig) domain of cardiac myosin binding protein C (MyBP-C)
      smart00410
      Location:546 → 628
      IG_like; Immunoglobulin like
      cd00063
      Location:632 → 721
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:1059 → 1148
      I-set; Immunoglobulin I-set domain
      pfam00047
      Location:76 → 160
      ig; Immunoglobulin domain
      cl11960
      Location:869 → 926
      Ig; Immunoglobulin domain

    7. XM_008765257.4 → XP_008763479.1  myosin-binding protein C, slow-type isoform X13

      UniProtKB/TrEMBL
      A0A8I6ATF3
      Related
      ENSRNOP00000096490.1, ENSRNOT00000116177.2
      Conserved Domains (7) summary
      cd00096
      Location:1047 → 1112
      Ig; Immunoglobulin domain
      cd05894
      Location:532 → 617
      Ig_C5_MyBP-C; C5 immunoglobulin (Ig) domain of cardiac myosin binding protein C (MyBP-C)
      smart00410
      Location:535 → 617
      IG_like; Immunoglobulin like
      cd00063
      Location:621 → 710
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:1030 → 1119
      I-set; Immunoglobulin I-set domain
      pfam00047
      Location:65 → 149
      ig; Immunoglobulin domain
      cl11960
      Location:840 → 897
      Ig; Immunoglobulin domain

    8. XM_008765251.4 → XP_008763473.1  myosin-binding protein C, slow-type isoform X6

      UniProtKB/TrEMBL
      A0A8I6ATF3
      Conserved Domains (7) summary
      cd00096
      Location:1065 → 1130
      Ig; Immunoglobulin domain
      cd05894
      Location:532 → 617
      Ig_C5_MyBP-C; C5 immunoglobulin (Ig) domain of cardiac myosin binding protein C (MyBP-C)
      smart00410
      Location:535 → 617
      IG_like; Immunoglobulin like
      cd00063
      Location:621 → 710
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:1048 → 1137
      I-set; Immunoglobulin I-set domain
      pfam00047
      Location:65 → 149
      ig; Immunoglobulin domain
      cl11960
      Location:858 → 915
      Ig; Immunoglobulin domain

    9. XM_063263765.1 → XP_063119835.1  myosin-binding protein C, slow-type isoform X9

      UniProtKB/TrEMBL
      A0A8I6ATF3

    10. XM_063263763.1 → XP_063119833.1  myosin-binding protein C, slow-type isoform X2

      UniProtKB/TrEMBL
      A0A8I6ATF3

    11. XM_008765250.4 → XP_008763472.1  myosin-binding protein C, slow-type isoform X5

      UniProtKB/TrEMBL
      A0A8I5ZT65
      Conserved Domains (7) summary
      cd00096
      Location:1072 → 1137
      Ig; Immunoglobulin domain
      cd05894
      Location:557 → 642
      Ig_C5_MyBP-C; C5 immunoglobulin (Ig) domain of cardiac myosin binding protein C (MyBP-C)
      smart00410
      Location:560 → 642
      IG_like; Immunoglobulin like
      cd00063
      Location:646 → 735
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:1055 → 1144
      I-set; Immunoglobulin I-set domain
      pfam00047
      Location:90 → 174
      ig; Immunoglobulin domain
      cl11960
      Location:865 → 922
      Ig; Immunoglobulin domain

    12. XM_008765246.4 → XP_008763468.1  myosin-binding protein C, slow-type isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZT65
      Conserved Domains (7) summary
      cd00096
      Location:1090 → 1155
      Ig; Immunoglobulin domain
      cd05894
      Location:557 → 642
      Ig_C5_MyBP-C; C5 immunoglobulin (Ig) domain of cardiac myosin binding protein C (MyBP-C)
      smart00410
      Location:560 → 642
      IG_like; Immunoglobulin like
      cd00063
      Location:646 → 735
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:1073 → 1162
      I-set; Immunoglobulin I-set domain
      pfam00047
      Location:90 → 174
      ig; Immunoglobulin domain
      cl11960
      Location:883 → 940
      Ig; Immunoglobulin domain

    13. XM_008765258.4 → XP_008763480.1  myosin-binding protein C, slow-type isoform X15

      UniProtKB/TrEMBL
      A0A8I6AAS2
      Related
      ENSRNOP00000088357.2, ENSRNOT00000093952.2
      Conserved Domains (8) summary
      cd00096
      Location:1047 → 1112
      Ig; Immunoglobulin domain
      cd05894
      Location:532 → 617
      Ig_C5_MyBP-C; C5 immunoglobulin (Ig) domain of cardiac myosin binding protein C (MyBP-C)
      smart00410
      Location:535 → 617
      IG_like; Immunoglobulin like
      cd00063
      Location:621 → 710
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:1030 → 1119
      I-set; Immunoglobulin I-set domain
      pfam00047
      Location:65 → 149
      ig; Immunoglobulin domain
      pfam03755
      Location:150 → 249
      YicC_N; YicC-like family, N-terminal region
      cl11960
      Location:840 → 897
      Ig; Immunoglobulin domain

    14. XM_008765255.4 → XP_008763477.1  myosin-binding protein C, slow-type isoform X11

      UniProtKB/TrEMBL
      A0A8I6AAS2
      Conserved Domains (8) summary
      cd00096
      Location:1065 → 1130
      Ig; Immunoglobulin domain
      cd05894
      Location:532 → 617
      Ig_C5_MyBP-C; C5 immunoglobulin (Ig) domain of cardiac myosin binding protein C (MyBP-C)
      smart00410
      Location:535 → 617
      IG_like; Immunoglobulin like
      cd00063
      Location:621 → 710
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:1048 → 1137
      I-set; Immunoglobulin I-set domain
      pfam00047
      Location:65 → 149
      ig; Immunoglobulin domain
      pfam03755
      Location:150 → 249
      YicC_N; YicC-like family, N-terminal region
      cl11960
      Location:858 → 915
      Ig; Immunoglobulin domain

    15. XM_008765253.4 → XP_008763475.1  myosin-binding protein C, slow-type isoform X8

      UniProtKB/TrEMBL
      A0A8I5ZT65
      Conserved Domains (7) summary
      cd00096
      Location:1072 → 1137
      Ig; Immunoglobulin domain
      cd05894
      Location:557 → 642
      Ig_C5_MyBP-C; C5 immunoglobulin (Ig) domain of cardiac myosin binding protein C (MyBP-C)
      smart00410
      Location:560 → 642
      IG_like; Immunoglobulin like
      cd00063
      Location:646 → 735
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:1055 → 1144
      I-set; Immunoglobulin I-set domain
      pfam00047
      Location:90 → 174
      ig; Immunoglobulin domain
      cl11960
      Location:865 → 922
      Ig; Immunoglobulin domain

    16. XM_008765247.4 → XP_008763469.1  myosin-binding protein C, slow-type isoform X3

      UniProtKB/TrEMBL
      A0A8I5ZT65
      Related
      ENSRNOP00000069067.3, ENSRNOT00000079774.3
      Conserved Domains (7) summary
      cd00096
      Location:1090 → 1155
      Ig; Immunoglobulin domain
      cd05894
      Location:557 → 642
      Ig_C5_MyBP-C; C5 immunoglobulin (Ig) domain of cardiac myosin binding protein C (MyBP-C)
      smart00410
      Location:560 → 642
      IG_like; Immunoglobulin like
      cd00063
      Location:646 → 735
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:1073 → 1162
      I-set; Immunoglobulin I-set domain
      pfam00047
      Location:90 → 174
      ig; Immunoglobulin domain
      cl11960
      Location:883 → 940
      Ig; Immunoglobulin domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q63518.1 GenPept UniProtKB/Swiss-Prot:Q63518

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