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    Chrm5 cholinergic receptor, muscarinic 5 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 53949, updated on 9-Dec-2024

    Summary

    Official Symbol
    Chrm5provided by RGD
    Official Full Name
    cholinergic receptor, muscarinic 5provided by RGD
    Primary source
    RGD:620027
    See related
    EnsemblRapid:ENSRNOG00000006397 AllianceGenome:RGD:620027
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables G protein-coupled acetylcholine receptor activity. Involved in regulation of phosphatidylinositol dephosphorylation. Predicted to be located in postsynaptic membrane. Predicted to be active in dendrite; plasma membrane; and synapse. Orthologous to human CHRM5 (cholinergic receptor muscarinic 5). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 13.0), Spleen (RPKM 8.4) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Chrm5 in Genome Data Viewer
    Location:
    3q35
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (119739229..119791630, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (99284846..99337252, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (103966451..104018815, complement)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene 60S ribosomal protein L19-like Neighboring gene katanin regulatory subunit B1 like 1 Neighboring gene ER membrane protein complex subunit 7 Neighboring gene small nucleolar RNA SNORA11 Neighboring gene apoptosis and caspase activation inhibitor Neighboring gene proteasome subunit beta type-3-like Neighboring gene large ribosomal subunit protein eL30-like

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    General gene information

    Gene Ontology Provided by RGD

    Component Evidence Code Pubs
    is_active_in dendrite  
    is_active_in plasma membrane  
    located_in postsynaptic membrane  
    is_active_in synapse  

    General protein information

    Preferred Names
    muscarinic acetylcholine receptor M5

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_017362.5NP_059058.1  muscarinic acetylcholine receptor M5

      See identical proteins and their annotated locations for NP_059058.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/Swiss-Prot
      P08911
      UniProtKB/TrEMBL
      A6HP54
      Related
      ENSRNOP00000008387.4, ENSRNOT00000008387.8
      Conserved Domains (2) summary
      pfam00001
      Location:46255
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:39166
      7tm_4; Olfactory receptor

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      119739229..119791630 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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