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    Hsd17b10 hydroxysteroid (17-beta) dehydrogenase 10 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 63864, updated on 9-Dec-2024

    Summary

    Official Symbol
    Hsd17b10provided by RGD
    Official Full Name
    hydroxysteroid (17-beta) dehydrogenase 10provided by RGD
    Primary source
    RGD:69231
    See related
    EnsemblRapid:ENSRNOG00000003049 AllianceGenome:RGD:69231
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    ABAD; ERAB; MHBD; HSD10; Hadh2
    Summary
    Enables several functions, including amyloid-beta binding activity; nuclear estrogen receptor binding activity; and oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor. Involved in Leydig cell differentiation. Predicted to be located in endoplasmic reticulum and mitochondrial nucleoid. Predicted to be part of mitochondrial ribonuclease P complex and tRNA methyltransferase complex. Predicted to be active in mitochondrion. Human ortholog(s) of this gene implicated in pheochromocytoma and syndromic X-linked intellectual disability type 10. Orthologous to human HSD17B10 (hydroxysteroid 17-beta dehydrogenase 10). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Liver (RPKM 1394.2), Kidney (RPKM 1327.2) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Hsd17b10 in Genome Data Viewer
    Location:
    Xq13
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) X NC_086039.1 (24568551..24571012)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) X NC_051356.1 (21089142..21091603)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (21696796..21699241)

    Chromosome X - NC_086039.1Genomic Context describing neighboring genes Neighboring gene HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1 Neighboring gene microRNA let-7f-2 Neighboring gene microRNA 98 Neighboring gene RIB43A domain with coiled-coils 1 Neighboring gene structural maintenance of chromosomes 1A Neighboring gene large ribosomal subunit protein eL31-like

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by RGD

    Items 1 - 25 of 39
    Function Evidence Code Pubs
    enables 17-beta-hydroxysteroid dehydrogenase (NAD+) activity  
    enables 17-beta-hydroxysteroid dehydrogenase (NAD+) activity  
    enables 17-beta-hydroxysteroid dehydrogenase (NAD+) activity  
    enables 3-hydroxy-2-methylbutyryl-CoA dehydrogenase activity  
    enables 3-hydroxy-2-methylbutyryl-CoA dehydrogenase activity  
    enables 3-hydroxy-2-methylbutyryl-CoA dehydrogenase activity  
    enables 3-hydroxyacyl-CoA dehydrogenase activity  
    enables 3-hydroxyacyl-CoA dehydrogenase activity  
    enables 3-hydroxyacyl-CoA dehydrogenase activity  
    enables NAD binding PubMed 
    enables acetoacetyl-CoA reductase activity PubMed 
    enables amyloid-beta binding PubMed 
    enables androstan-3-alpha,17-beta-diol dehydrogenase activity  
    enables chenodeoxycholate 7-alpha-dehydrogenase (NAD+) activity  
    enables chenodeoxycholate 7-alpha-dehydrogenase (NAD+) activity  
    enables chenodeoxycholate 7-alpha-dehydrogenase (NAD+) activity  
    enables cholate 7-alpha-dehydrogenase activity  
    enables cholate 7-alpha-dehydrogenase activity  
    enables cholate 7-alpha-dehydrogenase activity  
    enables estradiol 17-beta-dehydrogenase [NAD(P)+] activity  
    enables estradiol 17-beta-dehydrogenase [NAD(P)+] activity PubMed 
    enables identical protein binding PubMed 
    enables isoursodeoxycholate 7-beta-dehydrogenase (NAD+) activity  
    enables isoursodeoxycholate 7-beta-dehydrogenase (NAD+) activity  
    enables isoursodeoxycholate 7-beta-dehydrogenase (NAD+) activity  
    enables nuclear estrogen receptor binding PubMed 
    enables oxidoreductase activity  
    enables steroid binding PubMed 
    enables tRNA binding  
    enables tRNA binding  
    enables tRNA binding  
    enables testosterone dehydrogenase (NAD+) activity  
    enables testosterone dehydrogenase (NAD+) activity  
    enables testosterone dehydrogenase (NAD+) activity  
    enables testosterone dehydrogenase [NAD(P)+] activity  
    enables testosterone dehydrogenase [NAD(P)+] activity  
    enables ursodeoxycholate 7-beta-dehydrogenase (NAD+) activity  
    enables ursodeoxycholate 7-beta-dehydrogenase (NAD+) activity  
    enables ursodeoxycholate 7-beta-dehydrogenase (NAD+) activity  
    Items 1 - 25 of 39
    Items 1 - 25 of 39
    Process Evidence Code Pubs
    involved_in C21-steroid hormone metabolic process  
    involved_in C21-steroid hormone metabolic process  
    involved_in C21-steroid hormone metabolic process  
    involved_in Leydig cell differentiation PubMed 
    involved_in androgen metabolic process  
    involved_in androgen metabolic process  
    involved_in androgen metabolic process  
    involved_in androgen metabolic process  
    involved_in bile acid biosynthetic process  
    involved_in bile acid biosynthetic process  
    involved_in bile acid biosynthetic process  
    involved_in brexanolone metabolic process  
    involved_in brexanolone metabolic process  
    involved_in brexanolone metabolic process  
    involved_in estrogen metabolic process  
    involved_in estrogen metabolic process  
    involved_in estrogen metabolic process  
    involved_in estrogen metabolic process  
    involved_in fatty acid beta-oxidation  
    involved_in fatty acid beta-oxidation  
    involved_in fatty acid beta-oxidation  
    involved_in fatty acid metabolic process  
    involved_in isoleucine catabolic process  
    involved_in isoleucine catabolic process  
    involved_in isoleucine catabolic process  
    involved_in male gonad development PubMed 
    involved_in mitochondrial tRNA 3'-end processing  
    involved_in mitochondrial tRNA 3'-end processing  
    involved_in mitochondrial tRNA 3'-end processing  
    involved_in mitochondrial tRNA 5'-end processing  
    involved_in mitochondrial tRNA 5'-end processing  
    involved_in mitochondrial tRNA 5'-end processing  
    involved_in mitochondrial tRNA methylation  
    involved_in mitochondrial tRNA methylation  
    involved_in mitochondrial tRNA methylation  
    involved_in mitochondrion organization  
    involved_in mitochondrion organization  
    involved_in protein homotetramerization  
    involved_in protein homotetramerization  
    Items 1 - 25 of 39
    Component Evidence Code Pubs
    located_in endoplasmic reticulum  
    located_in mitochondrial nucleoid  
    located_in mitochondrial nucleoid  
    located_in mitochondrial nucleoid  
    part_of mitochondrial ribonuclease P complex  
    part_of mitochondrial ribonuclease P complex  
    part_of mitochondrial ribonuclease P complex  
    is_active_in mitochondrion  
    located_in mitochondrion  
    located_in mitochondrion  
    part_of tRNA methyltransferase complex  
    part_of tRNA methyltransferase complex  

    General protein information

    Preferred Names
    3-hydroxyacyl-CoA dehydrogenase type-2
    Names
    17-beta-HSD 10
    17-beta-estradiol 17-dehydrogenase
    17-beta-hydroxysteroid dehydrogenase 10
    17I(2)-hydroxysteroid dehydrogenase type 10
    2-methyl-3-hydroxybutyryl-CoA dehydrogenase
    3-alpha-(17-beta)-hydroxysteroid dehydrogenase (NAD(+))
    3-hydroxy-2-methylbutyryl-CoA dehydrogenase
    3-hydroxyacyl-CoA dehydrogenase type II
    3alpha(or 20beta)-hydroxysteroid dehydrogenase
    7-alpha-hydroxysteroid dehydrogenase
    amyloid beta-peptide binding protein
    amyloid-beta peptide binding alcohol dehydrogenase
    endoplasmic reticulum-associated amyloid beta-peptide-binding protein
    hydroxyacyl-Coenzyme A dehydrogenase, type II
    mitochondrial RNase P protein 2
    mitochondrial ribonuclease P protein 2
    short chain L-3-hydroxyacyl-CoA dehydrogenase
    short chain dehydrogenase/reductase family 5C member 1
    short-chain type dehydrogenase/reductase XH98G2
    type II HADH
    NP_113870.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_031682.2NP_113870.1  3-hydroxyacyl-CoA dehydrogenase type-2

      See identical proteins and their annotated locations for NP_113870.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000021
      UniProtKB/Swiss-Prot
      O70351, Q9QYD4
      UniProtKB/TrEMBL
      B0BMW2, F1LNT4
      Related
      ENSRNOP00000043608.4, ENSRNOT00000043559.6
      Conserved Domains (2) summary
      cd05371
      Location:9261
      HSD10-like_SDR_c; 17hydroxysteroid dehydrogenase type 10 (HSD10)-like, classical (c) SDRs
      PRK05557
      Location:7260
      fabG; 3-ketoacyl-(acyl-carrier-protein) reductase; Validated

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086039.1 Reference GRCr8

      Range
      24568551..24571012
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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