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    Ppp1r14a protein phosphatase 1, regulatory (inhibitor) subunit 14A [ Rattus norvegicus (Norway rat) ]

    Gene ID: 114004, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ppp1r14aprovided by RGD
    Official Full Name
    protein phosphatase 1, regulatory (inhibitor) subunit 14Aprovided by RGD
    Primary source
    RGD:620536
    See related
    EnsemblRapid:ENSRNOG00000020676 AllianceGenome:RGD:620536
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Cpi17; CPI-17
    Summary
    Predicted to enable protein serine/threonine phosphatase inhibitor activity. Predicted to be involved in regulation of phosphorylation. Predicted to act upstream of or within cellular response to xenobiotic stimulus. Predicted to be located in cytoplasm. Orthologous to human PPP1R14A (protein phosphatase 1 regulatory inhibitor subunit 14A). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Lung (RPKM 467.7), Brain (RPKM 148.8) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ppp1r14a in Genome Data Viewer
    Location:
    1q21
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (93708269..93718218)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (84583127..84590743)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (87224683..87232842)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene MARCKS-related protein-like Neighboring gene similar to human chromosome 19 open reading frame 33 Neighboring gene Yip1 interacting factor homolog B, membrane trafficking protein Neighboring gene serine peptidase inhibitor, Kunitz type, 2 Neighboring gene signal-induced proliferation-associated 1 like 3 Neighboring gene double PHD fingers 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Prolonged bed rest impairs rapid CPI-17 phosphorylation and contraction in rat mesenteric resistance arteries to cause orthostatic hypotension. Kitazawa T, et al. Pflugers Arch, 2017 Dec. PMID 28717991
    2. Divergent kinase signaling mediates agonist-induced phosphorylation of phosphatase inhibitory proteins PHI-1 and CPI-17 in vascular smooth muscle cells. Pang H, et al. Am J Physiol Cell Physiol, 2006 Mar. PMID 16267107
    3. 17Beta-estradiol induces gastrointestinal motility disorder by decreasing CPI-17 phosphorylation via changes in rho-family G-protein Rnd expression in small intestine. Shimomura A, et al. J Vet Med Sci, 2009 Dec. PMID 20046026
    4. Reciprocal regulation controlling the expression of CPI-17, a specific inhibitor protein for the myosin light chain phosphatase in vascular smooth muscle cells. Kim JI, et al. Am J Physiol Cell Physiol, 2012 Jul 1. PMID 22538237, Free PMC Article
    5. Emodin inhibits tonic tension through suppressing PKCδ-mediated inhibition of myosin phosphatase in rat isolated thoracic aorta. Lim KM, et al. Br J Pharmacol, 2014 Sep. PMID 24909118, Free PMC Article

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Phosphorylated CPI-17 and MLC2 as Biomarkers of Coronary Artery Spasm-Induced Sudden Cardiac Death.
      Title: Phosphorylated CPI-17 and MLC2 as Biomarkers of Coronary Artery Spasm-Induced Sudden Cardiac Death.
    2. an impairment of the rapid CPI-17 signaling pathway mediating alpha1A-adrenoceptor activation is a cause of hypo-responsiveness of splanchnic resistance arteries, as an end organ of orthostatic blood pressure reflex, in the orthostatic hypotension model rats
      Title: Prolonged bed rest impairs rapid CPI-17 phosphorylation and contraction in rat mesenteric resistance arteries to cause orthostatic hypotension.
    3. Emodin attenuates tonic tension through the blockade of PKCdelta and CPI-17-mediated MLC-phosphatase inhibition.
      Title: Emodin inhibits tonic tension through suppressing PKCδ-mediated inhibition of myosin phosphatase in rat isolated thoracic aorta.
    4. Rac1 coordinates with RhoA to increase myosin light chain (MLC) phosphorylation by inactivation of CPI-17/MYPT1 phosphatase, which decreases MLC phosphatase activity thus promoting MLC phosphorylation and cell contraction
      Title: Rac1 regulates myosin II phosphorylation through regulation of myosin light chain phosphatase.
    5. Nuclear accumulation of CPI-17 is detected in proliferating vascular smooth muscle cell cultures and in neointima cells of a vascular injury model.
      Title: Nuclear localization of CPI-17, a protein phosphatase-1 inhibitor protein, affects histone H3 phosphorylation and corresponds to proliferation of cancer and smooth muscle cells.
    6. results suggest that myocardin-independent Sp1/Sp3 pathways regulate the CPI-17 transcription through multiple kinases, such as ERK1/2, p38, JNK, PKC, and ROCK in response to environmental changes
      Title: Reciprocal regulation controlling the expression of CPI-17, a specific inhibitor protein for the myosin light chain phosphatase in vascular smooth muscle cells.
    7. a novel signaling cascade that links RhoA-mediated calcium sensitivity to MEF2-dependent myocardin expression in VSMCs through a mechanism involving p38 MAPK, PP1alpha, and CPI-17.
      Title: A novel RhoA/ROCK-CPI-17-MEF2C signaling pathway regulates vascular smooth muscle cell gene expression.
    8. Data show that receptor stimulation increases Ca(2+) sensitivity of contractile elements through CPI-17 phosphorylation via the PKC/ROCK pathways and MYPT1 phosphorylation via the ROCK pathway in intestinal smooth muscle.
      Title: Synchronous phosphorylation of CPI-17 and MYPT1 is essential for inducing Ca(2+) sensitization in intestinal smooth muscle.
    9. PKCalpha and PKCepsilon may regulate vascular calcium sensitivity through change in protein expression and activity of CPI-17 in rats with hemorrhagic shock.
      Title: [The role of CPI-17 in vascular calcium sensitivity regulated by protein kinase Calpha and Cepsilon in rats with hemorrhagic shock].
    10. calcium-independent phospholipase A2beta has a role in high glucose-induced activation of RhoA, Rho kinase, and CPI-17 in cultured vascular smooth muscle cells and vascular smooth muscle hypercontractility in diabetic animals
      Title: Role of calcium-independent phospholipase A2beta in high glucose-induced activation of RhoA, Rho kinase, and CPI-17 in cultured vascular smooth muscle cells and vascular smooth muscle hypercontractility in diabetic animals.
    Submit: New GeneRIF Correction See all GeneRIFs (18)

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables protein phosphatase inhibitor activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables protein serine/threonine phosphatase inhibitor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine phosphatase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cellular response to xenobiotic stimulus ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    protein phosphatase 1 regulatory subunit 14A
    Names
    17 kDa PKC-potentiated inhibitory protein of PP1
    protein kinase C-potentiated inhibitor protein of 17 kDa

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_130403.2 → NP_569087.1  protein phosphatase 1 regulatory subunit 14A

      See identical proteins and their annotated locations for NP_569087.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/Swiss-Prot
      Q99MC0
      UniProtKB/TrEMBL
      A0A8L2QF19, A6J9Q5
      Conserved Domains (1) summary
      pfam05361
      Location:1 → 134
      PP1_inhibitor; PKC-activated protein phosphatase-1 inhibitor

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      93708269..93718218
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063261338.1 → XP_063117408.1  protein phosphatase 1 regulatory subunit 14A isoform X2

    2. XM_063261307.1 → XP_063117377.1  protein phosphatase 1 regulatory subunit 14A isoform X1

      UniProtKB/Swiss-Prot
      Q99MC0
      UniProtKB/TrEMBL
      A0A8L2QF19, A6J9Q5

    3. XM_017588644.2 → XP_017444133.1  protein phosphatase 1 regulatory subunit 14A isoform X1

      UniProtKB/Swiss-Prot
      Q99MC0
      UniProtKB/TrEMBL
      A0A8L2QF19, A6J9Q5
      Related
      ENSRNOP00000101169.1, ENSRNOT00000171120.1
      Conserved Domains (1) summary
      pfam05361
      Location:1 → 134
      PP1_inhibitor; PKC-activated protein phosphatase-1 inhibitor

    4. XM_063261331.1 → XP_063117401.1  protein phosphatase 1 regulatory subunit 14A isoform X1

      UniProtKB/Swiss-Prot
      Q99MC0
      UniProtKB/TrEMBL
      A0A8L2QF19, A6J9Q5

    5. XM_063261318.1 → XP_063117388.1  protein phosphatase 1 regulatory subunit 14A isoform X1

      UniProtKB/Swiss-Prot
      Q99MC0
      UniProtKB/TrEMBL
      A0A8L2QF19, A6J9Q5
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q99MC0.1 GenPept UniProtKB/Swiss-Prot:Q99MC0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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