Tspan2 tetraspanin 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Tspan2provided by RGD
Official Full Name: tetraspanin 2provided by RGD
Primary source: RGD:620982
See related: EnsemblRapid:ENSRNOG00000082472 AllianceGenome:RGD:620982
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Tspan-2
Summary: Predicted to act upstream of or within inflammatory response and nervous system development. Predicted to be located in myelin sheath and nucleoplasm. Predicted to be active in plasma membrane. Orthologous to human TSPAN2 (tetraspanin 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Lung (RPKM 362.4), Brain (RPKM 341.9) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 2q34

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	2	NC_086020.1 (192866212..192923489)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	2	NC_051337.1 (190177717..190234994)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	2	NC_005101.4 (205160405..205202766)

Chromosome 2 - NC_086020.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

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Markers

RH140772 (e-PCR)
- UniSTS:222838

RH128391 (e-PCR)
- UniSTS:211699

Gene Ontology Provided by RGD

Process	Evidence Code	Pubs
acts_upstream_of_or_within astrocyte development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within axon development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within inflammatory response	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within microglia development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within myelination	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within oligodendrocyte differentiation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in myelin sheath	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: tetraspanin-2

Names: tetraspan 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_022589.2 → NP_072111.1 tetraspanin-2

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000002

UniProtKB/Swiss-Prot

Q9JJW1

UniProtKB/TrEMBL

A6K3J1

Related

ENSRNOP00000106244.1, ENSRNOT00000168273.1

Conserved Domains (2) summary

cd03151
Location:110 → 186

CD81_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), CD81_like subfamily. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...

pfam00335
Location:10 → 214

Tetraspannin; Tetraspanin family