Bcl2a1 BCL2-related protein A1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Bcl2a1provided by RGD
Official Full Name: BCL2-related protein A1provided by RGD
Primary source: RGD:620621
See related: EnsemblRapid:ENSRNOG00000047606 AllianceGenome:RGD:620621
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Bcl2a1d
Summary: Enables BH domain binding activity. Involved in cerebral cortex development. Predicted to be located in cytoplasm. Predicted to be active in mitochondrial outer membrane. Orthologous to human BCL2A1 (BCL2 related protein A1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Spleen (RPKM 469.2), Thymus (RPKM 269.8) and 8 other tissues See more
Orthologs: human all
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Genomic context

Location:: 8q31

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	8	NC_086026.1 (98596806..98604890)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	8	NC_051343.1 (89716914..89724998)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	8	NC_005107.4 (96551424..96559527)

Chromosome 8 - NC_086026.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

the results of present study indicated that overexpression of ACC1 is significantly associated with the survival time of patients with liver cancer, and may provide insight into the association between ACC1 and cell proliferation in BRL 3A cells.
Title: ACC1 is overexpressed in liver cancers and contributes to the proliferation of human hepatoma Hep G2 cells and the rat liver cell line BRL 3A.
IL-1beta sensitizes pancreatic beta cells to apoptosis mainly via an imbalance in the ratio of the anti-apoptotic A1 and the pro-apoptotic BH3-only protein Bim.
Title: Endoplasmic reticulum stress sensitizes pancreatic beta cells to interleukin-1β-induced apoptosis via Bim/A1 imbalance.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables BH domain binding	IPI Inferred from Physical Interaction more info	PubMed
enables channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein-containing complex binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in cerebral cortex development	IEP Inferred from Expression Pattern more info	PubMed
involved_in extrinsic apoptotic signaling pathway in absence of ligand	IBA Inferred from Biological aspect of Ancestor more info
involved_in intrinsic apoptotic signaling pathway in response to DNA damage	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitochondrial fusion	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of apoptotic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in release of cytochrome c from mitochondria	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to cisplatin	IEP Inferred from Expression Pattern more info	PubMed
involved_in transmembrane transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in mitochondrial outer membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: bcl-2-related protein A1

Names: B-cell leukemia/lymphoma 2 related protein A1; B-cell leukemia/lymphoma 2 related protein A1d; BCL2-related protein A1d

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_133416.1 → NP_596907.1 bcl-2-related protein A1

Status: PROVISIONAL

Source sequence(s)

AF378332

UniProtKB/TrEMBL

A6I200, G3V977, Q925A9

Related

ENSRNOP00000038537.2, ENSRNOT00000039850.5

Conserved Domains (1) summary

smart00337
Location:37 → 140

BCL; BCL (B-Cell lymphoma); contains BH1, BH2 regions