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    Ereg epiregulin [ Rattus norvegicus (Norway rat) ]

    Gene ID: 59325, updated on 9-Dec-2024

    Summary

    Official Symbol
    Eregprovided by RGD
    Official Full Name
    epiregulinprovided by RGD
    Primary source
    RGD:620299
    See related
    EnsemblRapid:ENSRNOG00000002771 AllianceGenome:RGD:620299
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables growth factor activity. Involved in several processes, including luteinizing hormone signaling pathway; oogenesis; and positive regulation of mitotic nuclear division. Located in extracellular space. Human ortholog(s) of this gene implicated in extrapulmonary tuberculosis; pulmonary tuberculosis; and tuberculosis. Orthologous to human EREG (epiregulin). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward (RPKM 11.4) See more
    Orthologs
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    Genomic context

    See Ereg in Genome Data Viewer
    Location:
    14p22
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (17311485..17325260, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (17027287..17041062, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (18577620..18591395, complement)

    Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene betacellulin Neighboring gene amphiregulin Neighboring gene methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2-like Neighboring gene epithelial mitogen

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables epidermal growth factor receptor binding  
    enables epidermal growth factor receptor binding  
    enables epidermal growth factor receptor binding  
    enables growth factor activity  
    enables growth factor activity PubMed 
    enables growth factor activity  
    enables growth factor activity PubMed 
    enables receptor ligand activity  
    enables transmembrane receptor protein tyrosine kinase activator activity  
    Items 1 - 25 of 57
    Process Evidence Code Pubs
    involved_in ERBB2-EGFR signaling pathway  
    involved_in ERBB2-ERBB4 signaling pathway  
    involved_in ERBB4-ERBB4 signaling pathway  
    involved_in angiogenesis  
    involved_in cell-cell signaling  
    involved_in cell-cell signaling  
    involved_in cytokine-mediated signaling pathway  
    involved_in cytokine-mediated signaling pathway  
    involved_in epidermal growth factor receptor signaling pathway  
    involved_in epidermal growth factor receptor signaling pathway PubMed 
    involved_in epidermal growth factor receptor signaling pathway  
    involved_in epidermal growth factor receptor signaling pathway  
    involved_in female meiotic nuclear division PubMed 
    involved_in keratinocyte proliferation  
    involved_in keratinocyte proliferation  
    involved_in luteinizing hormone signaling pathway PubMed 
    involved_in mRNA transcription  
    involved_in mRNA transcription  
    involved_in negative regulation of DNA-templated transcription  
    involved_in negative regulation of DNA-templated transcription  
    involved_in negative regulation of cell population proliferation  
    involved_in negative regulation of cell population proliferation  
    involved_in negative regulation of smooth muscle cell differentiation  
    involved_in negative regulation of smooth muscle cell differentiation  
    involved_in oocyte maturation PubMed 
    involved_in ovarian cumulus expansion PubMed 
    involved_in ovulation PubMed 
    involved_in positive regulation of DNA replication PubMed 
    involved_in positive regulation of DNA replication  
    involved_in positive regulation of DNA replication  
    involved_in positive regulation of angiogenesis PubMed 
    involved_in positive regulation of cell division  
    involved_in positive regulation of cell population proliferation  
    involved_in positive regulation of cell population proliferation PubMed 
    involved_in positive regulation of cell population proliferation  
    involved_in positive regulation of cell population proliferation  
    involved_in positive regulation of cytokine production  
    involved_in positive regulation of cytokine production  
    involved_in positive regulation of fibroblast proliferation  
    involved_in positive regulation of fibroblast proliferation  
    involved_in positive regulation of innate immune response  
    involved_in positive regulation of innate immune response  
    involved_in positive regulation of interleukin-6 production  
    involved_in positive regulation of interleukin-6 production  
    involved_in positive regulation of mitotic nuclear division  
    involved_in positive regulation of mitotic nuclear division PubMed 
    involved_in positive regulation of mitotic nuclear division  
    involved_in positive regulation of mitotic nuclear division  
    involved_in positive regulation of phosphorylation  
    involved_in positive regulation of phosphorylation  
    involved_in positive regulation of protein kinase activity  
    involved_in positive regulation of protein kinase activity  
    involved_in positive regulation of smooth muscle cell proliferation PubMed 
    involved_in positive regulation of smooth muscle cell proliferation PubMed 
    involved_in primary follicle stage PubMed 
    involved_in response to peptide hormone PubMed 
    involved_in signal transduction  
    Items 1 - 25 of 57
    Component Evidence Code Pubs
    located_in extracellular region  
    is_active_in extracellular space  
    located_in extracellular space PubMed 
    is_active_in extracellular space  
    located_in extracellular space  
    located_in extracellular space  
    located_in membrane  
    located_in plasma membrane  

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_021689.1NP_067721.1  proepiregulin preproprotein

      See identical proteins and their annotated locations for NP_067721.1

      Status: VALIDATED

      Source sequence(s)
      AF074952
      UniProtKB/Swiss-Prot
      Q9Z0L5
      UniProtKB/TrEMBL
      A0A8I5ZT85
      Related
      ENSRNOP00000003716.2, ENSRNOT00000003716.5
      Conserved Domains (1) summary
      PHA03099
      Location:58146
      PHA03099; epidermal growth factor-like protein (EGF-like protein); Provisional

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086032.1 Reference GRCr8

      Range
      17311485..17325260 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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