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    Ret ret proto-oncogene [ Rattus norvegicus (Norway rat) ]

    Gene ID: 24716, updated on 9-Dec-2024

    Summary

    Official Symbol
    Retprovided by RGD
    Official Full Name
    ret proto-oncogeneprovided by RGD
    Primary source
    RGD:3556
    See related
    EnsemblRapid:ENSRNOG00000014751 AllianceGenome:RGD:3556
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable calcium ion binding activity and transmembrane receptor protein tyrosine kinase activity. Involved in several processes, including innervation; positive regulation of neuron maturation; and retina development in camera-type eye. Located in several cellular components, including dendrite; early endosome; and neuronal cell body. Biomarker of Parkinsonism; brain ischemia; and pheochromocytoma. Human ortholog(s) of this gene implicated in several diseases, including Hirschsprung's disease; familial medullary thyroid carcinoma; multiple endocrine neoplasia type 2A; multiple endocrine neoplasia type 2B; and pheochromocytoma. Orthologous to human RET (ret proto-oncogene). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 34.7), Lung (RPKM 33.7) and 7 other tissues See more
    Orthologs
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    Genomic context

    See Ret in Genome Data Viewer
    Location:
    4q42
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (152998344..153040556, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (151325969..151368176, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (150202170..150249196, complement)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene chondroitin sulfate N-acetylgalactosaminyltransferase 2 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene developmental pluripotency-associated 3, pseudogene 3 Neighboring gene RNA polymerase II, I and III subunit L, pseudogene 2 Neighboring gene 60S ribosomal protein L17 pseudogene Neighboring gene BMS1 ribosome biogenesis factor

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding  
    enables GPI-linked ephrin receptor activity  
    enables boss receptor activity  
    enables brain-derived neurotrophic factor receptor activity  
    enables calcium ion binding  
    enables epidermal growth factor receptor activity  
    enables fibroblast growth factor receptor activity  
    enables hepatocyte growth factor receptor activity  
    enables histone H2AXY142 kinase activity  
    enables histone H3Y41 kinase activity  
    enables insulin receptor activity  
    enables insulin-like growth factor receptor activity  
    enables macrophage colony-stimulating factor receptor activity  
    enables placental growth factor receptor activity  
    enables platelet-derived growth factor alpha-receptor activity  
    enables platelet-derived growth factor beta-receptor activity  
    enables protein tyrosine kinase collagen receptor activity  
    enables stem cell factor receptor activity  
    enables transmembrane receptor protein tyrosine kinase activity  
    enables transmembrane receptor protein tyrosine kinase activity  
    enables transmembrane receptor protein tyrosine kinase activity  
    enables transmembrane-ephrin receptor activity  
    enables vascular endothelial growth factor receptor activity  
    Items 1 - 25 of 56
    Process Evidence Code Pubs
    involved_in GDF15-GFRAL signaling pathway  
    involved_in Kit signaling pathway  
    acts_upstream_of_or_within MAPK cascade  
    involved_in Peyer's patch morphogenesis  
    involved_in brain-derived neurotrophic factor receptor signaling pathway  
    involved_in cell surface receptor protein tyrosine kinase signaling pathway  
    acts_upstream_of_or_within cell surface receptor protein tyrosine kinase signaling pathway  
    involved_in cellular response to retinoic acid  
    involved_in chromatin remodeling  
    involved_in collagen-activated tyrosine kinase receptor signaling pathway  
    acts_upstream_of_or_within embryonic epithelial tube formation  
    acts_upstream_of_or_within enteric nervous system development  
    involved_in ephrin receptor signaling pathway  
    involved_in epidermal growth factor receptor signaling pathway  
    involved_in fibroblast growth factor receptor signaling pathway  
    involved_in glial cell-derived neurotrophic factor receptor signaling pathway  
    involved_in glial cell-derived neurotrophic factor receptor signaling pathway  
    involved_in hepatocyte growth factor receptor signaling pathway  
    involved_in homophilic cell adhesion via plasma membrane adhesion molecules  
    involved_in innervation PubMed 
    involved_in insulin receptor signaling pathway  
    involved_in insulin-like growth factor receptor signaling pathway  
    involved_in macrophage colony-stimulating factor signaling pathway  
    involved_in membrane protein proteolysis  
    involved_in multicellular organism development  
    acts_upstream_of_or_within nervous system development  
    acts_upstream_of_or_within neural crest cell migration  
    involved_in neuron cell-cell adhesion  
    acts_upstream_of_or_within neuron differentiation  
    acts_upstream_of_or_within neuron maturation  
    involved_in platelet-derived growth factor receptor-alpha signaling pathway  
    involved_in platelet-derived growth factor receptor-beta signaling pathway  
    involved_in positive regulation of DNA-templated transcription  
    involved_in positive regulation of MAPK cascade  
    involved_in positive regulation of MAPK cascade  
    involved_in positive regulation of cell adhesion mediated by integrin  
    involved_in positive regulation of cell migration  
    acts_upstream_of_or_within positive regulation of cell size  
    involved_in positive regulation of cysteine-type endopeptidase activity  
    involved_in positive regulation of extrinsic apoptotic signaling pathway in absence of ligand  
    acts_upstream_of_or_within positive regulation of gene expression  
    involved_in positive regulation of metanephric glomerulus development  
    involved_in positive regulation of neuron maturation PubMed 
    involved_in positive regulation of neuron projection development  
    acts_upstream_of_or_within positive regulation of peptidyl-serine phosphorylation of STAT protein  
    involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  
    involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  
    acts_upstream_of_or_within regulation of axonogenesis  
    involved_in regulation of cell adhesion  
    involved_in response to pain  
    involved_in response to xenobiotic stimulus PubMed 
    involved_in retina development in camera-type eye PubMed 
    acts_upstream_of_or_within ureter maturation  
    acts_upstream_of_or_within ureteric bud development  
    involved_in vascular endothelial growth factor receptor-1 signaling pathway  
    involved_in vascular endothelial growth factor signaling pathway  
    Items 1 - 25 of 56
    Component Evidence Code Pubs
    is_active_in axon  
    located_in axon PubMed 
    located_in dendrite PubMed 
    located_in early endosome PubMed 
    located_in endosome membrane  
    located_in neuronal cell body PubMed 
    is_active_in plasma membrane  
    is_active_in plasma membrane  
    located_in plasma membrane  
    located_in plasma membrane  
    part_of plasma membrane protein complex  
    part_of receptor complex  
    part_of receptor complex  

    General protein information

    Preferred Names
    proto-oncogene tyrosine-protein kinase receptor Ret
    Names
    Ret gene for receptor tyrosin
    Ret proto-oncogene (multiple endocrine neoplasia MEN2A MEN2B and medullary thyroid carcinoma 1 Hirschsprung disease)
    receptor tyrosine kinase
    NP_001103569.1
    NP_036775.2
    XP_063141631.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001110099.1NP_001103569.1  proto-oncogene tyrosine-protein kinase receptor Ret isoform b precursor

      See identical proteins and their annotated locations for NP_001103569.1

      Status: PROVISIONAL

      Description
      Transcript Variant: This variant (2) differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (b) has a shorter and unique C-terminus compared to isoform a.
      Source sequence(s)
      JAXUCZ010000004
      UniProtKB/TrEMBL
      A6IL58
      Conserved Domains (3) summary
      cd05045
      Location:7241013
      PTKc_RET; Catalytic domain of the Protein Tyrosine Kinase, REarranged during Transfection protein
      pfam00028
      Location:173248
      Cadherin; Cadherin domain
      pfam07714
      Location:7251006
      Pkinase_Tyr; Protein tyrosine kinase
    2. NM_012643.2NP_036775.2  proto-oncogene tyrosine-protein kinase receptor Ret isoform a precursor

      See identical proteins and their annotated locations for NP_036775.2

      Status: PROVISIONAL

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
      Source sequence(s)
      JAXUCZ010000004
      UniProtKB/Swiss-Prot
      G3V9H8, Q9EPA1, Q9EPC3
      Related
      ENSRNOP00000047793.3, ENSRNOT00000047685.6
      Conserved Domains (3) summary
      cd05045
      Location:7241013
      PTKc_RET; Catalytic domain of the Protein Tyrosine Kinase, REarranged during Transfection protein
      pfam00028
      Location:173248
      Cadherin; Cadherin domain
      pfam07714
      Location:7251006
      Pkinase_Tyr; Protein tyrosine kinase

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      152998344..153040556 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063285561.1XP_063141631.1  proto-oncogene tyrosine-protein kinase receptor Ret isoform X1

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