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    Cacna1s calcium voltage-gated channel subunit alpha1 S [ Rattus norvegicus (Norway rat) ]

    Gene ID: 682930, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Cacna1sprovided by RGD
    Official Full Name
    calcium voltage-gated channel subunit alpha1 Sprovided by RGD
    Primary source
    RGD:70983
    See related
    EnsemblRapid:ENSRNOG00000046231 AllianceGenome:RGD:70983
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Cchl1a3; RGD1565743
    Summary
    Enables high voltage-gated calcium channel activity. Involved in calcium ion transport and response to caloric restriction. Located in dendritic spine head and sarcolemma. Part of voltage-gated calcium channel complex. Human ortholog(s) of this gene implicated in congenital myopathy 18; hypokalemic periodic paralysis; and malignant hyperthermia. Orthologous to human CACNA1S (calcium voltage-gated channel subunit alpha1 S). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward (RPKM 1096.3) See more
    Orthologs
    human mouse all
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    Genomic context

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    See Cacna1s in Genome Data Viewer
    Location:
    13q13
    Exon count:
    44
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (50045668..50115903)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (47493949..47564194)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (52889570..52964558)

    Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene transmembrane protein 9 Neighboring gene achaete-scute family bHLH transcription factor 5 Neighboring gene uncharacterized LOC134481564 Neighboring gene kinesin family member 21B Neighboring gene maestro heat-like repeat family member 3 Neighboring gene mitochondrial ribosomal protein L42 like 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Cyclic AMP-dependent phosphorylation of two size forms of alpha 1 subunits of L-type calcium channels in rat skeletal muscle cells. Lai Y, et al. J Biol Chem, 1990 Dec 5. PMID 2174428
    2. Voltage-gated Ca2+ channel mRNAs and T-type Ca2+ currents in rat gonadotropin-releasing hormone neurons. Tanaka N, et al. J Physiol Sci, 2010 May. PMID 20101487, Free PMC Article
    3. Effects of the muscular dysgenesis gene on developmental stability in the mouse mandible. Atchley WR, et al. J Craniofac Genet Dev Biol, 1984. PMID 6501560
    4. Gating of the L-type Ca channel in human skeletal myotubes: an activation defect caused by the hypokalemic periodic paralysis mutation R528H. Morrill JA, et al. J Neurosci, 1998 Dec 15. PMID 9852570, Free PMC Article
    5. Caloric restriction prevents age-related decline in skeletal muscle dihydropyridine receptor and ryanodine receptor expression. Renganathan M, et al. FEBS Lett, 1998 Sep 4. PMID 9742952

    See all (48) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Septic diaphragm contractility and expression of Cacna1s and RyR1 are significantly decreased in a sepsis model compared with controls.
      Title: Decreased intracellular [Ca(2+) ] coincides with reduced expression of Dhprα1s, RyR1, and diaphragmatic dysfunction in a rat model of sepsis.
    2. The expression levels of dihydropyridine alpha1s and RyR1 receptors (the isoforms of skeletal muscles) are significantly lower in septic rats than in control rats.
      Title: Reduced DHPRα1S and RyR1 expression levels are associated with diaphragm contractile dysfunction during sepsis.
    3. sequences in the IQ motifs of CaV1.1 and CaV1.2 strongly impact calmodulin binding and calcium-dependent inactivation
      Title: Sequence differences in the IQ motifs of CaV1.1 and CaV1.2 strongly impact calmodulin binding and calcium-dependent inactivation.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables calmodulin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables high voltage-gated calcium channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables high voltage-gated calcium channel activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables high voltage-gated calcium channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables high voltage-gated calcium channel activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular function activator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables small molecule binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables voltage-gated calcium channel activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables voltage-gated calcium channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables voltage-gated calcium channel activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in calcium ion import across plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in calcium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in calcium ion transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within calcium ion transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in calcium ion transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular response to caffeine ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in endoplasmic reticulum organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within endoplasmic reticulum organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in extraocular skeletal muscle development IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within extraocular skeletal muscle development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within muscle cell development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within muscle contraction ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in muscle contraction ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in muscle contraction ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in myoblast fusion IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within myoblast fusion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in neuromuscular junction development IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within neuromuscular junction development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in ossification NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in release of sequestered calcium ion into cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in release of sequestered calcium ion into cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in release of sequestered calcium ion into cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in response to caloric restriction IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in skeletal muscle adaptation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within skeletal muscle adaptation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in skeletal muscle fiber development IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within skeletal muscle fiber development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within skeletal muscle tissue development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in skeletal system development IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within skeletal system development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in striated muscle contraction IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within striated muscle contraction ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in I band IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in I band ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of L-type voltage-gated calcium channel complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in T-tubule IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in T-tubule ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in T-tubule ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in dendritic spine head IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in sarcolemma IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in sarcoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in sarcoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in somatodendritic compartment IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of voltage-gated calcium channel complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of voltage-gated calcium channel complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of voltage-gated calcium channel complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of voltage-gated calcium channel complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    voltage-dependent L-type calcium channel subunit alpha-1S
    Names
    ROB1
    calcium channel, voltage-dependent, L type, alpha 1S subunit
    voltage-gated calcium channel subunit alpha Cav1.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_053873.1 → NP_446325.1  voltage-dependent L-type calcium channel subunit alpha-1S

      See identical proteins and their annotated locations for NP_446325.1

      Status: PROVISIONAL

      Source sequence(s)
      AB374360
      UniProtKB/Swiss-Prot
      B3XZL8, P70484, Q01553, Q02485, Q62817
      UniProtKB/TrEMBL
      M0RCE9
      Related
      ENSRNOP00000067264.3, ENSRNOT00000074366.4
      Conserved Domains (4) summary
      pfam00520
      Location:1117 → 1392
      Ion_trans; Ion transport protein
      pfam08763
      Location:1465 → 1536
      Ca_chan_IQ; Voltage gated calcium channel IQ domain
      pfam16885
      Location:1558 → 1838
      CAC1F_C; Voltage-gated calcium channel subunit alpha, C-term
      pfam16905
      Location:1393 → 1463
      GPHH; Voltage-dependent L-type calcium channel, IQ-associated

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086031.1 Reference GRCr8

      Range
      50045668..50115903
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q02485.2 GenPept UniProtKB/Swiss-Prot:Q02485

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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