Gnpda1 glucosamine-6-phosphate deaminase 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Gnpda1provided by RGD
Official Full Name: glucosamine-6-phosphate deaminase 1provided by RGD
Primary source: RGD:1585624
See related: EnsemblRapid:ENSRNOG00000047213 AllianceGenome:RGD:1585624
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable glucosamine-6-phosphate deaminase activity and identical protein binding activity. Predicted to be involved in several processes, including N-acetylneuraminate catabolic process; UDP-N-acetylglucosamine biosynthetic process; and glucosamine-containing compound catabolic process. Predicted to be active in cytoplasm. Orthologous to human GNPDA1 (glucosamine-6-phosphate deaminase 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Kidney (RPKM 481.8), Adrenal (RPKM 213.5) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 18p11

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	18	NC_086036.1 (30416599..30428630, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	18	NC_051353.1 (30165435..30177462, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	18	NC_005117.4 (31479117..31489154, complement)

Chromosome 18 - NC_086036.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

BF390374 (e-PCR)
- UniSTS:249451

D18Got31 (e-PCR)
- UniSTS:113106

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables glucosamine-6-phosphate deaminase activity	IBA Inferred from Biological aspect of Ancestor more info
enables glucosamine-6-phosphate deaminase activity	ISO Inferred from Sequence Orthology more info
enables identical protein binding	IBA Inferred from Biological aspect of Ancestor more info
enables isomerase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in N-acetylglucosamine catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in N-acetylneuraminate catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in UDP-N-acetylglucosamine biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in UDP-N-acetylglucosamine biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in carbohydrate metabolic process	IEA Inferred from Electronic Annotation more info
involved_in generation of precursor metabolites and energy	ISO Inferred from Sequence Orthology more info
involved_in glucosamine catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in glucosamine catabolic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: glucosamine-6-phosphate isomerase 1

Names: oscillin

NP_001128467.1

EC 3.5.99.6

XP_063133660.1

EC 3.5.99.6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001134995.1 → NP_001128467.1 glucosamine-6-phosphate isomerase 1

See identical proteins and their annotated locations for NP_001128467.1

Status: PROVISIONAL

Source sequence(s)

CH473974

UniProtKB/TrEMBL

A0A9K3Y6P1, B5DFC6, M0RCH5

Related

ENSRNOP00000067293.3, ENSRNOT00000071560.4

Conserved Domains (1) summary

cl00339
Location:1 → 253

SugarP_isomerase; Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose ...