Cd22 CD22 molecule [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Cd22provided by RGD
Official Full Name: CD22 moleculeprovided by RGD
Primary source: RGD:1311610
See related: EnsemblRapid:ENSRNOG00000024000 AllianceGenome:RGD:1311610
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable CD4 receptor binding activity; protein phosphatase binding activity; and sialic acid binding activity. Predicted to be involved in several processes, including negative regulation of immunoglobulin production; negative regulation of signal transduction; and regulation of B cell proliferation. Predicted to be located in cell surface and neuronal cell body membrane. Predicted to be active in early endosome; external side of plasma membrane; and recycling endosome. Human ortholog(s) of this gene implicated in diffuse large B-cell lymphoma. Orthologous to human CD22 (CD22 molecule). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Spleen (RPKM 371.2), Thymus (RPKM 52.3) and 1 other tissue See more
Orthologs: human mouse all
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Genomic context

Location:: 1q21

Exon count:: 22

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (95243785..95270430, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (86116376..86132782, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (89313475..89329902, complement)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

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Markers

AI178268 (e-PCR)
- UniSTS:250409

Cd22 (e-PCR), detects polymorphism
- UniSTS:141275

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables CD4 receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables CD4 receptor binding	ISO Inferred from Sequence Orthology more info
enables carbohydrate binding	IEA Inferred from Electronic Annotation more info
enables protein phosphatase binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein phosphatase binding	ISO Inferred from Sequence Orthology more info
enables sialic acid binding	IBA Inferred from Biological aspect of Ancestor more info
enables sialic acid binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in B cell activation	IBA Inferred from Biological aspect of Ancestor more info
involved_in B cell activation	ISO Inferred from Sequence Orthology more info
involved_in cell adhesion	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of B cell receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of B cell receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of calcium-mediated signaling	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of immunoglobulin production	ISO Inferred from Sequence Orthology more info
involved_in regulation of B cell proliferation	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of B cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in regulation of endocytosis	ISO Inferred from Sequence Orthology more info
involved_in regulation of immune response	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cell surface	ISO Inferred from Sequence Orthology more info
is_active_in early endosome	IBA Inferred from Biological aspect of Ancestor more info
located_in early endosome	ISO Inferred from Sequence Orthology more info
is_active_in external side of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in external side of plasma membrane	ISO Inferred from Sequence Orthology more info
located_in neuronal cell body membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in recycling endosome	IBA Inferred from Biological aspect of Ancestor more info
located_in recycling endosome	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: B-cell receptor CD22

Names: CD22 antigen

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001107503.1 → NP_001100973.1 B-cell receptor CD22 precursor

See identical proteins and their annotated locations for NP_001100973.1

Status: PROVISIONAL

Source sequence(s)

CH473979

UniProtKB/TrEMBL

A6JA30, D3ZD88

Related

ENSRNOP00000031661.4, ENSRNOT00000033155.7

Conserved Domains (5) summary

smart00408
Location:350 → 408

IGc2; Immunoglobulin C-2 Type

smart00409
Location:610 → 682

IG; Immunoglobulin

cd00096
Location:24 → 28

Ig; Ig strand A [structural motif]

cd20938
Location:147 → 242

IgC1_CD22_d2; Second immunoglobulin domain of Cluster of Differentiation (CD) 22; member of the Constant 1 (C1)-set of IgSF domains

cl11960
Location:24 → 143

Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

95243785..95270430 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063261594.1 → XP_063117664.1 B-cell receptor CD22 isoform X1
XM_006228828.5 → XP_006228890.1 B-cell receptor CD22 isoform X1

See identical proteins and their annotated locations for XP_006228890.1

UniProtKB/TrEMBL

A6JA30, D3ZD88

Conserved Domains (5) summary

smart00408
Location:350 → 408

IGc2; Immunoglobulin C-2 Type

smart00409
Location:610 → 682

IG; Immunoglobulin

cd00096
Location:24 → 28

Ig; Ig strand A [structural motif]

cd20938
Location:147 → 242

IgC1_CD22_d2; Second immunoglobulin domain of Cluster of Differentiation (CD) 22; member of the Constant 1 (C1)-set of IgSF domains

cl11960
Location:24 → 143

Ig; Immunoglobulin domain
XM_039111593.2 → XP_038967521.1 B-cell receptor CD22 isoform X1

UniProtKB/TrEMBL

A6JA30, D3ZD88

Conserved Domains (5) summary

smart00408
Location:350 → 408

IGc2; Immunoglobulin C-2 Type

smart00409
Location:610 → 682

IG; Immunoglobulin

cd00096
Location:24 → 28

Ig; Ig strand A [structural motif]

cd20938
Location:147 → 242

IgC1_CD22_d2; Second immunoglobulin domain of Cluster of Differentiation (CD) 22; member of the Constant 1 (C1)-set of IgSF domains

cl11960
Location:24 → 143

Ig; Immunoglobulin domain
XM_008759154.4 → XP_008757376.1 B-cell receptor CD22 isoform X2

Related

ENSRNOP00000106657.1, ENSRNOT00000133006.1

Conserved Domains (6) summary

smart00408
Location:350 → 408

IGc2; Immunoglobulin C-2 Type

smart00410
Location:523 → 594

IG_like; Immunoglobulin like

pfam07679
Location:246 → 332

I-set; Immunoglobulin I-set domain

pfam13895
Location:248 → 332

Ig_2; Immunoglobulin domain

pfam13927
Location:605 → 668

Ig_3; Immunoglobulin domain

cl11960
Location:149 → 228

Ig; Immunoglobulin domain
XM_008759153.4 → XP_008757375.1 B-cell receptor CD22 isoform X1

See identical proteins and their annotated locations for XP_008757375.1

UniProtKB/TrEMBL

A6JA30, D3ZD88

Conserved Domains (5) summary

smart00408
Location:350 → 408

IGc2; Immunoglobulin C-2 Type

smart00409
Location:610 → 682

IG; Immunoglobulin

cd00096
Location:24 → 28

Ig; Ig strand A [structural motif]

cd20938
Location:147 → 242

IgC1_CD22_d2; Second immunoglobulin domain of Cluster of Differentiation (CD) 22; member of the Constant 1 (C1)-set of IgSF domains

cl11960
Location:24 → 143

Ig; Immunoglobulin domain
XM_063261598.1 → XP_063117668.1 B-cell receptor CD22 isoform X3
XM_039111597.2 → XP_038967525.1 B-cell receptor CD22 isoform X4

Conserved Domains (5) summary

smart00408
Location:350 → 408

IGc2; Immunoglobulin C-2 Type

smart00410
Location:610 → 682

IG_like; Immunoglobulin like

cd00096
Location:24 → 28

Ig; Ig strand A [structural motif]

cd20938
Location:147 → 242

IgC1_CD22_d2; Second immunoglobulin domain of Cluster of Differentiation (CD) 22; member of the Constant 1 (C1)-set of IgSF domains

cl11960
Location:24 → 143

Ig; Immunoglobulin domain