Trim14 tripartite motif-containing 14 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Trim14provided by RGD
Official Full Name: tripartite motif-containing 14provided by RGD
Primary source: RGD:1311514
See related: EnsemblRapid:ENSRNOG00000008922 AllianceGenome:RGD:1311514
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable transcription coactivator activity and ubiquitin protein ligase activity. Predicted to be involved in several processes, including innate immune response; negative regulation of viral transcription; and positive regulation of NF-kappaB transcription factor activity. Predicted to be active in cytoplasm. Orthologous to human TRIM14 (tripartite motif containing 14). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Liver (RPKM 68.8), Testes (RPKM 56.3) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 5q22

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	5	NC_086023.1 (65596149..65620434, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	5	NC_051340.1 (60800568..60824858, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	5	NC_005104.4 (62128941..62154424, complement)

Chromosome 5 - NC_086023.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Trim14-IkappaBalpha Signaling Regulates Chronic Inflammatory Pain in Rats and Osteoarthritis Patients.
Title: Trim14-IκBα Signaling Regulates Chronic Inflammatory Pain in Rats and Osteoarthritis Patients.
RNF125, transcriptionally regulated by NFATC2, alleviates osteoarthritis via inhibiting the Wnt/beta-catenin signaling pathway through degrading TRIM14.
Title: RNF125, transcriptionally regulated by NFATC2, alleviates osteoarthritis via inhibiting the Wnt/β-catenin signaling pathway through degrading TRIM14.
Tripartite motif-containing 14 may aggravate cardiac hypertrophy via the AKT signalling pathway in neonatal rat cardiomyocytes and transgenic mice.
Title: Tripartite motif‑containing 14 may aggravate cardiac hypertrophy via the AKT signalling pathway in neonatal rat cardiomyocytes and transgenic mice.
Inhibition of TRIM14 protects cerebral ischemia/reperfusion injury through regulating NF-kappaB/NLRP3 pathway-mediated inflammation and apoptosis.
Title: Inhibition of TRIM14 protects cerebral ischemia/reperfusion injury through regulating NF-κB/NLRP3 pathway-mediated inflammation and apoptosis.

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General gene information

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Markers

RH128997 (e-PCR)
- UniSTS:212305

RH137252 (e-PCR)
- UniSTS:219340

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables molecular adaptor activity	ISO Inferred from Sequence Orthology more info
enables transcription coactivator activity	ISO Inferred from Sequence Orthology more info
enables ubiquitin protein ligase activity	IBA Inferred from Biological aspect of Ancestor more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info
involved_in inflammatory response	ISO Inferred from Sequence Orthology more info
involved_in innate immune response	IBA Inferred from Biological aspect of Ancestor more info
involved_in innate immune response	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of viral transcription	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA-binding transcription factor activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of NF-kappaB transcription factor activity	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: tripartite motif-containing protein 14

Names: tripartite motif protein 14

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001107934.3 → NP_001101404.1 tripartite motif-containing protein 14 isoform 2

See identical proteins and their annotated locations for NP_001101404.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000005

UniProtKB/TrEMBL

A6IJC4, D3ZBI1

Related

ENSRNOP00000111077.1, ENSRNOT00000159497.1

Conserved Domains (2) summary

pfam00643
Location:20 → 56

zf-B_box; B-box zinc finger

cd13738
Location:204 → 376

SPRY_PRY_TRIM14; PRY/SPRY domain of tripartite motif-binding protein 14 (TRIM14)
NM_001399174.2 → NP_001386103.1 tripartite motif-containing protein 14 isoform 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000005

UniProtKB/TrEMBL

B2RYH2

Related

ENSRNOP00000088241.1, ENSRNOT00000107290.2

Conserved Domains (2) summary

cd13738
Location:267 → 439

SPRY_PRY_TRIM14; PRY/SPRY domain of tripartite motif-binding protein 14 (TRIM14)

cd19768
Location:20 → 63

Bbox2_TRIM14; B-box-type 2 zinc finger found in tripartite motif-containing protein 14 (TRIM14) and similar proteins

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086023.1 Reference GRCr8

Range

65596149..65620434 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006238062.5 → XP_006238124.1 tripartite motif-containing protein 14 isoform X1

See identical proteins and their annotated locations for XP_006238124.1

Conserved Domains (1) summary

cd13738
Location:198 → 370

SPRY_PRY_TRIM14; PRY/SPRY domain of tripartite motif-binding protein 14 (TRIM14)
XM_006238061.4 → XP_006238123.1 tripartite motif-containing protein 14 isoform X1

See identical proteins and their annotated locations for XP_006238123.1

Conserved Domains (1) summary

cd13738
Location:198 → 370

SPRY_PRY_TRIM14; PRY/SPRY domain of tripartite motif-binding protein 14 (TRIM14)
XM_039109868.2 → XP_038965796.1 tripartite motif-containing protein 14 isoform X2

Conserved Domains (1) summary

cd13738
Location:112 → 284

SPRY_PRY_TRIM14; PRY/SPRY domain of tripartite motif-binding protein 14 (TRIM14)
XM_039109869.2 → XP_038965797.1 tripartite motif-containing protein 14 isoform X2

Conserved Domains (1) summary

cd13738
Location:112 → 284

SPRY_PRY_TRIM14; PRY/SPRY domain of tripartite motif-binding protein 14 (TRIM14)