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    Scel sciellin [ Rattus norvegicus (Norway rat) ]

    Gene ID: 361086, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Scelprovided by RGD
    Official Full Name
    sciellinprovided by RGD
    Primary source
    RGD:1305102
    See related
    EnsemblRapid:ENSRNOG00000024237 AllianceGenome:RGD:1305102
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable metal ion binding activity. Predicted to be involved in several processes, including keratinocyte differentiation; positive regulation of canonical Wnt signaling pathway; and response to mechanical stimulus. Predicted to be located in perinuclear region of cytoplasm. Predicted to be active in cytoplasm. Orthologous to human SCEL (sciellin). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Lung (RPKM 27.6), Thymus (RPKM 21.2) and 6 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Scel in Genome Data Viewer
    Location:
    15q21
    Exon count:
    33
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 15 NC_086033.1 (86754595..86871200)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 15 NC_051350.1 (80339661..80456546)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (87689190..87820731)

    Chromosome 15 - NC_086033.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC100909907 Neighboring gene uncharacterized LOC120097171 Neighboring gene 60S ribosomal protein L29 pseudogene Neighboring gene SLAIN motif family, member 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Sciellin mediates mesenchymal-to-epithelial transition in colorectal cancer hepatic metastasis. Chou CK, et al. Oncotarget, 2016 May 3. PMID 27013588, Free PMC Article
    2. cDNA cloning and characterization of sciellin, a LIM domain protein of the keratinocyte cornified envelope. Champliaud MF, et al. J Biol Chem, 1998 Nov 20. PMID 9813070
    3. Gene characterization of sciellin (SCEL) and protein localization in vertebrate epithelia displaying barrier properties. Champliaud MF, et al. Genomics, 2000 Dec 1. PMID 11112355
    4. The expression of vitamin D-upregulated protein 1 in skin and its interaction with sciellin in cultured keratinocytes. Champliaud MF, et al. J Invest Dermatol, 2003 Oct. PMID 14632196
    5. Biomechanical stress induces novel arterial intima-enriched genes: implications for vascular adaptation to stress. Pyle AL, et al. Cardiovasc Pathol, 2010 Mar-Apr. PMID 19211270, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in embryo development ending in birth or egg hatching ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in epidermis development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in epidermis development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in keratinocyte differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of canonical Wnt signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to mechanical stimulus ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    sciellin

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108388.1 → NP_001101858.1  sciellin isoform 3

      See identical proteins and their annotated locations for NP_001101858.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473951
      UniProtKB/TrEMBL
      A0A8I6A4F3, A6HUA0, G3V921
      Related
      ENSRNOP00000033633.4, ENSRNOT00000034987.7
      Conserved Domains (1) summary
      smart00132
      Location:584 → 642
      LIM; Zinc-binding domain present in Lin-11, Isl-1, Mec-3

    2. NM_001431587.1 → NP_001418516.1  sciellin isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000015
      UniProtKB/TrEMBL
      A0A0G2K292, A0A8I6A4F3

    3. NM_001431588.1 → NP_001418517.1  sciellin isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000015
      UniProtKB/TrEMBL
      A0A8I5ZUX7, A0A8I6A4F3

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086033.1 Reference GRCr8

      Range
      86754595..86871200
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006252428.5 → XP_006252490.1  sciellin isoform X1

      Related
      ENSRNOP00000072151.1, ENSRNOT00000082688.3
      Conserved Domains (1) summary
      smart00132
      Location:604 → 662
      LIM; Zinc-binding domain present in Lin-11, Isl-1, Mec-3

    2. XM_039093531.2 → XP_038949459.1  sciellin isoform X2

      Related
      ENSRNOP00000082432.1, ENSRNOT00000094563.2
      Conserved Domains (1) summary
      smart00132
      Location:585 → 643
      LIM; Zinc-binding domain present in Lin-11, Isl-1, Mec-3

    3. XM_039093532.2 → XP_038949460.1  sciellin isoform X3

      Conserved Domains (1) summary
      smart00132
      Location:420 → 478
      LIM; Zinc-binding domain present in Lin-11, Isl-1, Mec-3
    Nucleotide Protein Strain
    Heading Accession and Version

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