Adam15 ADAM metallopeptidase domain 15 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Adam15provided by RGD
Official Full Name: ADAM metallopeptidase domain 15provided by RGD
Primary source: RGD:620402
See related: EnsemblRapid:ENSRNOG00000020590 AllianceGenome:RGD:620402
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: MDC15; tMDCVI
Summary: Predicted to enable SH3 domain binding activity; metalloendopeptidase activity; and signaling receptor binding activity. Involved in male gonad development; response to hypobaric hypoxia; and tissue regeneration. Predicted to be located in cell surface and extracellular exosome. Predicted to be active in extracellular space. Orthologous to human ADAM15 (ADAM metallopeptidase domain 15). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Lung (RPKM 106.5), Heart (RPKM 98.6) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 2q34

Exon count:: 24

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	2	NC_086020.1 (177052363..177062879, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	2	NC_051337.1 (174754629..174765136, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	2	NC_005101.4 (188661831..188672337, complement)

Chromosome 2 - NC_086020.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The present findings implicate ADAM15 in the processes of neuronal hypoxic injury
Title: Differential expression of ADAM15 and ADAM17 metalloproteases in the rat brain after severe hypobaric hypoxia and hypoxic preconditioning.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH135252 (e-PCR)
- UniSTS:218529

RH139781 (e-PCR)
- UniSTS:221865

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables SH3 domain binding	ISO Inferred from Sequence Orthology more info
enables immunoglobulin receptor binding	ISO Inferred from Sequence Orthology more info
enables integrin binding	IBA Inferred from Biological aspect of Ancestor more info
enables integrin binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables metalloendopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables metalloendopeptidase activity	IEA Inferred from Electronic Annotation more info
enables metalloendopeptidase activity	TAS Traceable Author Statement more info	PubMed
enables metallopeptidase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in angiogenesis	IEA Inferred from Electronic Annotation more info
NOT involved_in apoptotic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cardiac epithelial to mesenchymal transition	ISO Inferred from Sequence Orthology more info
involved_in cell-cell adhesion	TAS Traceable Author Statement more info	PubMed
involved_in cellular response to phorbol 13-acetate 12-myristate	ISO Inferred from Sequence Orthology more info
involved_in collagen catabolic process	IEA Inferred from Electronic Annotation more info
involved_in immune response to tumor cell	ISO Inferred from Sequence Orthology more info
involved_in innate immune response	IBA Inferred from Biological aspect of Ancestor more info
involved_in innate immune response	ISO Inferred from Sequence Orthology more info
involved_in integrin-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in integrin-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in male gonad development	IEP Inferred from Expression Pattern more info	PubMed
involved_in negative regulation of cell growth	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell migration	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell-matrix adhesion	ISO Inferred from Sequence Orthology more info
involved_in proteolysis	IBA Inferred from Biological aspect of Ancestor more info
involved_in proteolysis	IEA Inferred from Electronic Annotation more info
involved_in response to hypobaric hypoxia	IEP Inferred from Expression Pattern more info	PubMed
involved_in tissue regeneration	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
located_in acrosomal vesicle	IEA Inferred from Electronic Annotation more info
located_in adherens junction	IEA Inferred from Electronic Annotation more info
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in extracellular exosome	ISO Inferred from Sequence Orthology more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in motile cilium	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: disintegrin and metalloproteinase domain-containing protein 15

Names: ADAM 15; CRII-7; MDC-15; a disintegrin and metallopeptidase domain 15 (metargidin); a disintegrin and metalloproteinase domain 15 (metargidin); metalloprotease RGD disintegrin protein; metalloproteinase-like, disintegrin-like, and cysteine-rich protein 15; metargidin; tMDC VI

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001399128.1 → NP_001386057.1 disintegrin and metalloproteinase domain-containing protein 15 isoform 1 precursor

Status: VALIDATED

Source sequence(s)

JAXUCZ010000002

UniProtKB/Swiss-Prot

Q6P779, Q9QYV0

Related

ENSRNOP00000100663.1, ENSRNOT00000125476.1

Conserved Domains (4) summary

smart00050
Location:432 → 505

DISIN; Homologues of snake disintegrins

smart00608
Location:510 → 651

ACR; ADAM Cysteine-Rich Domain

cd04269
Location:215 → 413

ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...

pfam01562
Location:63 → 155

Pep_M12B_propep; Reprolysin family propeptide
NM_001399129.1 → NP_001386058.1 disintegrin and metalloproteinase domain-containing protein 15 isoform 2 precursor

Status: VALIDATED

Source sequence(s)

JAXUCZ010000002

Related

ENSRNOP00000027970.3, ENSRNOT00000027970.6

Conserved Domains (4) summary

smart00050
Location:443 → 516

DISIN; Homologues of snake disintegrins

smart00608
Location:521 → 662

ACR; ADAM Cysteine-Rich Domain

cd04269
Location:226 → 424

ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...

pfam01562
Location:63 → 155

Pep_M12B_propep; Reprolysin family propeptide
NM_020308.2 → NP_064704.1 disintegrin and metalloproteinase domain-containing protein 15 isoform 3 precursor

See identical proteins and their annotated locations for NP_064704.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000002

UniProtKB/TrEMBL

A6J6F0

Conserved Domains (5) summary

smart00050
Location:432 → 505

DISIN; Homologues of snake disintegrins

smart00608
Location:510 → 651

ACR; ADAM Cysteine-Rich Domain

cd04269
Location:215 → 413

ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...

pfam01421
Location:215 → 416

Reprolysin; Reprolysin (M12B) family zinc metalloprotease

pfam01562
Location:67 → 155

Pep_M12B_propep; Reprolysin family propeptide

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086020.1 Reference GRCr8

Range

177052363..177062879 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_008761203.4 → XP_008759425.1 disintegrin and metalloproteinase domain-containing protein 15 isoform X1

Related

ENSRNOP00000039351.3, ENSRNOT00000050868.6

Conserved Domains (5) summary

smart00050
Location:443 → 516

DISIN; Homologues of snake disintegrins

smart00608
Location:521 → 662

ACR; ADAM Cysteine-Rich Domain

cd04269
Location:226 → 424

ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...

pfam01421
Location:226 → 427

Reprolysin; Reprolysin (M12B) family zinc metalloprotease

pfam01562
Location:67 → 155

Pep_M12B_propep; Reprolysin family propeptide
XM_006232744.5 → XP_006232806.1 disintegrin and metalloproteinase domain-containing protein 15 isoform X4

UniProtKB/TrEMBL

A0A8I6AF83

Related

ENSRNOP00000091249.1, ENSRNOT00000105677.2

Conserved Domains (5) summary

smart00050
Location:432 → 505

DISIN; Homologues of snake disintegrins

smart00608
Location:510 → 651

ACR; ADAM Cysteine-Rich Domain

cd04269
Location:215 → 413

ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...

pfam01421
Location:215 → 416

Reprolysin; Reprolysin (M12B) family zinc metalloprotease

pfam01562
Location:67 → 155

Pep_M12B_propep; Reprolysin family propeptide
XM_008761204.4 → XP_008759426.1 disintegrin and metalloproteinase domain-containing protein 15 isoform X3

Conserved Domains (5) summary

smart00050
Location:443 → 516

DISIN; Homologues of snake disintegrins

smart00608
Location:521 → 662

ACR; ADAM Cysteine-Rich Domain

cd04269
Location:226 → 424

ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...

pfam01421
Location:226 → 427

Reprolysin; Reprolysin (M12B) family zinc metalloprotease

pfam01562
Location:67 → 155

Pep_M12B_propep; Reprolysin family propeptide
XM_063282423.1 → XP_063138493.1 disintegrin and metalloproteinase domain-containing protein 15 isoform X5

Related

ENSRNOP00000109701.1, ENSRNOT00000167246.1
XM_017591056.3 → XP_017446545.1 disintegrin and metalloproteinase domain-containing protein 15 isoform X2