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    Eif2ak1 eukaryotic translation initiation factor 2 alpha kinase 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 27137, updated on 9-Dec-2024

    Summary

    Official Symbol
    Eif2ak1provided by RGD
    Official Full Name
    eukaryotic translation initiation factor 2 alpha kinase 1provided by RGD
    Primary source
    RGD:70883
    See related
    EnsemblRapid:ENSRNOG00000001050 AllianceGenome:RGD:70883
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Hri
    Summary
    Enables eukaryotic translation initiation factor 2alpha kinase activity. Predicted to be involved in several processes, including HRI-mediated signaling; regulation of protein metabolic process; and response to iron ion starvation. Predicted to act upstream of or within several processes, including macrophage differentiation; multicellular organismal-level iron ion homeostasis; and regulation of protein metabolic process. Predicted to be active in cytosol and nucleus. Orthologous to human EIF2AK1 (eukaryotic translation initiation factor 2 alpha kinase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Spleen (RPKM 357.3), Adrenal (RPKM 259.5) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Eif2ak1 in Genome Data Viewer
    Location:
    12p11
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (15824431..15858266, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (10710771..10744597, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (12749026..12782078, complement)

    Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene radial spoke head 10 homolog B Neighboring gene small nucleolar RNA SNORA51 Neighboring gene PMS1 homolog 2, mismatch repair system component Neighboring gene aminoacyl tRNA synthetase complex-interacting multifunctional protein 2 Neighboring gene ankyrin repeat domain 61 Neighboring gene aldolase, fructose-bisphosphate A, pseudogene 3 Neighboring gene ubiquitin specific peptidase 42 Neighboring gene uncharacterized LOC134481266

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Pathways from PubChem

    General gene information

    Gene Ontology Provided by RGD

    Items 1 - 25 of 34
    Function Evidence Code Pubs
    enables 3-phosphoinositide-dependent protein kinase activity  
    enables AMP-activated protein kinase activity  
    enables ATP binding  
    enables DNA-dependent protein kinase activity  
    enables Rho-dependent protein serine/threonine kinase activity  
    enables eukaryotic translation initiation factor 2alpha kinase activity  
    enables eukaryotic translation initiation factor 2alpha kinase activity PubMed 
    enables eukaryotic translation initiation factor 2alpha kinase activity  
    enables eukaryotic translation initiation factor 2alpha kinase activity  
    enables eukaryotic translation initiation factor 2alpha kinase activity  
    enables heme binding  
    enables heme binding  
    enables heme binding  
    enables histone H2AS1 kinase activity  
    enables histone H2AS121 kinase activity  
    enables histone H2AT120 kinase activity  
    enables histone H2AXS139 kinase activity  
    enables histone H2BS14 kinase activity  
    enables histone H2BS36 kinase activity  
    enables histone H3S10 kinase activity  
    enables histone H3S28 kinase activity  
    enables histone H3S57 kinase activity  
    enables histone H3T11 kinase activity  
    enables histone H3T3 kinase activity  
    enables histone H3T45 kinase activity  
    enables histone H3T6 kinase activity  
    enables histone H4S1 kinase activity  
    enables protein homodimerization activity  
    enables protein homodimerization activity  
    enables protein homodimerization activity  
    enables protein kinase activity  
    enables protein serine kinase activity  
    enables protein serine/threonine kinase activity  
    enables ribosomal protein S6 kinase activity  
    Items 1 - 25 of 34
    Items 1 - 25 of 42
    Process Evidence Code Pubs
    involved_in HRI-mediated signaling  
    involved_in HRI-mediated signaling  
    involved_in HRI-mediated signaling  
    involved_in acute inflammatory response  
    acts_upstream_of_or_within acute inflammatory response  
    involved_in chromatin remodeling  
    involved_in establishment of localization in cell  
    acts_upstream_of_or_within establishment of localization in cell  
    involved_in integrated stress response signaling  
    involved_in integrated stress response signaling  
    involved_in macrophage differentiation  
    acts_upstream_of_or_within macrophage differentiation  
    involved_in multicellular organismal-level iron ion homeostasis  
    acts_upstream_of_or_within multicellular organismal-level iron ion homeostasis  
    involved_in negative regulation of cell population proliferation  
    involved_in negative regulation of cell population proliferation  
    involved_in negative regulation of cell population proliferation  
    involved_in negative regulation of hemoglobin biosynthetic process  
    involved_in negative regulation of hemoglobin biosynthetic process  
    involved_in negative regulation of hemoglobin biosynthetic process  
    involved_in negative regulation of translation  
    involved_in phagocytosis  
    acts_upstream_of_or_within phagocytosis  
    involved_in positive regulation of mitophagy  
    involved_in positive regulation of mitophagy  
    involved_in positive regulation of mitophagy  
    involved_in protein autophosphorylation  
    involved_in protein autophosphorylation  
    involved_in protein localization to mitochondrion  
    involved_in protein localization to mitochondrion  
    involved_in protoporphyrinogen IX metabolic process  
    acts_upstream_of_or_within protoporphyrinogen IX metabolic process  
    acts_upstream_of_or_within regulation of eIF2 alpha phosphorylation by heme  
    acts_upstream_of_or_within regulation of hemoglobin biosynthetic process  
    involved_in regulation of metabolic process  
    involved_in regulation of translation  
    acts_upstream_of_or_within regulation of translation  
    involved_in regulation of translational initiation  
    involved_in response to iron ion starvation  
    involved_in response to iron ion starvation  
    involved_in response to iron ion starvation  
    involved_in response to stress  
    Items 1 - 25 of 42
    Component Evidence Code Pubs
    is_active_in cytoplasm  
    located_in cytoplasm  
    located_in cytoplasm  
    located_in cytosol  
    is_active_in cytosol  
    is_active_in nucleus  

    General protein information

    Preferred Names
    eukaryotic translation initiation factor 2-alpha kinase 1
    Names
    HCR
    heme-controlled repressor
    heme-regulated eukaryotic initiation factor eIF-2-alpha kinase
    heme-regulated inhibitor
    hemin-sensitive initiation factor 2-alpha kinase
    hemin-sensitive initiation factor 2a kinase
    NP_037355.2
    XP_038945063.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_013223.2NP_037355.2  eukaryotic translation initiation factor 2-alpha kinase 1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000012
      UniProtKB/Swiss-Prot
      Q63185, Q642C7
      Related
      ENSRNOP00000001392.5, ENSRNOT00000001392.10
      Conserved Domains (1) summary
      cd14049
      Location:160579
      STKc_EIF2AK1_HRI; Catalytic domain of the Serine/Threonine kinase, eukaryotic translation Initiation Factor 2-Alpha Kinase 2 or Heme-Regulated Inhibitor kinase

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086030.1 Reference GRCr8

      Range
      15824431..15858266 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039089135.2XP_038945063.1  eukaryotic translation initiation factor 2-alpha kinase 1 isoform X1

      UniProtKB/TrEMBL
      A0A0G2K9K9
      Related
      ENSRNOP00000075036.1, ENSRNOT00000079836.3
      Conserved Domains (1) summary
      cd14049
      Location:160604
      STKc_EIF2AK1_HRI; Catalytic domain of the Serine/Threonine kinase, eukaryotic translation Initiation Factor 2-Alpha Kinase 2 or Heme-Regulated Inhibitor kinase
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