Igfals insulin-like growth factor binding protein, acid labile subunit [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Igfalsprovided by RGD
Official Full Name: insulin-like growth factor binding protein, acid labile subunitprovided by RGD
Primary source: RGD:68429
See related: EnsemblRapid:ENSRNOG00000015061 AllianceGenome:RGD:68429
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Als
Summary: Enables insulin-like growth factor binding activity. Involved in several processes, including cellular response to dexamethasone stimulus; cellular response to epidermal growth factor stimulus; and cellular response to growth hormone stimulus. Part of insulin-like growth factor ternary complex. Orthologous to human IGFALS (insulin like growth factor binding protein acid labile subunit). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Liver (RPKM 342.9) and Kidney (RPKM 47.2) See more
Orthologs: human mouse all
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Genomic context

Location:: 10q12

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (14397076..14408439)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (13897468..13903920)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (14240308..14243554)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

in sustained endotoxemia, ALS levels are regulated through modulation of hepatic insulin sensitivity.
Title: Regulation of the acid-labile subunit in sustained endotoxemia.
hypothesize that development-dependent regulation of ALS and IGF-I during refeeding may involve a posttranscriptional hepatic response that is not growth hormone dependent
Title: Age-dependent regulation of the acid-labile subunit in response to fasting-refeeding in rats.

Submit: New GeneRIF Correction

General gene information

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Markers

RH128916 (e-PCR)
- UniSTS:212224

RH138690 (e-PCR)
- UniSTS:220777

D5S619 (e-PCR), detects polymorphism
- UniSTS:12022

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables insulin-like growth factor binding	IBA Inferred from Biological aspect of Ancestor more info
enables insulin-like growth factor binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in cell adhesion	IEA Inferred from Electronic Annotation more info
involved_in cellular response to dexamethasone stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to epidermal growth factor stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to growth hormone stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to interleukin-1	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to nutrient levels	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
is_active_in extracellular matrix	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in focal adhesion	IEA Inferred from Electronic Annotation more info
part_of insulin-like growth factor ternary complex	IBA Inferred from Biological aspect of Ancestor more info
part_of insulin-like growth factor ternary complex	IDA Inferred from Direct Assay more info	PubMed
part_of insulin-like growth factor ternary complex	IEA Inferred from Electronic Annotation more info
part_of insulin-like growth factor ternary complex	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: insulin-like growth factor-binding protein complex acid labile subunit

Names: insulin-like growth factor-binding protein complex acid labile chain

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_053329.3 → NP_445781.3 insulin-like growth factor-binding protein complex acid labile subunit precursor

Status: VALIDATED

Source sequence(s)

JAXUCZ010000010

UniProtKB/TrEMBL

A6HCX9, F1LRE2, O70211

Related

ENSRNOP00000020233.5, ENSRNOT00000020233.7

Conserved Domains (5) summary

smart00013
Location:40 → 78

LRRNT; Leucine rich repeat N-terminal domain

PLN00113
Location:68 → 494

PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional

sd00033
Location:244 → 267

LRR_RI; leucine-rich repeat [structural motif]

pfam13855
Location:486 → 536

LRR_8; Leucine rich repeat

cl15307
Location:535 → 578

TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086028.1 Reference GRCr8

Range

14397076..14408439

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039086922.2 → XP_038942850.1 insulin-like growth factor-binding protein complex acid labile subunit isoform X1

UniProtKB/TrEMBL

A0A8I5Y6E1, A6HCX8, O70211

Conserved Domains (5) summary

smart00013
Location:40 → 78

LRRNT; Leucine rich repeat N-terminal domain

PLN00113
Location:68 → 494

PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional

sd00033
Location:244 → 267

LRR_RI; leucine-rich repeat [structural motif]

pfam13855
Location:486 → 536

LRR_8; Leucine rich repeat

cl15307
Location:535 → 578

TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
XM_063269930.1 → XP_063126000.1 insulin-like growth factor-binding protein complex acid labile subunit isoform X2