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    Med28 mediator complex subunit 28 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 305391, updated on 9-Dec-2024

    Summary

    Official Symbol
    Med28provided by RGD
    Official Full Name
    mediator complex subunit 28provided by RGD
    Primary source
    RGD:1305875
    See related
    EnsemblRapid:ENSRNOG00000003592 AllianceGenome:RGD:1305875
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Eg1; FKSG20; RGD1305875
    Summary
    Predicted to enable actin binding activity. Predicted to act upstream of or within negative regulation of smooth muscle cell differentiation and somatic stem cell population maintenance. Predicted to be located in cortical actin cytoskeleton and nucleoplasm. Predicted to be part of core mediator complex and mediator complex. Orthologous to human MED28 (mediator complex subunit 28). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Testes (RPKM 149.5), Kidney (RPKM 142.3) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Med28 in Genome Data Viewer
    Location:
    14q11
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (69807319..69816115, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (65594785..65603583, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (70089225..70098021, complement)

    Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120096619 Neighboring gene DDB1 and CUL4 associated factor 16 Neighboring gene family with sequence similarity 184, member B Neighboring gene uncharacterized LOC134481758 Neighboring gene leucine aminopeptidase 3 Neighboring gene uncharacterized LOC134481759

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables actin binding  
    Component Evidence Code Pubs
    part_of core mediator complex  
    located_in cortical actin cytoskeleton  
    located_in cytoskeleton  
    part_of mediator complex  
    located_in membrane  
    located_in nucleoplasm  
    located_in nucleoplasm  
    located_in nucleus  
    located_in nucleus  

    General protein information

    Preferred Names
    mediator of RNA polymerase II transcription subunit 28
    Names
    endothelial-derived
    mediator of RNA polymerase II transcription, subunit 28 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107217.1NP_001100687.1  mediator of RNA polymerase II transcription subunit 28

      See identical proteins and their annotated locations for NP_001100687.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473963
      UniProtKB/Swiss-Prot
      P68943
      UniProtKB/TrEMBL
      A0A8I6ATY3, A6IJL3
      Related
      ENSRNOP00000004912.4, ENSRNOT00000004912.7
      Conserved Domains (1) summary
      pfam11594
      Location:43143
      Med28; Mediator complex subunit 28

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086032.1 Reference GRCr8

      Range
      69807319..69816115 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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