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    Eme2 essential meiotic structure-specific endonuclease subunit 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 302982, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Eme2provided by RGD
    Official Full Name
    essential meiotic structure-specific endonuclease subunit 2provided by RGD
    Primary source
    RGD:1304924
    See related
    EnsemblRapid:ENSRNOG00000024867 AllianceGenome:RGD:1304924
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1304924
    Summary
    Predicted to enable DNA binding activity. Predicted to contribute to crossover junction DNA endonuclease activity. Predicted to be involved in DNA metabolic process and mitotic intra-S DNA damage checkpoint signaling. Predicted to be located in nucleus. Predicted to be part of Holliday junction resolvase complex. Orthologous to human EME2 (essential meiotic structure-specific endonuclease subunit 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 161.4), Kidney (RPKM 145.1) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Eme2 in Genome Data Viewer
    Location:
    10q12
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (14413661..14420489, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (13913216..13915991, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (14253552..14257017, complement)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene transfer RNA proline (anticodon AGG) 67 Neighboring gene hydroxyacyl glutathione hydrolase Neighboring gene insulin-like growth factor binding protein, acid labile subunit Neighboring gene NUBP iron-sulfur cluster assembly factor 2 Neighboring gene splA/ryanodine receptor domain and SOCS box containing 3 Neighboring gene mitochondrial ribosomal protein S34 Neighboring gene NME/NM23 nucleoside diphosphate kinase 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    contributes_to crossover junction DNA endonuclease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in double-strand break repair IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in double-strand break repair ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mitotic intra-S DNA damage checkpoint signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in replication fork processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in replication fork processing ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in resolution of meiotic recombination intermediates IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of Holliday junction resolvase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of endodeoxyribonuclease complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    probable crossover junction endonuclease EME2
    Names
    essential meiotic endonuclease 1 homolog 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001401947.1 → NP_001388876.1  probable crossover junction endonuclease EME2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/TrEMBL
      A6HCY3, D3ZC60
      Related
      ENSRNOP00000029188.6, ENSRNOT00000030458.8

    2. NM_001401948.1 → NP_001388877.1  probable crossover junction endonuclease EME2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      Related
      ENSRNOP00000106725.1, ENSRNOT00000144138.1

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      14413661..14420489 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039087091.2 → XP_038943019.1  probable crossover junction endonuclease EME2 isoform X7

      UniProtKB/TrEMBL
      A6HCY3
      Conserved Domains (1) summary
      cl41760
      Location:66 → 260
      XPF_nuclease-like; nuclease domain of XPF/MUS81 family proteins

    2. XM_039087089.2 → XP_038943017.1  probable crossover junction endonuclease EME2 isoform X5

      Conserved Domains (1) summary
      cl41760
      Location:66 → 256
      XPF_nuclease-like; nuclease domain of XPF/MUS81 family proteins

    3. XM_039087083.2 → XP_038943011.1  probable crossover junction endonuclease EME2 isoform X1

      Conserved Domains (1) summary
      cl41760
      Location:66 → 188
      XPF_nuclease-like; nuclease domain of XPF/MUS81 family proteins

    4. XM_017597598.3 → XP_017453087.1  probable crossover junction endonuclease EME2 isoform X2

      UniProtKB/TrEMBL
      B0BNI8
      Conserved Domains (1) summary
      cl41760
      Location:66 → 188
      XPF_nuclease-like; nuclease domain of XPF/MUS81 family proteins

    5. XM_063268922.1 → XP_063124992.1  probable crossover junction endonuclease EME2 isoform X6

    6. XM_039087088.2 → XP_038943016.1  probable crossover junction endonuclease EME2 isoform X4

      Conserved Domains (1) summary
      cl41760
      Location:66 → 256
      XPF_nuclease-like; nuclease domain of XPF/MUS81 family proteins

    7. XM_039087087.2 → XP_038943015.1  probable crossover junction endonuclease EME2 isoform X3

      Conserved Domains (1) summary
      cl41760
      Location:66 → 255
      XPF_nuclease-like; nuclease domain of XPF/MUS81 family proteins

    8. XM_039087084.2 → XP_038943012.1  probable crossover junction endonuclease EME2 isoform X2

      UniProtKB/TrEMBL
      B0BNI8
      Conserved Domains (1) summary
      cl41760
      Location:66 → 188
      XPF_nuclease-like; nuclease domain of XPF/MUS81 family proteins

    9. XM_063268921.1 → XP_063124991.1  probable crossover junction endonuclease EME2 isoform X2

      UniProtKB/TrEMBL
      B0BNI8

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001129775.1: Suppressed sequence

      Description
      NM_001129775.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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