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    Hs3st5 heparan sulfate-glucosamine 3-sulfotransferase 5 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 294449, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Hs3st5provided by RGD
    Official Full Name
    heparan sulfate-glucosamine 3-sulfotransferase 5provided by RGD
    Primary source
    RGD:1306379
    See related
    EnsemblRapid:ENSRNOG00000000605 AllianceGenome:RGD:1306379
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity. Predicted to be involved in several processes, including heparan sulfate proteoglycan biosynthetic process, enzymatic modification; protein sulfation; and regulation of viral entry into host cell. Orthologous to human HS3ST5 (heparan sulfate-glucosamine 3-sulfotransferase 5). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Heart (RPKM 38.1), Brain (RPKM 23.9) and 4 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Hs3st5 in Genome Data Viewer
    Location:
    20q12
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 20 NC_086038.1 (41661785..41972550)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 20 NC_051355.1 (40106876..40417661)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 20 NC_005119.4 (40236437..40545502)

    Chromosome 20 - NC_086038.1Genomic Context describing neighboring genes Neighboring gene ribosomal protein S8, pseudogene 3 Neighboring gene peptidylprolyl isomerase D, pseudogene 15 Neighboring gene uncharacterized LOC134483815 Neighboring gene transfer RNA threonine (anticodon AGU) 35 Neighboring gene ribosomal protein L13A, pseudogene 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Characterization of a heparan sulfate 3-O-sulfotransferase-5, an enzyme synthesizing a tetrasulfated disaccharide. Mochizuki H, et al. J Biol Chem, 2003 Jul 18. PMID 12740361
    2. Heparan sulfate 3-O-sulfotransferase isoform 5 generates both an antithrombin-binding site and an entry receptor for herpes simplex virus, type 1. Xia G, et al. J Biol Chem, 2002 Oct 4. PMID 12138164
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in heparan sulfate proteoglycan biosynthetic process, enzymatic modification ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of coagulation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein sulfation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of viral entry into host cell ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    heparan sulfate glucosamine 3-O-sulfotransferase 5
    Names
    heparan sulfate (glucosamine) 3-O-sulfotransferase 5
    NP_001099862.1
    XP_017457112.1
    XP_017457114.1
    XP_017457115.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001106392.1 → NP_001099862.1  heparan sulfate glucosamine 3-O-sulfotransferase 5

      See identical proteins and their annotated locations for NP_001099862.1

      Status: PROVISIONAL

      Source sequence(s)
      CH474051
      UniProtKB/TrEMBL
      A6KID5, D3ZDL1
      Conserved Domains (1) summary
      pfam00685
      Location:90 → 330
      Sulfotransfer_1; Sulfotransferase domain

    2. NM_001434620.1 → NP_001421549.1  heparan sulfate glucosamine 3-O-sulfotransferase 5

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000020
      UniProtKB/TrEMBL
      A6KID5, D3ZDL1

    3. NM_001434621.1 → NP_001421550.1  heparan sulfate glucosamine 3-O-sulfotransferase 5

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000020
      UniProtKB/TrEMBL
      A6KID5, D3ZDL1

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086038.1 Reference GRCr8

      Range
      41661785..41972550
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017601626.3 → XP_017457115.1  heparan sulfate glucosamine 3-O-sulfotransferase 5 isoform X1

      Conserved Domains (1) summary
      pfam00685
      Location:90 → 330
      Sulfotransfer_1; Sulfotransferase domain

    2. XM_017601623.3 → XP_017457112.1  heparan sulfate glucosamine 3-O-sulfotransferase 5 isoform X1

      Related
      ENSRNOP00000000743.2, ENSRNOT00000000743.5
      Conserved Domains (1) summary
      pfam00685
      Location:90 → 330
      Sulfotransfer_1; Sulfotransferase domain

    3. XM_017601625.3 → XP_017457114.1  heparan sulfate glucosamine 3-O-sulfotransferase 5 isoform X1

      UniProtKB/TrEMBL
      A6KID5, D3ZDL1
      Conserved Domains (1) summary
      pfam00685
      Location:90 → 330
      Sulfotransfer_1; Sulfotransferase domain
    Nucleotide Protein Strain
    Heading Accession and Version

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