Dnajc19 DnaJ heat shock protein family (Hsp40) member C19 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Dnajc19provided by RGD
Official Full Name: DnaJ heat shock protein family (Hsp40) member C19provided by RGD
Primary source: RGD:1560220
See related: EnsemblRapid:ENSRNOG00000049819 AllianceGenome:RGD:1560220
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1560220
Summary: Predicted to enable ATPase activator activity. Predicted to be involved in several processes, including protein import into mitochondrial matrix; regulation of cardiolipin metabolic process; and visual perception. Predicted to be located in matrix side of mitochondrial inner membrane. Predicted to be part of PAM complex, Tim23 associated import motor. Human ortholog(s) of this gene implicated in 3-methylglutaconic aciduria type 5. Orthologous to human DNAJC19 (DnaJ heat shock protein family (Hsp40) member C19). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Muscle (RPKM 257.9), Heart (RPKM 184.5) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 2q24

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	2	NC_086020.1 (118851497..118875813, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	2	NC_051337.1 (116923272..116945312, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	2	NC_005101.4 (120503093..120531782)

Chromosome 2 - NC_086020.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

RH130227 (e-PCR)
- UniSTS:213514

BI274570 (e-PCR)
- UniSTS:249125

BI281166 (e-PCR)
- UniSTS:249408

RH66895 (e-PCR)
- UniSTS:87633

UniSTS:479111 (e-PCR)
- UniSTS:479111

Fxr1h (e-PCR), detects polymorphism
- UniSTS:479111

G34972 (e-PCR)
- UniSTS:117650

X90875 (e-PCR)
- UniSTS:125882

RH132222 (e-PCR)
- UniSTS:215505

RH139070 (e-PCR)
- UniSTS:221156

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATPase activator activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info
involved_in genitalia development	ISO Inferred from Sequence Orthology more info
involved_in protein import into mitochondrial matrix	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of cardiolipin metabolic process	ISO Inferred from Sequence Orthology more info
involved_in visual perception	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of PAM complex, Tim23 associated import motor	IBA Inferred from Biological aspect of Ancestor more info
part_of inner mitochondrial membrane protein complex	ISO Inferred from Sequence Orthology more info
located_in matrix side of mitochondrial inner membrane	ISO Inferred from Sequence Orthology more info
located_in mitochondrial inner membrane	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: mitochondrial import inner membrane translocase subunit TIM14

Names: DnaJ (Hsp40) homolog, subfamily C, member 19

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001134640.1 → NP_001128112.1 mitochondrial import inner membrane translocase subunit TIM14

See identical proteins and their annotated locations for NP_001128112.1

Status: PROVISIONAL

Source sequence(s)

CH473961

UniProtKB/TrEMBL

A0A8I5ZMN9, A6IHT6, M0R6L8

Conserved Domains (1) summary

cl02542
Location:53 → 94

DnaJ; DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s, ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086020.1 Reference GRCr8

Range

118851497..118875813 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063282411.1 → XP_063138481.1 mitochondrial import inner membrane translocase subunit TIM14 isoform X1
XM_006232259.5 → XP_006232321.1 mitochondrial import inner membrane translocase subunit TIM14 isoform X2

See identical proteins and their annotated locations for XP_006232321.1

UniProtKB/TrEMBL

A0A8I6A7G6, A6IHT7

Related

ENSRNOP00000083629.2, ENSRNOT00000118548.2

Conserved Domains (1) summary

cl02542
Location:53 → 110

DnaJ; DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s, ...