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    Mitd1 microtubule interacting and trafficking domain containing 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 363219, updated on 9-Dec-2024

    Summary

    Official Symbol
    Mitd1provided by RGD
    Official Full Name
    microtubule interacting and trafficking domain containing 1provided by RGD
    Primary source
    RGD:1307700
    See related
    EnsemblRapid:ENSRNOG00000018467 AllianceGenome:RGD:1307700
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1307700
    Summary
    Predicted to enable identical protein binding activity; phosphatidylinositol binding activity; and protein domain specific binding activity. Predicted to be involved in midbody abscission. Predicted to be located in intracellular membrane-bounded organelle and membrane. Predicted to colocalize with midbody. Orthologous to human MITD1 (microtubule interacting and trafficking domain containing 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 96.4), Spleen (RPKM 73.7) and 9 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Mitd1 in Genome Data Viewer
    Location:
    9q21
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (47609743..47621033, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (40113943..40125280, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (44472364..44483723, complement)

    Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene chromosome 9 C2orf15 homolog Neighboring gene lipoyltransferase 1 Neighboring gene mitochondrial ribosomal protein L30 Neighboring gene lysozyme G2

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Markers

    Clone Names

    • MGC109091

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables phosphatidylinositol binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein domain specific binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in midbody abscission IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in midbody abscission ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in mitotic cytokinesis ISO
    Inferred from Sequence Orthology
    more info
     
    NOT involved_in multivesicular body sorting pathway ISO
    Inferred from Sequence Orthology
    more info
     
    NOT involved_in viral budding via host ESCRT complex ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in late endosome membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
     
    colocalizes_with midbody IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in midbody ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    MIT domain-containing protein 1
    Names
    MIT, microtubule interacting and transport, domain containing 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001009714.1NP_001009714.1  MIT domain-containing protein 1

      See identical proteins and their annotated locations for NP_001009714.1

      Status: PROVISIONAL

      Source sequence(s)
      BC088263
      UniProtKB/Swiss-Prot
      Q5I0J5
      UniProtKB/TrEMBL
      A6INI5
      Related
      ENSRNOP00000024959.6, ENSRNOT00000024959.9
      Conserved Domains (2) summary
      cd02683
      Location:1086
      MIT_1; MIT: domain contained within Microtubule Interacting and Trafficking molecules. This sub-family of MIT domains is found in proteins with unknown function, co-occuring with an as yet undescribed domain. The molecular function of the MIT domain is unclear.
      cd02685
      Location:97245
      MIT_C; domain found C-terminal to MIT (contained within Microtubule Interacting and Trafficking molecules) domains, as well as in some bacterial proteins. The function of this domain is unknown.

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086027.1 Reference GRCr8

      Range
      47609743..47621033 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039083841.2XP_038939769.1  MIT domain-containing protein 1 isoform X2

      Conserved Domains (2) summary
      cd02683
      Location:1086
      MIT_1; MIT: domain contained within Microtubule Interacting and Trafficking molecules. This sub-family of MIT domains is found in proteins with unknown function, co-occuring with an as yet undescribed domain. The molecular function of the MIT domain is unclear.
      cl02780
      Location:97216
      MIT_C; domain found C-terminal to MIT (contained within Microtubule Interacting and Trafficking molecules) domains, as well as in some bacterial proteins. The function of this domain is unknown.
    2. XM_006244828.5XP_006244890.1  MIT domain-containing protein 1 isoform X1

      Conserved Domains (2) summary
      cd02683
      Location:1086
      MIT_1; MIT: domain contained within Microtubule Interacting and Trafficking molecules. This sub-family of MIT domains is found in proteins with unknown function, co-occuring with an as yet undescribed domain. The molecular function of the MIT domain is unclear.
      pfam16565
      Location:100230
      MIT_C; Phospholipase D-like domain at C-terminus of MIT
    3. XM_008767036.4XP_008765258.1  MIT domain-containing protein 1 isoform X3

      Conserved Domains (2) summary
      cd02683
      Location:1086
      MIT_1; MIT: domain contained within Microtubule Interacting and Trafficking molecules. This sub-family of MIT domains is found in proteins with unknown function, co-occuring with an as yet undescribed domain. The molecular function of the MIT domain is unclear.
      cl02780
      Location:100198
      MIT_C; MIT_C; domain found C-terminal to MIT (contained within Microtubule Interacting and Trafficking molecules) domains, as well as in some bacterial proteins. The function of this domain is unknown.