Dclk2 doublecortin-like kinase 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Dclk2provided by RGD
Official Full Name: doublecortin-like kinase 2provided by RGD
Primary source: RGD:1308384
See related: EnsemblRapid:ENSRNOG00000016550 AllianceGenome:RGD:1308384
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: CL2; Dck2; CLICK2; CLICK-II; RGD1308384
Summary: This gene encodes a member of the protein kinase superfamily and the doublecortin family. The protein encoded by this gene contains two N-terminal doublecortin domains, which bind microtubules and regulate microtubule polymerization, a C-terminal serine/threonine protein kinase domain, which shows substantial homology to Ca2+/calmoduline-dependent protein kinase, and a serine/proline-rich domain in between the doublecortin and the protein kinase domains, which mediates multiple protein-protein interactions. The microtubule-polymerizing activity of the encoded protein is independent of its protein kinase activity. Mouse studies show that this gene and the DCX gene, another family member, share function in the establishment of hippocampal organization and that their absence results in a severe epileptic phenotype and lethality, as described in human patients with lissencephaly. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Sep 2010]
Expression: Biased expression in Brain (RPKM 74.3), Adrenal (RPKM 64.0) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 2q34

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	2	NC_086020.1 (174506660..174636353, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	2	NC_051337.1 (172202733..172338411, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	2	NC_005101.4 (186116624..186245937, complement)

Chromosome 2 - NC_086020.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Doublecortin kinase-2 is associated with terminal segments of axons and dendrites
Title: Doublecortin kinase-2, a novel doublecortin-related protein kinase associated with terminal segments of axons and dendrites.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D17S1873 (e-PCR)
- UniSTS:38926

BF398261 (e-PCR)
- UniSTS:246726

UniSTS:234717 (e-PCR)
- UniSTS:234717

RH144449 (e-PCR)
- UniSTS:233694

RH142675 (e-PCR)
- UniSTS:231922

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables 3-phosphoinositide-dependent protein kinase activity	IEA Inferred from Electronic Annotation more info
enables AMP-activated protein kinase activity	IEA Inferred from Electronic Annotation more info
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables DNA-dependent protein kinase activity	IEA Inferred from Electronic Annotation more info
enables Rho-dependent protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables eukaryotic translation initiation factor 2alpha kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AS1 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AS121 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AT120 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AXS139 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2BS14 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2BS36 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S10 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S28 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S57 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T11 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T3 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T45 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T6 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H4S1 kinase activity	IEA Inferred from Electronic Annotation more info
enables microtubule binding	IEA Inferred from Electronic Annotation more info
enables microtubule binding	ISO Inferred from Sequence Orthology more info
enables protein kinase activity	IEA Inferred from Electronic Annotation more info
enables protein kinase activity	ISO Inferred from Sequence Orthology more info
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables ribosomal protein S6 kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in hippocampus development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within hippocampus development	ISO Inferred from Sequence Orthology more info
involved_in intracellular signal transduction	IEA Inferred from Electronic Annotation more info
involved_in microtubule cytoskeleton organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in microtubule cytoskeleton organization	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within microtubule cytoskeleton organization	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of protein localization to nucleus	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of protein localization to nucleus	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within peptidyl-serine phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in protein localization to nucleus	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein localization to nucleus	IEA Inferred from Electronic Annotation more info
acts_upstream_of protein localization to nucleus	ISO Inferred from Sequence Orthology more info
involved_in pyramidal neuron development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within pyramidal neuron development	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: serine/threonine-protein kinase DCLK2

Names: caMK-like CREB regulatory kinase 2; doublecortin kinase 2; doublecortin-like and CAM kinase-like 2

NP_001009691.3

EC 2.7.11.1

NP_001182761.1

EC 2.7.11.1

XP_006232742.1

EC 2.7.11.1

XP_006232743.1

EC 2.7.11.1

XP_006232744.1

EC 2.7.11.1

XP_006232746.1

EC 2.7.11.1

XP_006232747.1

EC 2.7.11.1

XP_063137964.1

EC 2.7.11.1

XP_063137965.1

EC 2.7.11.1

XP_063137966.1

EC 2.7.11.1

XP_063137967.1

EC 2.7.11.1

XP_063137968.1

EC 2.7.11.1

XP_063137969.1

EC 2.7.11.1

XP_063137970.1

EC 2.7.11.1

XP_063137971.1

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001009691.3 → NP_001009691.3 serine/threonine-protein kinase DCLK2 isoform b

See identical proteins and their annotated locations for NP_001009691.3

Status: REVIEWED

Description

Transcript Variant: This variant (2) is an exon-5-containing transcript (PMIDs:15611072 and 18075264). It encodes the longer isoform (b).

Source sequence(s)

JAXUCZ010000002

UniProtKB/Swiss-Prot

Q5MPA7, Q5MPA8, Q5MPA9, Q5MPB0

UniProtKB/TrEMBL

A0A8L2RA10

Related

ENSRNOP00000062805.4, ENSRNOT00000066004.6

Conserved Domains (3) summary

smart00220
Location:409 → 666

S_TKc; Serine/Threonine protein kinases, catalytic domain

smart00537
Location:67 → 157

DCX; Domain in the Doublecortin (DCX) gene product

cd14184
Location:407 → 665

STKc_DCKL2; Catalytic domain of the Serine/Threonine Kinase, Doublecortin-like kinase 2 (also called Doublecortin-like and CAM kinase-like 2)
NM_001195832.1 → NP_001182761.1 serine/threonine-protein kinase DCLK2 isoform a

Status: REVIEWED

Description

Transcript Variant: This variant (1) is an exon-5-containing and exon-17-containing transcript (PMIDs:15611072 and 18075264). It has an additional exon in the 3' region, which results in frame-shift, as compared to variant 2. The resulting isoform (a) has a shorter and different C-terminus, as compared to isoform b.

Source sequence(s)

JAXUCZ010000002

UniProtKB/TrEMBL

A0A8L2QVM1

Related

ENSRNOP00000104840.1, ENSRNOT00000164060.1

Conserved Domains (3) summary

smart00220
Location:409 → 666

S_TKc; Serine/Threonine protein kinases, catalytic domain

smart00537
Location:67 → 157

DCX; Domain in the Doublecortin (DCX) gene product

cd14184
Location:407 → 665

STKc_DCKL2; Catalytic domain of the Serine/Threonine Kinase, Doublecortin-like kinase 2 (also called Doublecortin-like and CAM kinase-like 2)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086020.1 Reference GRCr8

Range

174506660..174636353 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063281896.1 → XP_063137966.1 serine/threonine-protein kinase DCLK2 isoform X8

UniProtKB/TrEMBL

A0A8L2QVM1
XM_063281898.1 → XP_063137968.1 serine/threonine-protein kinase DCLK2 isoform X10

UniProtKB/TrEMBL

A0A8L2QQT4
XM_006232685.5 → XP_006232747.1 serine/threonine-protein kinase DCLK2 isoform X6

UniProtKB/TrEMBL

A0A8L2QQT4

Conserved Domains (3) summary

smart00220
Location:392 → 649

S_TKc; Serine/Threonine protein kinases, catalytic domain

smart00537
Location:67 → 157

DCX; Domain in the Doublecortin (DCX) gene product

cd14184
Location:390 → 648

STKc_DCKL2; Catalytic domain of the Serine/Threonine Kinase, Doublecortin-like kinase 2 (also called Doublecortin-like and CAM kinase-like 2)
XM_063281900.1 → XP_063137970.1 serine/threonine-protein kinase DCLK2 isoform X12

UniProtKB/TrEMBL

A0A8L2QVM1
XM_063281894.1 → XP_063137964.1 serine/threonine-protein kinase DCLK2 isoform X4

UniProtKB/TrEMBL

A0A8L2RA10
XM_063281897.1 → XP_063137967.1 serine/threonine-protein kinase DCLK2 isoform X9

UniProtKB/TrEMBL

A0A8L2QVM1
XM_006232684.5 → XP_006232746.1 serine/threonine-protein kinase DCLK2 isoform X5

UniProtKB/TrEMBL

A0A8L2QVM1

Conserved Domains (3) summary

smart00220
Location:409 → 666

S_TKc; Serine/Threonine protein kinases, catalytic domain

smart00537
Location:67 → 157

DCX; Domain in the Doublecortin (DCX) gene product

cd14184
Location:407 → 665

STKc_DCKL2; Catalytic domain of the Serine/Threonine Kinase, Doublecortin-like kinase 2 (also called Doublecortin-like and CAM kinase-like 2)
XM_006232682.5 → XP_006232744.1 serine/threonine-protein kinase DCLK2 isoform X3

UniProtKB/TrEMBL

A0A8L2RA10

Related

ENSRNOP00000022292.8, ENSRNOT00000022292.8

Conserved Domains (3) summary

smart00220
Location:392 → 649

S_TKc; Serine/Threonine protein kinases, catalytic domain

smart00537
Location:67 → 157

DCX; Domain in the Doublecortin (DCX) gene product

cd14184
Location:390 → 648

STKc_DCKL2; Catalytic domain of the Serine/Threonine Kinase, Doublecortin-like kinase 2 (also called Doublecortin-like and CAM kinase-like 2)
XM_006232681.5 → XP_006232743.1 serine/threonine-protein kinase DCLK2 isoform X2

UniProtKB/TrEMBL

A0A8L2RA10

Related

ENSRNOP00000075203.2, ENSRNOT00000079954.3

Conserved Domains (3) summary

smart00220
Location:393 → 650

S_TKc; Serine/Threonine protein kinases, catalytic domain

smart00537
Location:67 → 157

DCX; Domain in the Doublecortin (DCX) gene product

cd14184
Location:391 → 649

STKc_DCKL2; Catalytic domain of the Serine/Threonine Kinase, Doublecortin-like kinase 2 (also called Doublecortin-like and CAM kinase-like 2)
XM_006232680.5 → XP_006232742.1 serine/threonine-protein kinase DCLK2 isoform X1

UniProtKB/TrEMBL

A0A8L2RA10

Conserved Domains (3) summary

smart00220
Location:408 → 665

S_TKc; Serine/Threonine protein kinases, catalytic domain

smart00537
Location:67 → 157

DCX; Domain in the Doublecortin (DCX) gene product

cd14184
Location:406 → 664

STKc_DCKL2; Catalytic domain of the Serine/Threonine Kinase, Doublecortin-like kinase 2 (also called Doublecortin-like and CAM kinase-like 2)
XM_063281899.1 → XP_063137969.1 serine/threonine-protein kinase DCLK2 isoform X11

UniProtKB/TrEMBL

A0A8L2QVM1
XM_063281895.1 → XP_063137965.1 serine/threonine-protein kinase DCLK2 isoform X7

UniProtKB/TrEMBL

A0A8L2QVM1

Related

ENSRNOP00000111349.1, ENSRNOT00000134768.1
XM_063281901.1 → XP_063137971.1 serine/threonine-protein kinase DCLK2 isoform X13

UniProtKB/TrEMBL

A0A8L2QQT4