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    Cd33 CD33 molecule [ Rattus norvegicus (Norway rat) ]

    Gene ID: 690492, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Cd33provided by RGD
    Official Full Name
    CD33 moleculeprovided by RGD
    Primary source
    RGD:1596020
    See related
    EnsemblRapid:ENSRNOG00000037331 AllianceGenome:RGD:1596020
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable protein phosphatase binding activity; protein tyrosine phosphatase activator activity; and sialic acid binding activity. Predicted to be involved in several processes, including immune response-regulating signaling pathway; negative regulation of cytokine production; and negative regulation of monocyte activation. Predicted to be located in several cellular components, including Golgi apparatus; external side of plasma membrane; and peroxisome. Predicted to be active in plasma membrane. Orthologous to several human genes including CD33 (CD33 molecule). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Spleen (RPKM 39.3), Lung (RPKM 36.3) and 9 other tissues See more
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    Genomic context

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    See Cd33 in Genome Data Viewer
    Location:
    1q22
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (103071985..103086687, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (93935418..93940452, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (98388811..98403539)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC130062809 Neighboring gene SIGLEC family like 1 Neighboring gene zinc finger protein 658 Neighboring gene zinc finger protein 719

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The Alzheimer's disease-protective CD33 splice variant mediates adaptive loss of function via diversion to an intracellular pool. Siddiqui SS, et al. J Biol Chem, 2017 Sep 15. PMID 28747436, Free PMC Article
    2. Epitope mapping, expression and post-translational modifications of two isoforms of CD33 (CD33M and CD33m) on lymphoid and myeloid human cells. Pérez-Oliva AB, et al. Glycobiology, 2011 Jun. PMID 21278227
    3. Constitutive repressor activity of CD33 on human monocytes requires sialic acid recognition and phosphoinositide 3-kinase-mediated intracellular signaling. Lajaunias F, et al. Eur J Immunol, 2005 Jan. PMID 15597323
    4. Characterization of CD33 as a new member of the sialoadhesin family of cellular interaction molecules. Freeman SD, et al. Blood, 1995 Apr 15. PMID 7718872
    5. Myeloid specific human CD33 is an inhibitory receptor with differential ITIM function in recruiting the phosphatases SHP-1 and SHP-2. Paul SP, et al. Blood, 2000 Jul 15. PMID 10887109

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables carbohydrate binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein phosphatase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein tyrosine phosphatase activator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables sialic acid binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables sialic acid binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in Fc-gamma receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cell adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell-cell adhesion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in immune response-inhibiting signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of interleukin-1 beta production ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of interleukin-8 production ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of monocyte activation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of tumor necrosis factor production ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of protein secretion ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in external side of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in peroxisome ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    CD33 molecule; myeloid cell surface antigen CD33

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001432624.1 → NP_001419553.1  CD33 molecule isoform a precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/TrEMBL
      A0A8I6GJX8, A6JAI4

    2. NM_001432625.1 → NP_001419554.1  CD33 molecule isoform a precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/TrEMBL
      A0A8I6GJX8, A6JAI4

    3. NM_001432626.1 → NP_001419555.1  CD33 molecule isoform b precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/TrEMBL
      F1LTZ3

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      103071985..103086687 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063280940.1 → XP_063137010.1  myeloid cell surface antigen CD33 isoform X1

      Related
      ENSRNOP00000050122.5, ENSRNOT00000047473.5

    2. XM_017590101.3 → XP_017445590.1  myeloid cell surface antigen CD33 isoform X1

      Conserved Domains (3) summary
      smart00410
      Location:26 → 119
      IG_like; Immunoglobulin like
      pfam13927
      Location:144 → 215
      Ig_3; Immunoglobulin domain
      cl11960
      Location:21 → 139
      Ig; Immunoglobulin domain

    3. XM_063280941.1 → XP_063137011.1  myeloid cell surface antigen CD33 isoform X2

    4. XM_017590104.3 → XP_017445593.1  myeloid cell surface antigen CD33 isoform X3

    5. XM_039100905.2 → XP_038956833.1  myeloid cell surface antigen CD33 isoform X4

    RNA

    1. XR_005499032.2 RNA Sequence

    2. XR_005499030.2 RNA Sequence

    3. XR_005499031.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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