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    Igf1r insulin-like growth factor 1 receptor [ Rattus norvegicus (Norway rat) ]

    Gene ID: 25718, updated on 9-Dec-2024

    Summary

    Official Symbol
    Igf1rprovided by RGD
    Official Full Name
    insulin-like growth factor 1 receptorprovided by RGD
    Primary source
    RGD:2869
    See related
    EnsemblRapid:ENSRNOG00000014187 AllianceGenome:RGD:2869
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Igfr1; JTK13; IGFIRC; IGF-1 receptor
    Summary
    Enables G-protein alpha-subunit binding activity; insulin receptor substrate binding activity; and insulin-like growth factor receptor activity. Involved in several processes, including cellular response to ketone; cellular response to peptide hormone stimulus; and negative regulation of apoptotic process. Located in several cellular components, including T-tubule; caveola; and neuronal cell body. Used to study Alzheimer's disease; Parkinson's disease; and prostate adenocarcinoma. Biomarker of several diseases, including alcoholic neuropathy; artery disease (multiple); carcinoma (multiple); diabetes mellitus (multiple); and neurodegenerative disease (multiple). Human ortholog(s) of this gene implicated in several diseases, including IgA glomerulonephritis; dementia (multiple); kidney cancer (multiple); liver disease (multiple); and toxic encephalopathy. Orthologous to human IGF1R (insulin like growth factor 1 receptor). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Adrenal (RPKM 154.5), Kidney (RPKM 119.0) and 9 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Igf1r in Genome Data Viewer
    Location:
    1q22
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (130959787..131248664)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (121549831..121838548)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (128924921..129213816)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134484899 Neighboring gene thymosin beta 10 like 5 Neighboring gene uncharacterized LOC134483685 Neighboring gene pyroglutamyl-peptidase I-like Neighboring gene family with sequence similarity 169, member B Neighboring gene U4 spliceosomal RNA Neighboring gene uncharacterized LOC102551020 Neighboring gene uncharacterized LOC120099846

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by RGD

    Items 1 - 25 of 53
    Function Evidence Code Pubs
    enables ATP binding  
    enables G-protein alpha-subunit binding PubMed 
    enables GPI-linked ephrin receptor activity  
    enables boss receptor activity  
    enables brain-derived neurotrophic factor receptor activity  
    enables epidermal growth factor receptor activity  
    enables fibroblast growth factor receptor activity  
    enables hepatocyte growth factor receptor activity  
    enables histone H2AXY142 kinase activity  
    enables histone H3Y41 kinase activity  
    enables identical protein binding  
    enables identical protein binding  
    enables insulin binding  
    enables insulin binding  
    enables insulin receptor activity  
    enables insulin receptor activity  
    enables insulin receptor binding  
    enables insulin receptor binding  
    enables insulin receptor substrate binding  
    enables insulin receptor substrate binding  
    enables insulin receptor substrate binding PubMed 
    enables insulin receptor substrate binding  
    enables insulin receptor substrate binding  
    enables insulin-like growth factor I binding  
    enables insulin-like growth factor I binding  
    enables insulin-like growth factor binding  
    enables insulin-like growth factor binding  
    enables insulin-like growth factor binding PubMed 
    enables insulin-like growth factor receptor activity PubMed 
    enables insulin-like growth factor receptor activity  
    enables insulin-like growth factor receptor activity  
    enables insulin-like growth factor receptor activity  
    enables insulin-like growth factor receptor activity PubMed 
    enables macrophage colony-stimulating factor receptor activity  
    enables phosphatidylinositol 3-kinase binding  
    enables phosphatidylinositol 3-kinase binding  
    enables phosphatidylinositol 3-kinase binding  
    enables placental growth factor receptor activity  
    enables platelet-derived growth factor alpha-receptor activity  
    enables platelet-derived growth factor beta-receptor activity  
    enables protein binding PubMed 
    enables protein transporter activity  
    enables protein transporter activity  
    enables protein tyrosine kinase activity PubMed 
    enables protein tyrosine kinase activity  
    enables protein tyrosine kinase activity  
    enables protein tyrosine kinase collagen receptor activity  
    enables protein-containing complex binding PubMed 
    enables stem cell factor receptor activity  
    enables structural molecule activity  
    enables structural molecule activity  
    enables transmembrane-ephrin receptor activity  
    enables vascular endothelial growth factor receptor activity  
    Items 1 - 25 of 53
    Items 1 - 25 of 119
    Process Evidence Code Pubs
    involved_in Kit signaling pathway  
    acts_upstream_of MAPK cascade  
    involved_in adrenal gland development  
    involved_in amyloid-beta clearance  
    involved_in amyloid-beta clearance  
    acts_upstream_of_or_within animal organ morphogenesis  
    involved_in axonogenesis PubMed 
    acts_upstream_of_or_within brain development  
    involved_in brain-derived neurotrophic factor receptor signaling pathway  
    involved_in cardiac atrium development PubMed 
    involved_in cellular response to aldosterone PubMed 
    involved_in cellular response to amyloid-beta  
    involved_in cellular response to amyloid-beta  
    involved_in cellular response to angiotensin PubMed 
    involved_in cellular response to dexamethasone stimulus PubMed 
    involved_in cellular response to estradiol stimulus PubMed 
    involved_in cellular response to glucose stimulus  
    involved_in cellular response to glucose stimulus PubMed 
    acts_upstream_of_or_within cellular response to glucose stimulus  
    involved_in cellular response to insulin stimulus PubMed 
    acts_upstream_of_or_within cellular response to insulin stimulus  
    involved_in cellular response to insulin-like growth factor stimulus PubMed 
    involved_in cellular response to insulin-like growth factor stimulus PubMed 
    involved_in cellular response to mechanical stimulus PubMed 
    involved_in cellular response to progesterone stimulus PubMed 
    involved_in cellular response to testosterone stimulus PubMed 
    involved_in cellular response to transforming growth factor beta stimulus PubMed 
    involved_in cellular response to zinc ion starvation PubMed 
    involved_in cellular senescence PubMed 
    involved_in cerebellum development PubMed 
    involved_in cerebellum development PubMed 
    involved_in chromatin remodeling  
    involved_in collagen-activated tyrosine kinase receptor signaling pathway  
    involved_in dendritic spine maintenance PubMed 
    involved_in ephrin receptor signaling pathway  
    involved_in epidermal growth factor receptor signaling pathway  
    acts_upstream_of_or_within epidermis development  
    involved_in establishment of cell polarity PubMed 
    involved_in estrous cycle PubMed 
    acts_upstream_of_or_within exocrine pancreas development  
    involved_in fibroblast growth factor receptor signaling pathway  
    involved_in hepatocyte growth factor receptor signaling pathway  
    involved_in hippocampus development PubMed 
    involved_in immune response  
    involved_in immune response  
    involved_in insulin receptor signaling pathway  
    involved_in insulin receptor signaling pathway PubMed 
    involved_in insulin-like growth factor receptor signaling pathway  
    involved_in insulin-like growth factor receptor signaling pathway  
    involved_in insulin-like growth factor receptor signaling pathway  
    involved_in insulin-like growth factor receptor signaling pathway  
    involved_in macrophage colony-stimulating factor signaling pathway  
    acts_upstream_of_or_within male sex determination  
    acts_upstream_of_or_within mammary gland development  
    acts_upstream_of mitotic nuclear division  
    involved_in multicellular organism development  
    acts_upstream_of_or_within negative regulation of DNA-binding transcription factor activity  
    involved_in negative regulation of MAPK cascade  
    acts_upstream_of_or_within negative regulation of MAPK cascade  
    involved_in negative regulation of MAPK cascade  
    involved_in negative regulation of MAPK cascade  
    involved_in negative regulation of apoptotic process  
    involved_in negative regulation of apoptotic process  
    involved_in negative regulation of apoptotic process  
    involved_in negative regulation of cholangiocyte apoptotic process PubMed 
    involved_in negative regulation of hepatocyte apoptotic process PubMed 
    involved_in negative regulation of muscle cell apoptotic process PubMed 
    acts_upstream_of_or_within negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  
    involved_in neuron projection development PubMed 
    acts_upstream_of_or_within peptidyl-tyrosine autophosphorylation  
    acts_upstream_of phosphatidylinositol 3-kinase/protein kinase B signal transduction  
    involved_in platelet-derived growth factor receptor-alpha signaling pathway  
    involved_in platelet-derived growth factor receptor-beta signaling pathway  
    involved_in positive regulation of DNA metabolic process PubMed 
    involved_in positive regulation of DNA-templated transcription  
    involved_in positive regulation of MAPK cascade  
    acts_upstream_of_or_within positive regulation of MAPK cascade  
    involved_in positive regulation of axon regeneration PubMed 
    involved_in positive regulation of cell migration  
    involved_in positive regulation of cell migration  
    involved_in positive regulation of cell population proliferation  
    involved_in positive regulation of cell population proliferation  
    involved_in positive regulation of cold-induced thermogenesis  
    involved_in positive regulation of cold-induced thermogenesis PubMed 
    involved_in positive regulation of cytokinesis PubMed 
    involved_in positive regulation of developmental growth  
    involved_in positive regulation of meiotic cell cycle  
    acts_upstream_of_or_within positive regulation of mitotic nuclear division  
    involved_in positive regulation of osteoblast proliferation PubMed 
    involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  
    involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  
    involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction PubMed 
    acts_upstream_of_or_within positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  
    involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  
    involved_in positive regulation of protein-containing complex disassembly PubMed 
    involved_in positive regulation of smooth muscle cell proliferation PubMed 
    involved_in positive regulation of steroid hormone biosynthetic process PubMed 
    involved_in postsynaptic modulation of chemical synaptic transmission  
    acts_upstream_of_or_within prostate gland epithelium morphogenesis  
    involved_in protein autophosphorylation  
    involved_in protein autophosphorylation  
    acts_upstream_of_or_within protein phosphorylation  
    involved_in regulation of JNK cascade  
    involved_in regulation of JNK cascade  
    involved_in regulation of JNK cascade  
    involved_in regulation of JNK cascade  
    involved_in response to L-glutamate PubMed 
    involved_in response to alkaloid PubMed 
    involved_in response to ethanol PubMed 
    involved_in response to ethanol PubMed 
    involved_in response to hormone PubMed 
    involved_in response to insulin PubMed 
    involved_in response to nicotine PubMed 
    involved_in response to nutrient levels PubMed 
    involved_in response to vitamin E PubMed 
    involved_in transcytosis  
    involved_in transcytosis  
    involved_in vascular endothelial growth factor receptor-1 signaling pathway  
    involved_in vascular endothelial growth factor signaling pathway  
    Items 1 - 25 of 119
    Component Evidence Code Pubs
    located_in T-tubule PubMed 
    located_in T-tubule  
    part_of alphav-beta3 integrin-IGF-1-IGF1R complex  
    part_of alphav-beta3 integrin-IGF-1-IGF1R complex  
    is_active_in axon  
    located_in axon PubMed 
    located_in caveola PubMed 
    is_active_in glutamatergic synapse  
    part_of insulin receptor complex  
    located_in intracellular membrane-bounded organelle  
    located_in intracellular membrane-bounded organelle  
    located_in membrane  
    located_in neuronal cell body PubMed 
    is_active_in plasma membrane  
    located_in plasma membrane  
    part_of protein kinase complex  
    part_of protein kinase complex  
    part_of receptor complex  
    part_of receptor complex  

    General protein information

    Preferred Names
    insulin-like growth factor 1 receptor
    Names
    IGF-I receptor
    insulin-like growth factor I receptor
    type-I IGF receptor
    NP_001401110.1
    NP_434694.1
    XP_008757722.1
    XP_038958145.1
    XP_038958153.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001414181.1NP_001401110.1  insulin-like growth factor 1 receptor isoform 1 precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/TrEMBL
      A0A140TAB8
      Related
      ENSRNOP00000019267.8, ENSRNOT00000019267.8
    2. NM_052807.3NP_434694.1  insulin-like growth factor 1 receptor isoform 2 precursor

      See identical proteins and their annotated locations for NP_434694.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/Swiss-Prot
      P24062
      UniProtKB/TrEMBL
      A0A140TAB8
      Conserved Domains (7) summary
      cd05032
      Location:9931269
      PTKc_InsR_like; Catalytic domain of Insulin Receptor-like Protein Tyrosine Kinases
      cd00063
      Location:836925
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00064
      Location:230277
      FU; Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.
      pfam00757
      Location:175330
      Furin-like; Furin-like cysteine rich region
      pfam01030
      Location:353467
      Recep_L_domain; Receptor L domain
      pfam07714
      Location:10001264
      Pkinase_Tyr; Protein tyrosine kinase
      cl22855
      Location:207336
      TNFRSF; Tumor necrosis factor receptor superfamily (TNFRSF)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      130959787..131248664
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039102225.2XP_038958153.1  insulin-like growth factor 1 receptor isoform X3

      UniProtKB/TrEMBL
      A6JBU5
      Conserved Domains (3) summary
      cd00063
      Location:837926
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00757
      Location:175330
      Furin-like; Furin-like cysteine rich region
      pfam01030
      Location:353467
      Recep_L_domain; Receptor L domain
    2. XM_039102217.2XP_038958145.1  insulin-like growth factor 1 receptor isoform X2

      UniProtKB/TrEMBL
      A0A140TAB8
      Conserved Domains (4) summary
      cd05032
      Location:9941270
      PTKc_InsR_like; Catalytic domain of Insulin Receptor-like Protein Tyrosine Kinases
      cd00063
      Location:837926
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00757
      Location:175330
      Furin-like; Furin-like cysteine rich region
      pfam01030
      Location:353467
      Recep_L_domain; Receptor L domain
    3. XM_008759500.3XP_008757722.1  insulin-like growth factor 1 receptor isoform X1

      UniProtKB/TrEMBL
      A0A140TAB8
      Related
      ENSRNOP00000106862.1, ENSRNOT00000096947.2
      Conserved Domains (7) summary
      cd05032
      Location:9941271
      PTKc_InsR_like; Catalytic domain of Insulin Receptor-like Protein Tyrosine Kinases
      cd00063
      Location:837926
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00064
      Location:230277
      FU; Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.
      pfam00757
      Location:175330
      Furin-like; Furin-like cysteine rich region
      pfam01030
      Location:353467
      Recep_L_domain; Receptor L domain
      pfam07714
      Location:10011266
      Pkinase_Tyr; Protein tyrosine kinase
      cl22855
      Location:207336
      TNFRSF; Tumor necrosis factor receptor superfamily (TNFRSF)
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