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    Slc6a18 solute carrier family 6 member 18 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 29323, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Slc6a18provided by RGD
    Official Full Name
    solute carrier family 6 member 18provided by RGD
    Primary source
    RGD:69352
    See related
    EnsemblRapid:ENSRNOG00000016253 AllianceGenome:RGD:69352
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Rosit; Xtrp2
    Summary
    Predicted to enable neutral L-amino acid:sodium:chloride symporter activity. Involved in hyperosmotic response. Predicted to be located in apical plasma membrane and brush border membrane. Predicted to be active in plasma membrane. Orthologous to human SLC6A18 (solute carrier family 6 member 18). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward (RPKM 1187.2) See more
    Orthologs
    human mouse all
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    Genomic context

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    See Slc6a18 in Genome Data Viewer
    Location:
    1p11
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (31436577..31450478)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (29607288..29621925)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (32221679..32235599)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene solute carrier family 12 member 7 Neighboring gene solute carrier family 6 member 19 Neighboring gene RNA polymerase II transcriptional coactivator-like Neighboring gene telomerase reverse transcriptase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Gene regulation of renal-osmotic stress-induced Na-CL organic solute cotransporter. Baba T, et al. Nephron Exp Nephrol, 2004. PMID 15056985
    2. Molecular characterization of ROSIT, a renal osmotic stress-induced Na(+)-Cl(-)-organic solute cotransporter. Wasserman JC, et al. Am J Physiol, 1994 Oct. PMID 7943364
    3. Molecular basis for the interaction of the mammalian amino acid transporters B0AT1 and B0AT3 with their ancillary protein collectrin. Fairweather SJ, et al. J Biol Chem, 2015 Oct 2. PMID 26240152, Free PMC Article
    4. Orphan transporter SLC6A18 is renal neutral amino acid transporter B0AT3. Singer D, et al. J Biol Chem, 2009 Jul 24. PMID 19478081, Free PMC Article
    5. Essential role for collectrin in renal amino acid transport. Danilczyk U, et al. Nature, 2006 Dec 21. PMID 17167413

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Regulation of ROSIT mRNA levels in nephrons.
      Title: Gene regulation of renal-osmotic stress-induced Na-CL organic solute cotransporter.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC93507

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    NOT contributes_to amino acid transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables neutral L-amino acid transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables neutral L-amino acid:sodium:chloride symporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables neutral L-amino acid:sodium:chloride symporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables neutral L-amino acid:sodium:chloride symporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables symporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in amino acid transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within amino acid transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in amino acid transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    NOT involved_in amino acid transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in hyperosmotic response IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in hyperosmotic response NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in neurotransmitter transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in neutral amino acid transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in neutral amino acid transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in neutral amino acid transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in renal amino acid absorption IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in renal amino acid absorption ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in renal amino acid absorption ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in sodium ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in apical plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in apical plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in apical plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in brush border membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in brush border membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    sodium-dependent neutral amino acid transporter B(0)AT3
    Names
    X transporter protein 2
    b(0)AT3
    renal osmotic stress-induced Na-Cl organic solute cotransporter
    sodium- and chloride-dependent transporter XTRP2
    solute carrier family 6 (neurotransmitter transporter), member 18
    solute carrier family 6 (neutral amino acid transporter), member 18
    system B(0) neutral amino acid transporter AT3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_017163.2 → NP_058859.2  sodium-dependent neutral amino acid transporter B(0)AT3

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/Swiss-Prot
      Q62687
      UniProtKB/TrEMBL
      A6JUW9, G3V847
      Related
      ENSRNOP00000022346.1, ENSRNOT00000022346.5
      Conserved Domains (1) summary
      cd11517
      Location:16 → 591
      SLC6sbd_B0AT3; glycine transporter, B0AT3; solute-binding domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      31436577..31450478
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063285328.1 → XP_063141398.1  sodium-dependent neutral amino acid transporter B(0)AT3 isoform X1

      UniProtKB/Swiss-Prot
      Q62687

    2. XM_006227772.4 → XP_006227834.1  sodium-dependent neutral amino acid transporter B(0)AT3 isoform X4

      See identical proteins and their annotated locations for XP_006227834.1

      UniProtKB/Swiss-Prot
      Q62687
      UniProtKB/TrEMBL
      A0A8I5ZTR9, A6JUX1
      Related
      ENSRNOP00000082226.1, ENSRNOT00000113926.2
      Conserved Domains (1) summary
      cl00456
      Location:16 → 498
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

    3. XM_006227774.4 → XP_006227836.1  sodium-dependent neutral amino acid transporter B(0)AT3 isoform X6

      UniProtKB/TrEMBL
      A0A8I6AA48, A6JUX0
      Related
      ENSRNOP00000088766.1, ENSRNOT00000096395.2
      Conserved Domains (1) summary
      cl00456
      Location:16 → 553
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

    4. XM_006227775.5 → XP_006227837.1  sodium-dependent neutral amino acid transporter B(0)AT3 isoform X7

      See identical proteins and their annotated locations for XP_006227837.1

      UniProtKB/TrEMBL
      A6JUX2
      Conserved Domains (1) summary
      cl00456
      Location:16 → 460
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

    5. XM_063285333.1 → XP_063141403.1  sodium-dependent neutral amino acid transporter B(0)AT3 isoform X3

      UniProtKB/Swiss-Prot
      Q62687

    6. XM_039106581.2 → XP_038962509.1  sodium-dependent neutral amino acid transporter B(0)AT3 isoform X5

      UniProtKB/TrEMBL
      Q5XIV7
      Related
      ENSRNOP00000072758.1, ENSRNOT00000089941.3
      Conserved Domains (1) summary
      cl00456
      Location:16 → 455
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

    7. XM_063285332.1 → XP_063141402.1  sodium-dependent neutral amino acid transporter B(0)AT3 isoform X2

      UniProtKB/Swiss-Prot
      Q62687
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q62687.1 GenPept UniProtKB/Swiss-Prot:Q62687

    Gene LinkOut

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