Asmt acetylserotonin O-methyltransferase [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Asmtprovided by RGD
Official Full Name: acetylserotonin O-methyltransferaseprovided by RGD
Primary source: RGD:708472
See related: EnsemblRapid:ENSRNOG00000001324 AllianceGenome:RGD:708472
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables acetylserotonin O-methyltransferase activity. Involved in melatonin biosynthetic process. Orthologous to human ASMT (acetylserotonin O-methyltransferase). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Brain (RPKM 5.0), Kidney (RPKM 4.4) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 12q11

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	12	NC_086030.1 (21418477..21423336, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	12	NC_051347.1 (16304719..16309568, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	12	NC_005111.4 (18521383..18527036, complement)

Chromosome 12 - NC_086030.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Effects of acute hypothyroidism on plasma melatonin and Aanat and Asmt expression in the pineal gland and gonads of rats.
Title: Effects of acute hypothyroidism on plasma melatonin and Aanat and Asmt expression in the pineal gland and gonads of rats.
The testes of control animals express the Tph1, Aanat, and Asmt and Per2 genes with 24-h rhythms in mRNA, reaching the maximal values during the dark phase.
Title: The Absence of Pineal Melatonin Abolishes the Daily Rhythm of Tph1 (Tryptophan Hydroxylase 1), Asmt (Acetylserotonin O-Methyltransferase), and Aanat (Aralkylamine N-Acetyltransferase) mRNA Expressions in Rat Testes.
The expression of HIOMT in epithelial cells of striated ducts in rat submandibular glands.
Title: Expression and cellular localizaion of melatonin-synthesizing enzymes in rat and human salivary glands.

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General gene information

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Markers

RH131804 (e-PCR)
- UniSTS:215087

RH130065 (e-PCR)
- UniSTS:213353

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables S-adenosylmethionine-dependent methyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables acetylserotonin O-methyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables acetylserotonin O-methyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables acetylserotonin O-methyltransferase activity	IEA Inferred from Electronic Annotation more info
enables acetylserotonin O-methyltransferase activity	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in lipid metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of male gonad development	ISO Inferred from Sequence Orthology more info
involved_in melatonin biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in melatonin biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in melatonin biosynthetic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within melatonin biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in melatonin biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in methylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in methylation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of male gonad development	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: acetylserotonin O-methyltransferase

Names: hydroxyindole O-methyltransferase

NP_653360.2

EC 2.1.1.4

XP_063127116.1

EC 2.1.1.4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.