U.S. flag

An official website of the United States government

Links from GEO Profiles

    • Showing Current items.

    Lepr leptin receptor [ Rattus norvegicus (Norway rat) ]

    Gene ID: 24536, updated on 9-Dec-2024

    Summary

    Official Symbol
    Leprprovided by RGD
    Official Full Name
    leptin receptorprovided by RGD
    Primary source
    RGD:3001
    See related
    EnsemblRapid:ENSRNOG00000023664 AllianceGenome:RGD:3001
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Fa
    Summary
    Enables peptide hormone binding activity and protein-hormone receptor activity. Involved in several processes, including gonad development; negative regulation of behavior; and positive regulation of cell communication. Located in extracellular space. Used to study several diseases, including chronic kidney disease; congestive heart failure (multiple); glucose metabolism disease (multiple); obesity; and renal fibrosis. Biomarker of pre-eclampsia and short bowel syndrome. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); liver disease (multiple); obesity; obstructive sleep apnea; and type 2 diabetes mellitus. Orthologous to human LEPR (leptin receptor). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Spleen (RPKM 91.8), Liver (RPKM 83.9) and 9 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Lepr in Genome Data Viewer
    Location:
    5q33
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (121409735..121593201)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (116294409..116477904)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (120503475..120682281)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene DnaJ heat shock protein family (Hsp40) member C6 Neighboring gene uncharacterized LOC134479018 Neighboring gene uncharacterized LOC120102936 Neighboring gene leptin receptor overlapping transcript Neighboring gene oogenesin 3, pseudogene 1 Neighboring gene PRAME family member 12, pseudogene 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables cytokine binding  
    enables cytokine receptor activity  
    enables cytokine receptor activity  
    enables identical protein binding  
    enables leptin receptor activity  
    enables leptin receptor activity  
    enables leptin receptor activity  
    enables peptide hormone binding PubMed 
    enables peptide hormone binding PubMed 
    enables protein-hormone receptor activity PubMed 
    enables protein-hormone receptor activity PubMed 
    Items 1 - 25 of 73
    Process Evidence Code Pubs
    involved_in T cell differentiation  
    involved_in T cell differentiation  
    involved_in T cell differentiation  
    involved_in angiogenesis  
    involved_in angiogenesis PubMed 
    involved_in angiogenesis  
    involved_in angiogenesis  
    involved_in bone growth  
    involved_in bone growth  
    involved_in bone growth  
    involved_in cellular response to acetate PubMed 
    involved_in cellular response to butyrate PubMed 
    involved_in cholesterol metabolic process  
    acts_upstream_of_or_within cholesterol metabolic process  
    involved_in cytokine-mediated signaling pathway  
    involved_in cytokine-mediated signaling pathway  
    involved_in eating behavior PubMed 
    involved_in energy homeostasis  
    involved_in energy homeostasis  
    involved_in energy homeostasis  
    involved_in female pregnancy PubMed 
    involved_in generation of precursor metabolites and energy PubMed 
    involved_in glial cell proliferation  
    acts_upstream_of_or_within glial cell proliferation  
    involved_in gluconeogenesis  
    acts_upstream_of gluconeogenesis  
    involved_in glucose homeostasis  
    involved_in glucose homeostasis  
    involved_in glucose homeostasis  
    involved_in glycogen metabolic process  
    acts_upstream_of_or_within glycogen metabolic process  
    involved_in leptin-mediated signaling pathway PubMed 
    involved_in leptin-mediated signaling pathway  
    involved_in leptin-mediated signaling pathway  
    involved_in male gonad development PubMed 
    involved_in negative regulation of autophagy  
    involved_in negative regulation of autophagy  
    involved_in negative regulation of autophagy  
    involved_in negative regulation of eating behavior PubMed 
    involved_in negative regulation of gluconeogenesis  
    acts_upstream_of_or_within negative regulation of gluconeogenesis  
    acts_upstream_of_or_within negative regulation of hydrolase activity  
    involved_in negative regulation of locomotor rhythm PubMed 
    involved_in ovulation from ovarian follicle PubMed 
    involved_in phagocytosis  
    involved_in phagocytosis  
    involved_in phagocytosis  
    involved_in positive regulation of MAPK cascade PubMed 
    involved_in positive regulation of cell population proliferation  
    involved_in positive regulation of cold-induced thermogenesis  
    involved_in positive regulation of cold-induced thermogenesis  
    involved_in positive regulation of cold-induced thermogenesis PubMed 
    involved_in positive regulation of insulin secretion involved in cellular response to glucose stimulus PubMed 
    involved_in positive regulation of protein phosphorylation  
    involved_in regulation of bone remodeling  
    involved_in regulation of bone remodeling  
    involved_in regulation of bone remodeling  
    involved_in regulation of feeding behavior  
    involved_in regulation of feeding behavior  
    involved_in regulation of feeding behavior  
    involved_in regulation of transport  
    involved_in regulation of transport  
    involved_in response to dexamethasone PubMed 
    involved_in response to estrogen PubMed 
    involved_in response to hypoxia PubMed 
    involved_in response to leptin PubMed 
    involved_in response to leptin  
    involved_in response to lipid PubMed 
    involved_in response to nicotine PubMed 
    involved_in response to nutrient PubMed 
    involved_in sexual reproduction  
    involved_in sexual reproduction  
    involved_in sexual reproduction  
    Items 1 - 25 of 73
    Component Evidence Code Pubs
    located_in basolateral plasma membrane  
    is_active_in external side of plasma membrane  
    located_in extracellular space PubMed 
    part_of receptor complex  
    part_of receptor complex  
    part_of receptor complex  

    General protein information

    Preferred Names
    leptin receptor
    Names
    LEP-R
    Leptin receptor (fatty)
    OB receptor
    OB-R

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001429454.1 → NP_001416383.1  leptin receptor isoform 1 precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/TrEMBL
      A0A8I5ZQD9, A6JRP2
    2. NM_001429459.1 → NP_001416388.1  leptin receptor isoform 2 precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/TrEMBL
      A6JRP8, F1M9F2
    3. NM_001429460.1 → NP_001416389.1  leptin receptor isoform 2 precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/TrEMBL
      A6JRP8, F1M9F2
    4. NM_001429461.1 → NP_001416390.1  leptin receptor isoform 3 precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/TrEMBL
      A0A8I6AJP1, A6JRP6
    5. NM_001429462.1 → NP_001416391.1  leptin receptor isoform 3 precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/TrEMBL
      A0A8I6AJP1, A6JRP6
    6. NM_012596.3 → NP_036728.2  leptin receptor isoform 1 precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/TrEMBL
      A0A8I5ZQD9, A6JRP2
      Related
      ENSRNOP00000080721.1, ENSRNOT00000044131.9
      Conserved Domains (4) summary
      smart00060
      Location:738 → 818
      FN3; Fibronectin type 3 domain
      cd00063
      Location:236 → 328
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam06328
      Location:327 → 418
      Lep_receptor_Ig; Ig-like C2-type domain
      pfam18589
      Location:429 → 531
      ObR_Ig; Obesity receptor immunoglobulin like domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      121409735..121593201
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039109265.2 → XP_038965193.1  leptin receptor isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZQD9, A6JRP2
      Conserved Domains (4) summary
      smart00060
      Location:738 → 818
      FN3; Fibronectin type 3 domain
      cd00063
      Location:236 → 328
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam06328
      Location:327 → 418
      Lep_receptor_Ig; Ig-like C2-type domain
      pfam18589
      Location:429 → 531
      ObR_Ig; Obesity receptor immunoglobulin like domain
    2. XM_039109264.2 → XP_038965192.1  leptin receptor isoform X1

      Conserved Domains (4) summary
      smart00060
      Location:738 → 818
      FN3; Fibronectin type 3 domain
      cd00063
      Location:236 → 328
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam06328
      Location:327 → 418
      Lep_receptor_Ig; Ig-like C2-type domain
      pfam18589
      Location:429 → 531
      ObR_Ig; Obesity receptor immunoglobulin like domain
    3. XM_039109267.2 → XP_038965195.1  leptin receptor isoform X3

      Related
      ENSRNOP00000093122.1, ENSRNOT00000093574.3
      Conserved Domains (4) summary
      smart00060
      Location:738 → 818
      FN3; Fibronectin type 3 domain
      cd00063
      Location:236 → 328
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam06328
      Location:327 → 418
      Lep_receptor_Ig; Ig-like C2-type domain
      pfam18589
      Location:429 → 531
      ObR_Ig; Obesity receptor immunoglobulin like domain
    4. XM_063287158.1 → XP_063143228.1  leptin receptor isoform X3

    5. XM_063287157.1 → XP_063143227.1  leptin receptor isoform X2

    6. XM_039109266.2 → XP_038965194.1  leptin receptor isoform X2

      Related
      ENSRNOP00000045398.5, ENSRNOT00000050597.7
      Conserved Domains (4) summary
      smart00060
      Location:738 → 818
      FN3; Fibronectin type 3 domain
      cd00063
      Location:236 → 328
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam06328
      Location:327 → 418
      Lep_receptor_Ig; Ig-like C2-type domain
      pfam18589
      Location:429 → 531
      ObR_Ig; Obesity receptor immunoglobulin like domain
    External link. Please review our privacy policy.