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    Rnf111 ring finger protein 111 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 300813, updated on 9-Dec-2024

    Summary

    Official Symbol
    Rnf111provided by RGD
    Official Full Name
    ring finger protein 111provided by RGD
    Primary source
    RGD:1310097
    See related
    EnsemblRapid:ENSRNOG00000060750 AllianceGenome:RGD:1310097
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables SMAD binding activity. Predicted to be involved in positive regulation of transforming growth factor beta receptor signaling pathway; protein ubiquitination; and ubiquitin-dependent protein catabolic process. Predicted to act upstream of or within pattern specification process; positive regulation of protein ubiquitination; and protein polyubiquitination. Predicted to be located in cytosol and nucleoplasm. Predicted to be part of protein-containing complex. Predicted to be active in cytoplasm and nucleus. Orthologous to human RNF111 (ring finger protein 111). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Spleen (RPKM 117.8), Thymus (RPKM 112.2) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Rnf111 in Genome Data Viewer
    Location:
    8q24
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (79984831..80061022, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (71103967..71180172, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (76864343..76940235, complement)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene myosin IE Neighboring gene U6 spliceosomal RNA Neighboring gene cyclin B2 Neighboring gene RNA polymerase II, I and III subunit K, pseudogene 1 Neighboring gene small nucleolar RNA, H/ACA box 20 Neighboring gene U6 spliceosomal RNA Neighboring gene SAFB-like, transcription modulator

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    Interactions

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables SMAD binding  
    enables SMAD binding PubMed 
    enables SUMO polymer binding  
    enables SUMO polymer binding  
    enables metal ion binding  
    enables ubiquitin protein ligase activity  
    enables ubiquitin protein ligase activity  
    Component Evidence Code Pubs
    located_in PML body  
    is_active_in cytoplasm  
    located_in cytoplasm  
    located_in cytosol  
    located_in cytosol  
    located_in nucleoplasm  
    is_active_in nucleus  
    located_in nucleus  
    part_of protein-containing complex  

    General protein information

    Preferred Names
    E3 ubiquitin-protein ligase Arkadia
    Names
    ring finger 111
    NP_001100306.1
    XP_006243434.1
    XP_006243435.1
    XP_006243436.1
    XP_038937059.1
    XP_038937060.1
    XP_038937061.1
    XP_038937063.1
    XP_038937064.1
    XP_038937065.1
    XP_063121238.1
    XP_063121240.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001106836.2 → NP_001100306.1  E3 ubiquitin-protein ligase Arkadia

      See identical proteins and their annotated locations for NP_001100306.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/TrEMBL
      A6KET4, D4A9T1
      Related
      ENSRNOP00000069810.3, ENSRNOT00000084313.3
      Conserved Domains (2) summary
      pfam13639
      Location:935 → 976
      zf-RING_2; Ring finger domain
      pfam15303
      Location:18 → 247
      RNF111_N; E3 ubiquitin-protein ligase Arkadia N-terminus

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      79984831..80061022 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039081137.2 → XP_038937065.1  E3 ubiquitin-protein ligase Arkadia isoform X8

      UniProtKB/TrEMBL
      D4A9T1
      Conserved Domains (3) summary
      cd16474
      Location:943 → 987
      RING-H2_RNF111_like; RING finger, H2 subclass, found in RING finger proteins RNF111, RNF165, and similar proteins
      pfam08192
      Location:276 → 427
      Peptidase_S64; Peptidase family S64
      pfam15303
      Location:18 → 247
      RNF111_N; E3 ubiquitin-protein ligase Arkadia N-terminus
    2. XM_039081135.2 → XP_038937063.1  E3 ubiquitin-protein ligase Arkadia isoform X8

      UniProtKB/TrEMBL
      D4A9T1
      Conserved Domains (3) summary
      cd16474
      Location:943 → 987
      RING-H2_RNF111_like; RING finger, H2 subclass, found in RING finger proteins RNF111, RNF165, and similar proteins
      pfam08192
      Location:276 → 427
      Peptidase_S64; Peptidase family S64
      pfam15303
      Location:18 → 247
      RNF111_N; E3 ubiquitin-protein ligase Arkadia N-terminus
    3. XM_039081132.2 → XP_038937060.1  E3 ubiquitin-protein ligase Arkadia isoform X2

      UniProtKB/TrEMBL
      D4A9T1
      Conserved Domains (3) summary
      cd16474
      Location:1041 → 1085
      RING-H2_RNF111_like; RING finger, H2 subclass, found in RING finger proteins RNF111, RNF165, and similar proteins
      pfam08192
      Location:375 → 526
      Peptidase_S64; Peptidase family S64
      pfam15303
      Location:117 → 346
      RNF111_N; E3 ubiquitin-protein ligase Arkadia N-terminus
    4. XM_063265168.1 → XP_063121238.1  E3 ubiquitin-protein ligase Arkadia isoform X5

      UniProtKB/TrEMBL
      D4A9T1
    5. XM_039081133.2 → XP_038937061.1  E3 ubiquitin-protein ligase Arkadia isoform X3

      UniProtKB/TrEMBL
      D4A9T1
      Conserved Domains (3) summary
      cd16474
      Location:1034 → 1078
      RING-H2_RNF111_like; RING finger, H2 subclass, found in RING finger proteins RNF111, RNF165, and similar proteins
      pfam08192
      Location:375 → 526
      Peptidase_S64; Peptidase family S64
      pfam15303
      Location:117 → 346
      RNF111_N; E3 ubiquitin-protein ligase Arkadia N-terminus
    6. XM_039081131.2 → XP_038937059.1  E3 ubiquitin-protein ligase Arkadia isoform X1

      UniProtKB/TrEMBL
      D4A9T1
      Conserved Domains (3) summary
      cd16474
      Location:1042 → 1086
      RING-H2_RNF111_like; RING finger, H2 subclass, found in RING finger proteins RNF111, RNF165, and similar proteins
      pfam08192
      Location:375 → 526
      Peptidase_S64; Peptidase family S64
      pfam15303
      Location:117 → 346
      RNF111_N; E3 ubiquitin-protein ligase Arkadia N-terminus
    7. XM_006243374.5 → XP_006243436.1  E3 ubiquitin-protein ligase Arkadia isoform X7

      UniProtKB/TrEMBL
      D4A9T1
      Conserved Domains (2) summary
      pfam13639
      Location:1025 → 1066
      zf-RING_2; Ring finger domain
      pfam15303
      Location:117 → 346
      RNF111_N; E3 ubiquitin-protein ligase Arkadia N-terminus
    8. XM_006243373.5 → XP_006243435.1  E3 ubiquitin-protein ligase Arkadia isoform X6

      UniProtKB/TrEMBL
      D4A9T1
      Related
      ENSRNOP00000104173.1, ENSRNOT00000164250.1
      Conserved Domains (2) summary
      pfam13639
      Location:1026 → 1067
      zf-RING_2; Ring finger domain
      pfam15303
      Location:117 → 346
      RNF111_N; E3 ubiquitin-protein ligase Arkadia N-terminus
    9. XM_006243372.5 → XP_006243434.1  E3 ubiquitin-protein ligase Arkadia isoform X4

      UniProtKB/TrEMBL
      D4A9T1
      Conserved Domains (2) summary
      pfam13639
      Location:1034 → 1075
      zf-RING_2; Ring finger domain
      pfam15303
      Location:117 → 346
      RNF111_N; E3 ubiquitin-protein ligase Arkadia N-terminus
    10. XM_039081136.2 → XP_038937064.1  E3 ubiquitin-protein ligase Arkadia isoform X8

      UniProtKB/TrEMBL
      D4A9T1
      Conserved Domains (3) summary
      cd16474
      Location:943 → 987
      RING-H2_RNF111_like; RING finger, H2 subclass, found in RING finger proteins RNF111, RNF165, and similar proteins
      pfam08192
      Location:276 → 427
      Peptidase_S64; Peptidase family S64
      pfam15303
      Location:18 → 247
      RNF111_N; E3 ubiquitin-protein ligase Arkadia N-terminus
    11. XM_063265170.1 → XP_063121240.1  E3 ubiquitin-protein ligase Arkadia isoform X8

      UniProtKB/TrEMBL
      D4A9T1
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