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    Usp36 ubiquitin specific peptidase 36 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 303700, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Usp36provided by RGD
    Official Full Name
    ubiquitin specific peptidase 36provided by RGD
    Primary source
    RGD:1309937
    See related
    EnsemblRapid:ENSRNOG00000028255 AllianceGenome:RGD:1309937
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable K48-linked deubiquitinase activity; cysteine-type deubiquitinase activity; and histone H2B deubiquitinase activity. Predicted to be involved in several processes, including positive regulation of protein targeting to mitochondrion; protein stabilization; and regulation of macroautophagy. Predicted to be located in cytoplasm; nuclear speck; and nucleolus. Predicted to be active in cytosol and nucleus. Orthologous to human USP36 (ubiquitin specific peptidase 36). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Adrenal (RPKM 88.9), Heart (RPKM 75.8) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Usp36 in Genome Data Viewer
    Location:
    10q32.3
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (103995970..104027492, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (103497349..103528877, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (107292828..107324355, complement)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134480725 Neighboring gene cytohesin 1 Neighboring gene TIMP metallopeptidase inhibitor 2 Neighboring gene CEP295 N-terminal like Neighboring gene galectin 3 binding protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The ubiquitin-specific protease USP36 is a conserved histone H2B deubiquitinase. DeVine T, et al. Biochem Biophys Res Commun, 2018 Jan 15. PMID 29274341, Free PMC Article
    2. Loss of the deubiquitinase USP36 destabilizes the RNA helicase DHX33 and causes preimplantation lethality in mice. Fraile JM, et al. J Biol Chem, 2018 Feb 9. PMID 29273634, Free PMC Article
    3. The nucleolar ubiquitin-specific protease USP36 deubiquitinates and stabilizes c-Myc. Sun XX, et al. Proc Natl Acad Sci U S A, 2015 Mar 24. PMID 25775507, Free PMC Article
    4. Nucleolar structure and function are regulated by the deubiquitylating enzyme USP36. Endo A, et al. J Cell Sci, 2009 Mar 1. PMID 19208757
    5. The deubiquitinating enzyme USP36 controls selective autophagy activation by ubiquitinated proteins. Taillebourg E, et al. Autophagy, 2012 May 1. PMID 22622177

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. USP36 actions extend beyond TrkA because the presence of USP36 interferes with Nedd4-2-dependent Kv7.2/3 channel regulation.
      Title: Ubiquitin-specific Protease 36 (USP36) Controls Neuronal Precursor Cell-expressed Developmentally Down-regulated 4-2 (Nedd4-2) Actions over the Neurotrophin Receptor TrkA and Potassium Voltage-gated Channels 7.2/3 (Kv7.2/3).
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables K48-linked deubiquitinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables cysteine-type deubiquitinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cysteine-type deubiquitinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables histone H2B deubiquitinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in chromatin organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of macroautophagy ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in nucleolus organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of protein targeting to mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    involved_in protein deubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein stabilization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of mitophagy ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    involved_in regulation of protein stability IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of protein stability ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of rRNA processing ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nuclear speck IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear speck ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    ubiquitin carboxyl-terminal hydrolase 36
    Names
    ubiquitin specific protease 36
    NP_001100539.1
    XP_038942129.1
    XP_038942131.1
    XP_063125312.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107069.1 → NP_001100539.1  ubiquitin carboxyl-terminal hydrolase 36

      See identical proteins and their annotated locations for NP_001100539.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473948
      UniProtKB/TrEMBL
      A6HL46, D3ZNQ4
      Related
      ENSRNOP00000060530.2, ENSRNOT00000064450.5
      Conserved Domains (2) summary
      cd02661
      Location:121 → 421
      Peptidase_C19E; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      pfam00443
      Location:122 → 420
      UCH; Ubiquitin carboxyl-terminal hydrolase

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      103995970..104027492 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039086203.1 → XP_038942131.1  ubiquitin carboxyl-terminal hydrolase 36 isoform X1

      UniProtKB/TrEMBL
      A0A0G2K033
      Related
      ENSRNOP00000071284.2, ENSRNOT00000084055.3
      Conserved Domains (2) summary
      cd02661
      Location:121 → 421
      Peptidase_C19E; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      pfam05109
      Location:493 → 807
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)

    2. XM_039086201.1 → XP_038942129.1  ubiquitin carboxyl-terminal hydrolase 36 isoform X1

      UniProtKB/TrEMBL
      A0A0G2K033
      Conserved Domains (2) summary
      cd02661
      Location:121 → 421
      Peptidase_C19E; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      pfam05109
      Location:493 → 807
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)

    3. XM_063269242.1 → XP_063125312.1  ubiquitin carboxyl-terminal hydrolase 36 isoform X2

    Nucleotide Protein Strain
    Heading Accession and Version

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