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    Zrsr2 zinc finger (CCCH type), RNA binding motif and serine/arginine rich 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 302670, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Zrsr2provided by RGD
    Official Full Name
    zinc finger (CCCH type), RNA binding motif and serine/arginine rich 2provided by RGD
    Primary source
    RGD:1559763
    See related
    EnsemblRapid:ENSRNOG00000033176 AllianceGenome:RGD:1559763
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1559763
    Summary
    Predicted to enable identical protein binding activity and pre-mRNA 3'-splice site binding activity. Predicted to be involved in spliceosomal complex assembly. Predicted to be located in nucleolus. Predicted to be part of U12-type spliceosomal complex and U2AF complex. Human ortholog(s) of this gene implicated in acute myeloid leukemia and myelodysplastic syndrome. Orthologous to several human genes including ZRSR2 (zinc finger CCCH-type, RNA binding motif and serine/arginine rich 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 56.7), Thymus (RPKM 40.3) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Zrsr2 in Genome Data Viewer
    Location:
    Xq14
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) X NC_086039.1 (34179279..34201989)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) X NC_051356.1 (30547424..30571613)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (32304707..32327419)

    Chromosome X - NC_086039.1Genomic Context describing neighboring genes Neighboring gene U6 spliceosomal RNA Neighboring gene carbonic anhydrase 5B Neighboring gene adaptor related protein complex 1 subunit sigma 2 Neighboring gene uncharacterized LOC120099291

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. [Comparision of Mutational Spectrum between Elderly and Young Adults with Acute Myeloid Leukemia Based on Next Generation Sequencing]. Wang WM, et al. Zhongguo Shi Yan Xue Ye Xue Za Zhi, 2020 Feb. PMID 32027246
    2. Exploration of the role of gene mutations in myelodysplastic syndromes through a sequencing design involving a small number of target genes. Xu F, et al. Sci Rep, 2017 Feb 21. PMID 28220884, Free PMC Article
    3. Mutations affecting mRNA splicing define distinct clinical phenotypes and correlate with patient outcome in myelodysplastic syndromes. Damm F, et al. Blood, 2012 Apr 5. PMID 22343920
    4. Refractory macrocytic anemias in patients with clonal hematopoietic disorders and isolated mutations of the spliceosome gene ZRSR2. Fleischman RA, et al. Leuk Res, 2017 Oct. PMID 28942350
    5. The U2AF35-related protein Urp contacts the 3' splice site to promote U12-type intron splicing and the second step of U2-type intron splicing. Shen H, et al. Genes Dev, 2010 Nov 1. PMID 21041408, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables pre-mRNA 3'-splice site binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables pre-mRNA 3'-splice site binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in mRNA splicing, via spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mRNA splicing, via spliceosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in spliceosomal complex assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of U12-type spliceosomal complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of U2AF complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of spliceosomal complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit-related protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001427289.1 → NP_001414218.1  U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit-related protein 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000021
      UniProtKB/TrEMBL
      D3ZHQ8
      Related
      ENSRNOP00000049816.5, ENSRNOT00000045300.7

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086039.1 Reference GRCr8

      Range
      34179279..34201989
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006256887.5 → XP_006256949.1  U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit-related protein 2 isoform X1

      See identical proteins and their annotated locations for XP_006256949.1

      UniProtKB/TrEMBL
      D3ZHQ8
      Conserved Domains (3) summary
      smart00356
      Location:306 → 331
      ZnF_C3H1; zinc finger
      cd12540
      Location:199 → 303
      RRM_U2AFBPL; RNA recognition motif in U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit-related protein 1 (U2AFBPL) and similar proteins
      pfam00642
      Location:167 → 191
      zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)
    Nucleotide Protein Strain
    Heading Accession and Version

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