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    Rhno1 RAD9-HUS1-RAD1 interacting nuclear orphan 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 297627, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Rhno1provided by RGD
    Official Full Name
    RAD9-HUS1-RAD1 interacting nuclear orphan 1provided by RGD
    Primary source
    RGD:1359404
    See related
    EnsemblRapid:ENSRNOG00000028517 AllianceGenome:RGD:1359404
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable chromatin-protein adaptor activity. Predicted to be involved in several processes, including DNA repair; cellular response to radiation; and regulation of cell cycle process. Predicted to be active in chromatin; nucleus; and site of double-strand break. Orthologous to human RHNO1 (RAD9-HUS1-RAD1 interacting nuclear orphan 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Testes (RPKM 82.2), Thymus (RPKM 80.3) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Rhno1 in Genome Data Viewer
    Location:
    4q42
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (163320141..163325527, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (161634047..161639437, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (161679674..161685060, complement)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene influenza virus NS1A binding protein, pseudogene 1 Neighboring gene TUB like protein 3 Neighboring gene forkhead box M1 Neighboring gene testis expressed 52 Neighboring gene nuclear receptor interacting protein 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Involvement of C12orf32 overexpression in breast carcinogenesis. Kim JW, et al. Int J Oncol, 2010 Oct. PMID 20811708
    2. A DNA damage response screen identifies RHINO, a 9-1-1 and TopBP1 interacting protein required for ATR signaling. Cotta-Ramusino C, et al. Science, 2011 Jun 10. PMID 21659603, Free PMC Article
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC94282

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables chromatin-protein adaptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables chromatin-protein adaptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA damage checkpoint signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in DNA damage checkpoint signaling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular response to UV ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular response to ionizing radiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in chromatin organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in double-strand break repair via alternative nonhomologous end joining ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in double-strand break repair via alternative nonhomologous end joining ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of G0 to G1 transition ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein localization to site of double-strand break ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein localization to site of double-strand break ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in recombinational repair IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in recombinational repair ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in chromatin ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in chromosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in chromosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in site of double-strand break ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in site of double-strand break ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    RAD9, HUS1, RAD1-interacting nuclear orphan protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001401973.1 → NP_001388902.1  RAD9, HUS1, RAD1-interacting nuclear orphan protein 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000004
      UniProtKB/Swiss-Prot
      Q6AY26
      UniProtKB/TrEMBL
      A0A8I6ACD6
      Related
      ENSRNOP00000036772.3, ENSRNOT00000039086.6

    2. NM_001401974.1 → NP_001388903.1  RAD9, HUS1, RAD1-interacting nuclear orphan protein 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000004
      UniProtKB/Swiss-Prot
      Q6AY26
      UniProtKB/TrEMBL
      A0A8I6ACD6

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      163320141..163325527 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063285914.1 → XP_063141984.1  RAD9, HUS1, RAD1-interacting nuclear orphan protein 1 isoform X1

      UniProtKB/Swiss-Prot
      Q6AY26
      UniProtKB/TrEMBL
      A0A8I6ACD6

    2. XM_063285911.1 → XP_063141981.1  RAD9, HUS1, RAD1-interacting nuclear orphan protein 1 isoform X1

      UniProtKB/Swiss-Prot
      Q6AY26
      UniProtKB/TrEMBL
      A0A8I6ACD6

    3. XM_063285912.1 → XP_063141982.1  RAD9, HUS1, RAD1-interacting nuclear orphan protein 1 isoform X1

      UniProtKB/Swiss-Prot
      Q6AY26
      UniProtKB/TrEMBL
      A0A8I6ACD6

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001007649.1: Suppressed sequence

      Description
      NM_001007649.1: This RefSeq was permanently suppressed because it is now thought that this gene does not encode a protein.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6AY26.1 GenPept UniProtKB/Swiss-Prot:Q6AY26

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials