Cep57 centrosomal protein 57 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Cep57provided by RGD
Official Full Name: centrosomal protein 57provided by RGD
Primary source: RGD:1309884
See related: EnsemblRapid:ENSRNOG00000006792 AllianceGenome:RGD:1309884
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1309884; 3110002l15rik
Summary: Predicted to enable fibroblast growth factor binding activity; microtubule binding activity; and protein homodimerization activity. Predicted to be involved in fibroblast growth factor receptor signaling pathway; protein homooligomerization; and spermatid development. Predicted to be located in several cellular components, including Golgi apparatus; cytosol; and microtubule cytoskeleton. Predicted to be active in centrosome. Human ortholog(s) of this gene implicated in mosaic variegated aneuploidy syndrome 2. Orthologous to human CEP57 (centrosomal protein 57). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Testes (RPKM 131.4), Thymus (RPKM 120.6) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 8q12

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	8	NC_086026.1 (18951179..18971205, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	8	NC_051343.1 (10669588..10689257, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	8	NC_005107.4 (12335430..12355425, complement)

Chromosome 8 - NC_086026.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables fibroblast growth factor binding	ISO Inferred from Sequence Orthology more info
enables gamma-tubulin binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables microtubule binding	IBA Inferred from Biological aspect of Ancestor more info
enables microtubule binding	IEA Inferred from Electronic Annotation more info
enables microtubule binding	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in fibroblast growth factor receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in protein homooligomerization	ISO Inferred from Sequence Orthology more info
involved_in spermatid development	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in centriolar satellite	IEA Inferred from Electronic Annotation more info
located_in centriolar satellite	ISO Inferred from Sequence Orthology more info
is_active_in centrosome	IBA Inferred from Biological aspect of Ancestor more info
located_in centrosome	IEA Inferred from Electronic Annotation more info
located_in centrosome	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in microtubule	IEA Inferred from Electronic Annotation more info
located_in microtubule	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: centrosomal protein of 57 kDa

Names: centrosomal protein 57kDa; translokin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001108124.3 → NP_001101594.2 centrosomal protein of 57 kDa

See identical proteins and their annotated locations for NP_001101594.2

Status: VALIDATED

Source sequence(s)

BC168198, BI291153, CB807650

UniProtKB/Swiss-Prot

B4F7A7

UniProtKB/TrEMBL

A0A8I6A259, A6JN77

Related

ENSRNOP00000009318.6, ENSRNOT00000009318.8

Conserved Domains (2) summary

pfam06657
Location:351 → 419

Cep57_MT_bd; Centrosome microtubule-binding domain of Cep57

pfam14073
Location:68 → 245

Cep57_CLD; Centrosome localization domain of Cep57

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086026.1 Reference GRCr8

Range

18951179..18971205 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006242524.5 → XP_006242586.1 centrosomal protein of 57 kDa isoform X1

See identical proteins and their annotated locations for XP_006242586.1

UniProtKB/TrEMBL

A0A8I6A259

Conserved Domains (2) summary

pfam06657
Location:324 → 393

Cep57_MT_bd; Centrosome microtubule-binding domain of Cep57

pfam14073
Location:41 → 218

Cep57_CLD; Centrosome localization domain of Cep57
XM_039081340.2 → XP_038937268.1 centrosomal protein of 57 kDa isoform X1

UniProtKB/TrEMBL

A0A8I6A259

Conserved Domains (2) summary

pfam06657
Location:324 → 393

Cep57_MT_bd; Centrosome microtubule-binding domain of Cep57

pfam14073
Location:41 → 218

Cep57_CLD; Centrosome localization domain of Cep57
XM_006242523.5 → XP_006242585.1 centrosomal protein of 57 kDa isoform X1

See identical proteins and their annotated locations for XP_006242585.1

UniProtKB/TrEMBL

A0A8I6A259

Conserved Domains (2) summary

pfam06657
Location:324 → 393

Cep57_MT_bd; Centrosome microtubule-binding domain of Cep57

pfam14073
Location:41 → 218

Cep57_CLD; Centrosome localization domain of Cep57
XM_063265328.1 → XP_063121398.1 centrosomal protein of 57 kDa isoform X1

UniProtKB/TrEMBL

A0A8I6A259

Related

ENSRNOP00000085671.1, ENSRNOT00000111369.2
XM_039081342.2 → XP_038937270.1 centrosomal protein of 57 kDa isoform X2

Conserved Domains (2) summary

pfam06657
Location:202 → 271

Cep57_MT_bd; Centrosome microtubule-binding domain of Cep57

pfam14073
Location:5 → 96

Cep57_CLD; Centrosome localization domain of Cep57
XM_039081348.2 → XP_038937276.1 centrosomal protein of 57 kDa isoform X5

Conserved Domains (2) summary

pfam06657
Location:142 → 211

Cep57_MT_bd; Centrosome microtubule-binding domain of Cep57

pfam14073
Location:1 → 36

Cep57_CLD; Centrosome localization domain of Cep57
XM_039081341.2 → XP_038937269.1 centrosomal protein of 57 kDa isoform X3

UniProtKB/TrEMBL

A6JN79

Conserved Domains (2) summary

pfam06657
Location:202 → 271

Cep57_MT_bd; Centrosome microtubule-binding domain of Cep57

pfam14073
Location:1 → 96

Cep57_CLD; Centrosome localization domain of Cep57
XM_039081343.2 → XP_038937271.1 centrosomal protein of 57 kDa isoform X4

Conserved Domains (2) summary

pfam06657
Location:150 → 219

Cep57_MT_bd; Centrosome microtubule-binding domain of Cep57

pfam14073
Location:1 → 44

Cep57_CLD; Centrosome localization domain of Cep57